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Adenoviral p53 Gene Therapy Strategies in Nonsmall-Cell Lung Cancer

  • Stephen G. Swisher
  • Jack A. Roth
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Lung cancer is a worldwide problem. In the United States, less than 15% of people presenting with lung cancer survive 5 yr. Early-stage lung cancer (Stage I and II) is curable with surgery. Unfortunately, the majority of patients present with locoregionally advanced (Stage III) or metastatic (Stage IV) lung cancer, which is seldom curable with surgery alone. Multimodality approaches with conventional therapies have been developed combining surgery, chemotherapy, and radiation therapy to improve survival. Unfortunately, despite these strategies, the 3-yr survival rates for patients with Stage III disease are still only 20% dropping to less than 5% for Stage IV patients. Additionally, many of the lung cancer patients now in treatment have failed currently available multimodality strategies, often because their tumors have proven remarkably resistant to the effects of radiation or chemotherapy. Although some progress has been made in combining conventional therapies, the increased toxicity is often unacceptable and median survival of nonsmall-cell lung cancer (NSCLC) patients has not markedly improved (1). The identification of novel, less toxic cancer therapy strategies is therefore critical to improve on current treatment strategies, and it is becoming increasingly clear that rational development of these new therapies will depend on our understanding of the molecular biology of tumors.

Keywords

Advanced NSCLC Human Lung Cancer Cell Compute Tomography Guidance Gene Therapy Strategy Gene Therapy Trial 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Stephen G. Swisher
  • Jack A. Roth

There are no affiliations available

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