Receptor Tyrosine Kinases as Therapeutic Targets in Solid Tumors

  • Stacy L. Moulder
  • Carlos L. Arteaga
Part of the Cancer Drug Discovery and Development book series (CDD&D)


The introduction of nonspecific cytotoxic chemotherapeutic agents has provided palliation of symptoms, increased survival, and sometimes cure in patients with metastatic cancer. Unfortunately, patients with metastatic disease that are most likely to receive significant survival benefits from chemotherapy include those with less common malignancies, such as testis cancer and lymphoid neoplasms. In other more common malignancies, such as metastatic colon cancer or nonsmall-cell lung cancer (NSCLC), cytotoxic chemotherapy serves to palliate symptoms and has little or no role in prolonging life. Because of the nonspecific action of most current cytotoxic anticancer drugs, side effects such as bone marrow suppression, renal toxicity, and myocardial toxicity can often limit a patient’ s eligibility for and tolerance to therapy.


Vascular Endothelial Growth Factor Epidermal Growth Factor Receptor Tyrosine Kinase Clin Oncol Metastatic Breast Cancer 
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© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Stacy L. Moulder
  • Carlos L. Arteaga

There are no affiliations available

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