The Role of Combined Chemotherapy and Radiation Therapy in the Treatment of Gynecologic Malignancies
In women with lower-genital-tract carcinomas—cervical, vaginal, and vulvar carcinomas—hematogenous metastases are rarely present at diagnosis, and thus disease can frequently be controlled with local treatment. Small tumors can usually be treated with surgery alone, but cancers that penetrate deeply, particularly those that involve adjacent tissues or regional lymph nodes, require radiation therapy. Although radiation therapy controls pelvic disease in many cases, local and regional recurrence frequently contributes to the death of patients who are not cured with local treatment. To reduce these recurrences and improve cure rates, investigators have sought effective ways of combining chemotherapy with radiation therapy.
KeywordsCervical Cancer Radiat Oncol Biol Phys Radiation Therapy Oncology Group Vulvar Cancer Gynecologic Oncology Group
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