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Cerebral Cortex—Anesthetic Action on the Electroencephalogram

Cellular and Synaptic Mechanisms and Clinical Monitoring

  • Chapter
Neural Mechanisms of Anesthesia

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

No one will argue with the statement that general anesthetics exert their action by affecting normal brain function. This then begs the question: what exactly is “normal brain function” and how is it affected by general anesthetics? At a reductionist level one may attempt to understand anesthetic effects on the brain by examining anesthetic actions on individual neurons (e.g., spike train frequency), synapses (e.g., amplitude and time course of synaptic currents), and/or ion channels (e.g., activation and inactivation kinetics). While this mode of study will no doubt yield a plethora of useful information (as is documented in Neural Mechanisms of Anesthesia), it is likely to tell only part of the story of how general anesthetics evoke their myriad of consciousness altering effects. A more complete understanding of anesthetic effects on the brain will necessitate hypotheses that explain how anesthetics disrupt synchronous and coordinate neuronal network activities that are thought to give rise to emergent brain properties such as consciousness, learning and memory, and the perception of pain.

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Authors
  1. Heath Lukatch
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  2. Scott Greenwald
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Editors and Affiliations

  1. Department of Anesthesiology, University of California at Davis School of Medicine, Davis, CA, USA

    Joseph F. Antognini MD

  2. Department of Neurobiology, Physiology and Behavior, University of California at Davis School of Medicine, Davis, CA, USA

    Earl Carstens PhD

  3. Department of Anesthesia and Critical Care, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

    Douglas E. Raines MD

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Lukatch, H., Greenwald, S. (2003). Cerebral Cortex—Anesthetic Action on the Electroencephalogram. In: Antognini, J.F., Carstens, E., Raines, D.E. (eds) Neural Mechanisms of Anesthesia. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-322-4_6

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  • DOI: https://doi.org/10.1007/978-1-59259-322-4_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-294-0

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