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Actions of General Anesthetic on Voltage-Gated Ion Channels

  • Chapter
Neural Mechanisms of Anesthesia

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Neuronal signaling depends on rapid changes in electrical fields across cell membranes mediated by ion channels. Three important properties of these transmembrane proteins facilitate the rapid changes in membrane potential: passive conduction of ions, ion selectivity, and open and closing (gating) in response to electrical, mechanical, or chemical signals.

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Authors
  1. Norbert Topf
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  2. Esperanza Recio-Pinto
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  3. Thomas J. J. Blanck
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  4. Hugh C. Hemmings Jr.
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Editors and Affiliations

  1. Department of Anesthesiology, University of California at Davis School of Medicine, Davis, CA, USA

    Joseph F. Antognini MD

  2. Department of Neurobiology, Physiology and Behavior, University of California at Davis School of Medicine, Davis, CA, USA

    Earl Carstens PhD

  3. Department of Anesthesia and Critical Care, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

    Douglas E. Raines MD

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Topf, N., Recio-Pinto, E., Blanck, T.J.J., Hemmings, H.C. (2003). Actions of General Anesthetic on Voltage-Gated Ion Channels. In: Antognini, J.F., Carstens, E., Raines, D.E. (eds) Neural Mechanisms of Anesthesia. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-322-4_18

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