Abstract
The immune system of invertebrates has been the object of intense scrutiny ever since Elie Metchnikoff first discovered phagocytosis in starfish embryos in 1884 (1). Not surprisingly, the cellular arm of the insect innate immune response was the first to be investigated at the turn of the 20th century. Glaser and Paillot, followed later on by Metalnikow, uncovered the existence of a humoral arm of the insect host defense (2–5). However, the nature of the antimicrobial activity found in the hemolymph of immunized insects was not determined until the early 1980s, when Hans Boman’s pioneering work led to the purification in the moth Hyalophora cecropia of small cationic peptides that were called cecropins (6). Hundreds of peptides with antimicrobial activities were subsequently identified and characterized from insects of most orders (reviewed in ref. 7). Understanding the mechanisms responsible for their production is a major goal of recent research in innate immunity. For the last 10 years, Drosophila has been one major model system successfully used to dissect the molecular cascades controlling innate immunity in invertebrates. We describe here the current knowledge of the humoral and cellular arms of Drosophila immunity and highlight the similarities and disparities with the mammalian immune system.
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Royet, J., Meister, M., Ferrandon, D. (2003). Humoral and Cellular Responses in Drosophila Innate Immunity. In: Ezekowitz, R.A.B., Hoffmann, J.A. (eds) Innate Immunity. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-320-0_8
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DOI: https://doi.org/10.1007/978-1-59259-320-0_8
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