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The Role of Chemokines in Linking Innate and Adaptive Immunity

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Innate Immunity

Part of the book series: Infectious Disease ((ID))

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Abstract

Of the myriad of immune defense systems that exist in nature, the mammalian defense system is clearly the most sophisticated and successful. This immune sophistication arises from the fact that immune events in mammals involve a progression of detailed events leading to exquisite specificity toward a bacterial, viral, or fungal byproduct, or a nonself protein. On its simplest level, the immune response in mammals is divided into two major components: the nonspecific innate and the adaptive or acquired immune systems (1). When examined phylogenetically, the innate immune system appears to be more ancient than its acquired counterpart, and, historically, it was thought that the innate response was nonselectively directed toward microorganisms. However, the distinctions between the innate and acquired immune responses are now widely viewed as somewhat artificial, as it has been shown that both arms of the immune response share several common features including amazing degrees of specificity for pathogens and foreign antigens (2). Indeed, there is increasing evidence that the induction of different types of effector adaptive responses is directed by the innate immune system after its highly selective recognition of particular groups of pathogens through pattern recognition molecules (i.e., the Toll-like receptor family) and the elaboration of soluble protein signals that activate the relevant lymphoid cell population.

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Authors
  1. Cory M. Hogaboam
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  2. Steven L. Kunkel
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Editors and Affiliations

  1. Laboratory of Developmental Immunology, Massachusetts General Hospital, Boston, MA, USA

    R. Alan B. Ezekowitz MB ChB, DPhil, FAAP

  2. Department of Pediatrics, Harvard Medical School, Boston, MA, USA

    R. Alan B. Ezekowitz MB ChB, DPhil, FAAP

  3. Institute of Molecular and Cellular Biology, CNRS, Strasbourg, France

    Jules A. Hoffmann PhD

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Hogaboam, C.M., Kunkel, S.L. (2003). The Role of Chemokines in Linking Innate and Adaptive Immunity. In: Ezekowitz, R.A.B., Hoffmann, J.A. (eds) Innate Immunity. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-320-0_15

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  • DOI: https://doi.org/10.1007/978-1-59259-320-0_15

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