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Immunology of the Gastrointestinal Tract

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Colonic Diseases

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Abstract

The gastrointestinal system is essentially a long muscular tube, the functional surface of which is a thin, mucus-coated layer approx 1 mm thick, that is joined at both ends with the external integument and, thus, is a contact surface with the external environment (1). The surface area of the adult human intestine is estimated to be approx 300 M2 (2). This surface is constantly exposed to antigens, which, proximally, is mostly of dietary origin and, distally, tends to be bacterial products derived from colonic flora. Providing a protective barrier at this external surface is complicated by the need to selectively absorb nutrients. To prevent the colonization and/or invasion of the intestinal mucosa by foreign organisms, the intestine makes use of a number of innate and adaptive defense factors. This chapter provides a broad overview of immune responses in the intestine.

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Authors
  1. Jonathan R. Fulton
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  2. Cynthia A. Cunningham
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  3. Christopher F. Cuff
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Editors and Affiliations

  1. Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA

    Timothy R. Koch MD

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© 2003 Humana Press Inc., Totowa, NJ

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Fulton, J.R., Cunningham, C.A., Cuff, C.F. (2003). Immunology of the Gastrointestinal Tract. In: Koch, T.R. (eds) Colonic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-314-9_8

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  • DOI: https://doi.org/10.1007/978-1-59259-314-9_8

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9740-3

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