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Mucin and Goblet Cell Function

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Colonic Diseases

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Abstract

The intestine and colon are coated by a protective mucous gel. The mucous gel consists of a variety of large mucin glycoproteins, trefoil factors (TFF), defensins, secreted immunoglobulins (Ig), electrolytes, sloughed epithelial cells, phospholipids, commensal bacteria, and other components. These factors form a dynamic barrier that protects epithelial surfaces from toxins, harmful bacteria, parasites, and digestive chemicals. Mucous gel components are largely derived from the secretory products of goblet cells. The protective functions of goblet cell products make them an integral part of the innate immune response of the gut. This review will focus on recent insights into the function of intestinal goblet cells and their secretory products that contribute to the protective mucous layer.

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Authors
  1. Samuel B. Ho
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  2. Laurie L. Shekels
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Editors and Affiliations

  1. Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA

    Timothy R. Koch MD

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© 2003 Humana Press Inc., Totowa, NJ

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Ho, S.B., Shekels, L.L. (2003). Mucin and Goblet Cell Function. In: Koch, T.R. (eds) Colonic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-314-9_4

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  • DOI: https://doi.org/10.1007/978-1-59259-314-9_4

  • Publisher Name: Humana Press, Totowa, NJ

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