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Absorption—Secretion and Epithelial Cell Function

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Colonic Diseases

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Abstract

Under normal physiological conditions, the mammalian colon absorbs Na+, Cl−, and water and secretes K+ and HCO −3 . In diarrheal disorders, disturbances in ion transport result in excessive secretion of electrolytes and water. In recent years, a number of reviews have addressed the mechanisms of ion transport in mammalian intestine. Also, the recent molecular cloning of several electrolyte transporters has dramatically advanced our knowledge of molecular mechanisms of the electrolyte transport in the mammalian intestine. This chapter reviews the role of various absorptive and secretory processes in colonic physiology with special emphasis on the human colon. Current advances in molecular mechanisms of absorption of Na+, Cl−, short chain fatty acids (SCFA), Hp, sulfate, oxalate, and bacterially synthesized water soluble vitamins, as well as mechanisms of secretion of Cl−, HCO −3 and K+ are discussed. Lastly, the regulation of these transporters under physiological and pathophysiological conditions and the importance of these transport mechanisms to the colonocyte integrity and function is evaluated.

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Authors
  1. Pradeep K. Dudeja
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  2. Ravinder Gill
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  3. K. Ramaswamy
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Editors and Affiliations

  1. Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA

    Timothy R. Koch MD

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Dudeja, P.K., Gill, R., Ramaswamy, K. (2003). Absorption—Secretion and Epithelial Cell Function. In: Koch, T.R. (eds) Colonic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-314-9_1

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