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Oncogenes as Regulators of Cell Survival

The Role of Oncogenes and Tumor Suppressor Genes in the Induction of Resistance to Anoikis and Hypoxia

  • Chapter
Oncogene-Directed Therapies

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

During the past few years, it has become obvious that resistance to programmed cell death, or apoptosis, plays a major role in the process of malignant transformation and subsequent tumor progression. Molecular mechanisms of such resistance induced by the activation of various proto-oncogenes and the loss of activity of tumor suppressor genes have begun to emerge. In parallel, our knowledge of the principles governing the functioning of the intrinsic cell death machinery has expanded considerably.

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Authors
  1. Kirill Rosen PhD
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  2. Jorge Filmus PhD
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Editors and Affiliations

  1. Henderson Research Centre, Department of Medicine, McMaster University, Hamilton, Ontario, Canada

    Janusz Rak MD, PhD

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Rosen, K., Filmus, J. (2003). Oncogenes as Regulators of Cell Survival. In: Rak, J. (eds) Oncogene-Directed Therapies. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-313-2_9

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