Abstract
Deep brain stimulation (DBS) has become a widely performed procedure for the treatment of advanced medication-refractory movement disorders, including Parkinson’ s disease (PD), dystonia, and various forms of tremor. DBS has been applied to the ventral intermedius (Vim) nucleus of the thalamus, globus pallidus internus (GPi), and subthalamic nucleus (STN). The exact mechanism of action of DBS is unknown, but is consistent with high-frequency stimulation blocking the activity of the target nucleus by direct or indirect means.
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References
Schuurman, P. R., Bosch, D. A., Bossuyt, P. M., Bonsel, G. J., van Someren, E. J., de Bie, R. M., et al. (2000) A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N. Engl. J. Med. 342, 461–468.
Koller, W., Pahwa, R., Busenbark, K., et al. (1997) High frequency unilateral thalamic stimulation in the treatment of essential and parkinsonaim tremor. Ann. Neurol. 42, 292–299.
Limousin, P., Speelman, J. D., Gielen, F., Janssens, M. and study collaborators. (1999) Multicentre European study of thalamic stimulation in parkinsonsian and essential tremor. J. Neurol. Neurosurg. Psychiatry 66, 289–296.
DBS Study Group. (2001) The Deep-Brain stimulation for Parkinson’s Disease. Deep-Brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson’s Disease. N. Engl. J. Med. 345, 956–963.
Limousin, P., Krack, P., Pollak, P., Benazzouz, A., Ardouin, C., Hoffmann, D., and Benabid, A. L. (1998) Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N. Engl. J. Med. 339, 1105–1111.
Kumar, R., Lozano, A. M., Kim, Y. J., Hutchison, W. D., Sime, E., Halket, E., and Lang, A. E. (1998) Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson’s disease. Neurology 51, 850–855.
Krack, P., Pollak, P., Limousin, P., Hoffmann, D., Xie, J., Benazzouz, A., and Benabid, A. L. (1998) Subthalamic nucleus or internal pallidal stimulation in young onset Parkinson’s disease. Brain 121, 451–457.
Volkmann, J., Allert, N., Voges, J., Weiss, P. H., Freund, H. J., and Sturm, V. (2001) Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD. Neurology 56, 548–551.
Saint-Cyr, J. A., Trepanier, L. L., Kumar, R., Lozano, A. M., and Lang, A. E. (2000) Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson’s disease. Brain 123, 2091–2108.
Coubes, P., Roubertie, A., Vayssiere, N., Hemm, S., and Echenne, B. (2000) Treatment of DYT1-generalised dystonia by stimulation of the internal globus pallidus. Lancet 355, 2220–2221.
Vercueil, L., Fraix, V., Moro, E., Caputo, E., et al. (2001) Deep brain stimulation for severe dystonia: 17 observations. J. Neurol. 248, 695–700.
Kumar, R., Dagher, A., Hutchison, W. D., Lang, A. E., and Lozano, A. M. (1999) Globus pallidus deep brain stimulation for generalized dystonia: clinical and PET investigation. Neurology 53, 871–874.
Krauss, J. K., Pohle, T., Weber, S., Ozdoba, C., and Burgunder, J. M. (1999) Bilateral stimulation of globus pallidus internus for treatment of cervical dystonia. Lancet 354, 837–838.
Parkin, S., Aziz, T., Gregory, R., and Bain, P. (2001) Bilateral internal globus pallidus stimulation for the treatment of spasmodic torticollis. Mov. Disord. 16, 489–493.
Roubertie, A., Cif, L., Vayssiere, N., et al. (2000) Symptomatic generalized dystonia: neurosurgical treatment by continuous bilateral stimulation of the internal globus pallidus in eight patients. Mov. Disord. 15(Suppl. 3), 156.
Loher, T. J., Hasdemir, M. G., Burgunder, J.-M., and Krauss, J. K. (2000) Long-term follow-up study of chronic blobus pallidus internus stimulation for post-traumatic hemidystonia. Case Report. J. Neurosurg. 92, 457–460.
Benabid, A. L., Pollak, P., Gao, D. M., Hoffmann, D., Limousin, P., Gay, E., et al. (1996) Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J. Neurosurg. 84, 203–214.
Caparros-Lefebvre, D., Blond, S., Feltin, M. P., Pollak, P., and Benabid, A. L. (1999) Improvement of levodopa induced dyskinesias by thalamic deep brain stimulation is related to slight variation in electrode placement: possible involvement of the centre median and parafascicularis complex. J. Neurol. Neurosurg. Psychiatry 67, 308–314.
Narabayashi, H., Yokoshi, F., and Nakajima, Y. (1984) Levodopa-induced dyskinesia and thalamotomy. J. Neurol. Neurosurg. Psychiatry 47, 831–839.
Kumar, R., Lang, A. E., Rodriguez, M. C., Lozano, A. M., Limousin, P., Pollak, P., et al. (2000) Deep brain stimulation of the globus pallidus pars interna in advanced Parkinson’s disease. Neurology 55(Suppl. 6), 834–839.
Ghika, J., Ghika-Schmid, F., Fankhauser, H., Assal, G., Vingerhoets, F., Albanese, A., et al. (1999) Bilateral contemporaneous posteroventral pallidotomy for the treatment of Parkinson’s disease: neuropsychological and neurological side effects. Report of four cases and review of the literature. J. Neurosurg. 91, 313–321.
Galvez-Jimenez, N., Lozano, A., Tasker, R., Duff, J., Hutchison, W., and Lang, A. E. (1998) Pallidal stimulation in Parkinson’s disease patients with a prior unilateral pallidotomy, Can. J. Neurol. Sci. 25, 300–305.
Bejjani, B., Damier, P., Arnulf, I., Bonnet, A. M., Vidailhet, M., Dormont, D., et al. (1997) Pallidal stimulation for Parkinson’s disease. Two targets? Neurology 49, 1564–1569.
Krack, P., Pollak, P., Limousin, P., Hoffmann, D., Benazzouz, A., Le Bas, J. F., et al. (1998) Opposite motor effects of pallidal stimulation in Parkinson’s disease. Ann. Neurol. 43, 180–192.
Yelnik, J., Damier, P., Bejjani, B. P., et al. (2000) Functional mapping of the human globus pallidus: contrasting effect of stimulation in the internal and external pallidum in Parkinson’s disease. Neuroscience 101, 77–87.
Vitek, J. L., Evatt, M., Zhang, J.-Y., et al. (1999) Pallidotomy and deep brain stimulation as a treatment for dystonia. Neurology 52(Suppl. 2), A294.
Ashby, P. (2000) What does stimulation in the brain actually do? Progr. Neurolog. Surg. 15, 236–245.
Ranck, J. B. (1975) Which elements are excited in electrical stimulation of mammalian central nervous system? A review. Brain Res. 98, 417–440.
Pollak, P. (2000) Deep Brain Stimulation. Annual Course of the American Academy of Neurology. Innovative surgical treatment of movement disorders 3AC.0006. San Diego.
Defer, G. L., Widner, H., Marie, R. M., Remy, P., and Levivier, M. (1999) Core assessment program for surgical interventional therapies in Parkinson’s disease (CAPSIT-PD). Mov. Disord. 14, 572–584.
Kumar, R., Lang, A. E., Sime, E., and Lozano, A. M. (1999) Late failure of thalamic deep brain stimulation in Parkinson’s disease and essential tremor. Neurology 52(Suppl. 2), A457–A457.
Koller, W. C., Lyons, K. E., Wilkinson, S. B., Troster, A. I., and Pahwa, R. (2001) Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor. Mov. Disord. 16, 464–468.
Oh, M. Y., Hodaie, M., Kim, S. H., Alkhani, A., Lang, A. E., and Lozano, A. M. (2001) Deep brain stimulator electrodes used for lesioning: proof of principle. Neurosurgery 49, 363–367.
Kumar, R. and McVicker, J. M. (2000) Radiofrequency lesioning through an implanted deep brain stimulating electrode: treatment of tolerance to thalamic stimulation in essential tremor. Mov. Disord. 15(Suppl. 3), 69.
Hariz, M. I., Shamsgovara, P., Johansson, F., Hariz, G. M., and Fodstad, H. (1999) Tolerance and tremor rebound following long-term thalamic stimulation for parkinsonian and essential tremor. Sterotact. Funct. Neurosurg. 72, 208–218.
Limousin, P., Pollak, P., Hoffmann, D., Benazzouz, A., Perret, J., and Benabid, A. L. (1996) Abnormal involuntary movements induced by subthalamic nucleus stimulation. Mov. Disord. 11, 231–235.
Volkmann, J., Fogel, W., and Krack, P. (2000) Postoperative neurological management-stimulation of the subthalamic nucleus. Akt. Neurol. 27(Suppl. 1), 823–839.
Fraix, V., Pollak, P., Van Blercom, N., Xie, J., Krack, P., Koudsie, A., and Benabid, A. L. (2000) Effect of subthalamic nucleus stimulation on levodopa-induced dyskinesia in Parkinson’s disease. Neurology 55, 1921–1923.
Kumar, R., Kedia, S., and McVicker, J. H. (2001) Chronic electrical stimulation of the zona incerta and fields of Forel in Parkinson’s disease: implications for the mechanism of deep brain stimulation. Mov. Disord. 16, 991.
Kumar, R. and Kramer, R. E. (2001) Emergence of restless legs syndrome (RLS) during subthalamic nucleus deep brain stimulation (STN DBS) for Parkinson’s disease (PD). Parkinsonism Rel. Disord. 7, S80.
Rye, D. B. and DeLong, M. R. (1999) Amelioration of sensory limb discomfort of restless legs syndrome by pallidotomy. Ann. Neurol. 46, 800–801.
Bejjani, B. P., Damier, P., Arnulf, I., Thivard, L., Bonnet, A. M., Dormont, D., et al. (1999) Transient acute depression induced by high-frequency deep-brain stimulation. N. Engl. J. Med. 340, 1476–1480.
Ghika, J., Vingerhoets, F., Albanese, A., and Villemure, J. G. (1999) Bipolar swings in mood in patient with bilaterak subthalamic nucleus deeo brain stimulation (DBS) free of antiparkinson medication [abstract]. Parkinsonism Rel. Disord. 5(Suppl. 1), 104.
Kumar, R., Krack, P., and Pollak, P. (1999) Transient acute depression-induced by high-frequency deep-brain stimulation [letter]. N. Engl. J. Med. 341, 1003–1004.
Krack, P., Kumar, R., Ardouin, C., Limousin-Dowsey, P., McVicker, J. H., Benabid, A.-L., and Pollak, P. (2001) Mirthful laughter induced by subthalamic nucleus stimulation. Mov. Disord. 16, 867–875.
Schaltenbrand, G. and Wahren, W. (1977) Atlas for Stereotaxy of the Human Brain, 2nd ed. Thieme, Stuttgart.
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Kumar, R. (2003). Methods of Programming and Patient Management with Deep Brain Stimulation. In: Tarsy, D., Vitek, J.L., Lozano, A.M. (eds) Surgical Treatment of Parkinson’s Disease and Other Movement Disorders. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-312-5_14
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DOI: https://doi.org/10.1007/978-1-59259-312-5_14
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