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Subthalamic Deep Brain Stimulation for Parkinson’s Disease

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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

An appreciation of the important modulatory role played by the subthalamic nucleus (STN) in regulating basal ganglia projections to the motor thalamus and brainstem, has led to interest in the STN as a target for the treatment of Parkinson’s disease (PD). In 1990, DeLong and colleagues first demonstrated the reversal of motor symptoms by lesioning the STN in monkeys with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced parkinsonism (1). Concern about the possibility of irreversible side effects from the generation of bilateral STN lesions, and experience with the safety (2) but limited efficacy of thalamic stimulation, prompted Benabid and colleagues to attempt STN deep brain stimulation (DBS) (3). Recent reports from several centers demonstrating the safety and efficacy of chronic high-frequency STN DBS have generated interest in the STN as a target of choice in the surgical treatment of PD.

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Authors
  1. Aviva Abosch
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  2. Anthony E. Lang
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  3. William D. Hutchison
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  4. Andres M. Lozano
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Editor information

Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Daniel Tarsy MD

  2. Emory University School of Medicine, Atlanta, GA, USA

    Jerrold L. Vitek MD, PhD

  3. Toronto Western Hospital, Toronto, ON, Canada

    Andres M. Lozano MD, PhD

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© 2003 Humana Press Inc., Totowa, NJ

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Abosch, A., Lang, A.E., Hutchison, W.D., Lozano, A.M. (2003). Subthalamic Deep Brain Stimulation for Parkinson’s Disease. In: Tarsy, D., Vitek, J.L., Lozano, A.M. (eds) Surgical Treatment of Parkinson’s Disease and Other Movement Disorders. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-312-5_13

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  • DOI: https://doi.org/10.1007/978-1-59259-312-5_13

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9736-6

  • Online ISBN: 978-1-59259-312-5

  • eBook Packages: Springer Book Archive

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