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Genetics of Inflammatory Bowel Disease

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Inflammatory Bowel Disease

Part of the book series: Clinical Gastroenterology ((CG))

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Abstract

The inflammatory bowel diseases (IBD) (Crohn’s disease [CD] and ulcerative colitis [UC]) are defined by chronic, intermittent inflammation of the intestines, resulting in abdominal pain, diarrhea, and rectal bleeding. These diseases have a peak incidence between 15–30 yr of age, and a combined prevalence of 200–300/100,000 in the United States, therefore representing a major cause of morbidity in young adults (1–3). The earliest steps in the pathogenesis of IBD are currently undefined. Development of significantly better medical therapies for IBD is dependent on developing a more specific understanding of the earliest stages of pathogenesis. Furthermore, reclassification of these disorders based on identification of molecular mechanisms of pathogenesis holds the promise of tailoring medical therapies to individual patients.

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Authors
  1. Judy Cho MD
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Editors and Affiliations

  1. Section of Gastroenterology, Department of Medicine, The University of Chicago Medical Center, Chicago, IL, USA

    Russell D. Cohen MD

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© 2003 Springer Science+Business Media New York

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Cho, J. (2003). Genetics of Inflammatory Bowel Disease. In: Cohen, R.D. (eds) Inflammatory Bowel Disease. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-311-8_4

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  • DOI: https://doi.org/10.1007/978-1-59259-311-8_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5465-0

  • Online ISBN: 978-1-59259-311-8

  • eBook Packages: Springer Book Archive

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