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Inflammatory Bowel Disease pp 17–31Cite as

Epidemiology of Inflammatory Bowel Disease

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Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Despite progress in understanding the immunoinflammatory response of the bowel and in therapeutic options in inflammatory bowel disease (IBD), there is still much to learn about disease etiology. Epidemiological studies examining differences in occurrence in different places and among different age groups, as well as at different times, can provide clues as to factors that influence the origin of these diseases. Also, new hypotheses regarding etiology can be generated. Defining disease epidemiology also leads to an appreciation of the magnitude of public health concern a disease poses. Epidemiological data about IBD have highlighted important public health concerns. For instance, the highest incidence of disease is seen in young adults. Thus, morbidity relating to disease and its therapy (i.e., surgery) will affect school and work productivity and possibly socialization and personal and family development. Furthermore, ulcerative colitis and Crohn’s colitis are associated with an increased risk for intestinal cancer and the associated increased mortality risk. Finally, the morbidity of these conditions is associated with considerable expenditure of health care resources and large indirect costs.

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References

  1. Bernstein CN, Shanahan F, Anton PA, Weinstein WM. Patchy involvement, including rectal sparing, occurs in ulcerative colitis (UC):A prospective study. Gastrointest Endosc 1995; 42: 232–237.

    Article  PubMed  CAS  Google Scholar 

  2. Lewin KJ, Riddell RH, Weinstein WM, eds. Idiopathic inflammatory bowel disease. In: Gastrointestinal Pathology and Its Clinical Implications. Igaku-Shoin, New York, 1992, 834–989.

    Google Scholar 

  3. Kyle J, Stark G. Fall in the incidence of Crohn’s disease. Gut 1980; 21: 340–343.

    Article  PubMed  CAS  Google Scholar 

  4. Devlin HB, Datta D, Dellipiani AW. The incidence and prevalence of inflammatory bowel disease in North Tees Health District. World J Surg 1980; 4: 183–193.

    Article  PubMed  CAS  Google Scholar 

  5. Shivananda S, Pena AS, Nap M, Weterman IT, Mayberry JF, Ruitenberg EJ, Hoedemaeker Ph J. Epidemiology of Crohn’s disease in Regio Leiden, The Netherlands. Gastroenterol 1987; 93: 966–974.

    CAS  Google Scholar 

  6. Rose JDR, Roberts GM, Williams G, Mayberry JF, Rhodes J. Cardiff Crohn’s disease jubilee:The incidence over 50 years. Gut 1988; 29: 346–351.

    Article  PubMed  CAS  Google Scholar 

  7. Kyle J. Crohn’s disease in the Northeastern and Northern Isles of Scotland:An epidemiological review. Gastroenterol 1992; 103: 392–399.

    CAS  Google Scholar 

  8. Logan RFA. Inflammatory bowel disease incidence:up, down or unchanged? Gut 1998; 42: 309–311.

    Article  PubMed  CAS  Google Scholar 

  9. Howarth GF, Robinson MHE, Jenkins D, Hardcastle JD, Logan RFA. High prevalence of undetected inflammatory bowel disease (IBD);Data from the Nottingham faecal occult blood (FOB) screening trial.

    Google Scholar 

  10. Moller C, Linden G. Ulcerative colitis in Finland:I. Cases treated at Central hospitals, 1956–1967. Dis Col Rect 1971; 14: 259–263.

    Article  CAS  Google Scholar 

  11. Evans JG, Acheson ED. An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area. Gut 1965; 6: 311–324.

    Article  PubMed  CAS  Google Scholar 

  12. Binder V, Both H, Hansen PK, Hendriksen C, Kreiner S, Torp-Pedersen K. Incidence and prevalence of ulcerative colitis and Crohn’s disease in the county of Copenhagen, 1962 to 1978. Gastroenterol 1982; 83: 563–568.

    CAS  Google Scholar 

  13. Sinclair TS, Brunt PW, Mowat NAG. Nonspecific proctocolitis in Northeastern Scotland:A community study. Gastroenterol 1983; 85: 1–11.

    CAS  Google Scholar 

  14. Morris T, Rhodes J. Incidence of ulcerative colitis in the Cardiff region 1968– 1977. Gut 1992; 33: 256–258.

    Article  PubMed  Google Scholar 

  15. Srivastava ED, Mayberry JF, Morris TJ, et al. Incidence of ulcerative colitis in Cardiff over 20 years: 1968–87. Gut 1992; 33: 256–258.

    Article  PubMed  CAS  Google Scholar 

  16. Berner J, Kiaer T. Ulcerative colitis and Crohn’s disease on the Faroe Islands 1964–83. A retrospective epidemiological survey. Scand J Gastroenterol 1986; 21: 188–192.

    Article  PubMed  CAS  Google Scholar 

  17. Shivananda S, Pena AS, Mayberry JF, Ruitenberg EJ, Hoedemaeker Ph J. Epidemiology of proctocolitis in the region of Leiden, The Netherlands. Scand J Gastroenterol 1987; 22: 993–1002.

    Article  PubMed  CAS  Google Scholar 

  18. Haug K, Schrumf E, Barstad S, et al. Epidemiology of ulcerative colitis in Western Norway. Scand J Gastroenterol 1988; 23: 517–522.

    Article  PubMed  CAS  Google Scholar 

  19. Ekbom A, Helmick C, Zack M, Adami H-O. The epidemiology of inflammatory bowel disease: a large population-based study in Sweden. Gastroenterol 1991; 100: 350–358.

    CAS  Google Scholar 

  20. Moum B, Vatn MH, Ekbom A, et al. Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990–1993. Scand J Gastroenterol 1996; 31: 362–366.

    Article  PubMed  CAS  Google Scholar 

  21. Gower-Rousseau C, Salomex JL, Dupas JL, et al. Incidence of inflammatory bowel disease in northern France (1988–1990). Gut 1994; 35: 1433–1438.

    Article  PubMed  CAS  Google Scholar 

  22. Gilat T, Ribak J, Benaroya Y, Zemishlany Z, Weissman I. Ulcerative colitis in the Jewish population of Tel-Aviv Jafo. I. Epidemiology. Gastroenterol 1974; 66: 335–342.

    CAS  Google Scholar 

  23. McDermott FT, Whelan G, St John JB, et al. Relative incidence of Crohn’s disease and ulcerative colitis in six Melbourne hospitals. Med J Aust 1987; 146: 525–529.

    PubMed  CAS  Google Scholar 

  24. Odes HS, Fraser D, Krawiec J. Ulcerative colitis in the Jewish population of Southern Israel 1961–1985:epidemiological and clinical study. Gut 1987; 28: 1630–1636.

    Article  PubMed  CAS  Google Scholar 

  25. Vucelic B, Korac B, Sentic M, et al. Ulcerative colitis in Zagreb Yugoslavia:incidence and prevalence 1980–1989. Int J Epidemiol 1991; 20: 1043–1047.

    Article  PubMed  CAS  Google Scholar 

  26. Probert CSJ, Jayanthi V, Mayberry JF. Inflammatory bowel disease in Indian migrants in Fiji. Digestion 1991; 50: 82–84.

    Article  PubMed  CAS  Google Scholar 

  27. Garland CF, Lilienfield AM, Mendeloff AI, Markowitz JA, Terrell KB, Garland FC. Incidence rates of ulcerative colitis and Crohn’s disease in fifteen areas of the United States. Gastroenterol 1981; 81: 1115–1124.

    CAS  Google Scholar 

  28. Stonnington CM, Phillips SF, Melton LJ III, Zinsmeister AR. Chronic ulcerative colitis:incidence and prevalence in a community. Gut 1987; 28: 402–409.

    Article  PubMed  CAS  Google Scholar 

  29. Loftus EV, Silverstein MD, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Ulcerative colitis in Olmsted County, Minnesota 1940–1993; incidence, prevalence and survival. Gut 2000; 46: 336–343.

    Article  PubMed  Google Scholar 

  30. Monk M, Mendeloff AI, Siegel CI, Lilienfeld A. An epidemiological study of ulcerative colitis and regional enteritis among adults in Baltimore. Gastroenterol 1967; 53: 198–210.

    Google Scholar 

  31. Sonnenberg A, McCarty DJ, Jacobsen SJ. Geographic variation of inflammatory bowel disease within the United States. Gastroenterol 1991; 100: 143–149.

    CAS  Google Scholar 

  32. Sonnenberg A, Wasserman IH. Epidemiology of inflammatory bowel disease among U.S. military veterans. Gastroenteroly 1991; 101: 122–130.

    CAS  Google Scholar 

  33. Pinchbeck BR, Kirdeikis J, Thomson ABR. Inflammatory bowel disease in Northern Alberta. An epidemiologic study. J Clin Gastroenterol 1988; 10: 505–515.

    Article  PubMed  CAS  Google Scholar 

  34. Pinchbeck BR, Kirdeikis J, Thomson ABR. Effect of religious affiliation and education status on the prevalence of inflammatory bowel disease in northern Alberta. Can J Gastroenterol 1988; 2 (Suppl A): 95A–100A.

    Google Scholar 

  35. Bernstein CN, Blanchard JF, Rawsthorne P, Wajda A. The epidemiology of Crohn’s disease and ulcerative colitis in a central Canadian province:a population-based study. Am J Epidemiol 1999; 149: 916–924.

    Article  PubMed  CAS  Google Scholar 

  36. Fahrländer H, Baerlocher CH. Clinical features and epidemiological data on Crohn’s disease in the Basle area. Scand J Gastroenterol 1971; 6: 657–662.

    Article  PubMed  Google Scholar 

  37. Norlen BJ, Krause U, Bergman L. An epidemiological study of Crohn’s disease. Scand J Gastroenterol 1970; 5: 385–390.

    PubMed  CAS  Google Scholar 

  38. Miller DS, Keighley AC, Langman MJS. Changing patterns in epidemiology of Crohn’s disease. Lancet 1974; II: 691–693.

    Article  Google Scholar 

  39. Brahme F, lindstrom C, Wenckert A. Crohn’s disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmö, Sweden. Gastroenterol 1975; 69: 342–351.

    CAS  Google Scholar 

  40. Hellers G. Crohn’s disease in Stockholm County 1955–1974. Acta Chir Scand 1979; 490: 1–84 (Suppl 1).

    Google Scholar 

  41. Mayberry J, Rhodes J, Hughes LE. Incidence of Crohn’s disease in Cardiff between 1934 and 1977. Gut 1979; 20: 602–608.

    Article  PubMed  CAS  Google Scholar 

  42. Lee FI, Costello FT. Crohn’s disease in Blackpool–incidence and prevalence 1968–1980. Gut 1985; 26: 274–278.

    Article  PubMed  CAS  Google Scholar 

  43. Jayanthi V, Probert CSJ, Pinder D, Wicks ACB, Mayberry JF. Epidemiology of Crohn’s disease in Indian migrants and the indigenous population in Leicestershire. Q J Med 1992; 82: 125–138.

    PubMed  CAS  Google Scholar 

  44. Munkholm P, Langholz E, Haagen Nielsen O, Kreiner S, Binder V. Incidence and prevalence of Crohn’s disease in the county of Copenhagen, 1962–87:A sixfold increase in incidence. Scand J Gastroenterol 1992; 27: 609–614.

    Article  PubMed  CAS  Google Scholar 

  45. Lapidus A, Bernell O, Hellers G, Persson P-G, Lofberg R. Incidence of Crohn’s disease in Stockholm County 1955–1989. Gut 97; 41: 480–486.

    Google Scholar 

  46. Calkins BM, Mendeloff AI. Epidemiology of inflammatory bowel disease. Epidem Rev 1986; 8: 60–91.

    CAS  Google Scholar 

  47. Rozen P, Zonis J, Yekutiel P, Gilat T. Crohn’s disease in the Jewish population of TelAviv-Yafo. Epidemiologic and clinical aspects. Gastroenterol1979; 76: 25–30.

    Google Scholar 

  48. Moum B, Vatn MH, Ekbom A, et al. Incidence of Crohn’s disease in four counties of southeastern Norway, 1990–1993. A prospective population-based study. Scand J Gastroenterol 1996; 31: 355–361.

    Article  PubMed  CAS  Google Scholar 

  49. Gollop JH, Phillips SF, Melton LJ III, Zinsmeister AR. Epidemiologic aspects of Crohn’s disease:a population based study in Olmstead County, Minnesota, 1943– 1982. Gut 1988; 29: 49–56.

    Article  PubMed  CAS  Google Scholar 

  50. Loftus EV, Silverstein MD, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Crohn’s disease in Olmsted County, Minnesota, 1940–1993; incidence, prevalence, and survival. Gastroenterol 1998; 114: 1161–1168.

    Article  Google Scholar 

  51. Loftus EV. The epidemiology of Crohn’s disease. Gastroenterology 1999; 116: 1502–1506 (reply).

    Google Scholar 

  52. Riley R. Crohn’s disease and ulcerative colitis-Morbidity and mortality:The Canadian experience. Can J Gastroenterol 1994; 8: 145–150.

    Google Scholar 

  53. Montgomery SM, Morris DL, Thompson NP, Subhani J, Pounder RE, Wakefield AJ. Prevalence of inflammatory bowel disease in British 26 year olds:national longitudinal birth cohort. Brit Med J 1998; 316: 1058–1060.

    Article  PubMed  CAS  Google Scholar 

  54. Whelan G. Epidemiology of inflammatory bowel disease. Med Clin N 1990; 74: 1–12.

    CAS  Google Scholar 

  55. Law NM, Lim CC, Chong R, Ng HS. Crohn’s disease in the Singapore Chinese population. J Clin Gastroenterol 1998; 26: 27–29.

    Article  PubMed  CAS  Google Scholar 

  56. Novis BH, Marks IN, Bank S, Louw JH. Incidence of Crohn’s disease at Groote Schuur Hospital during 1970–1974. S Afr Med J 1975; 49: 693–697.

    PubMed  CAS  Google Scholar 

  57. Segal I. Intestinal tuberculosis, Crohn’s disease and ulcerative colitis in an urban Black population. S Afr Med J 1984; 65: 37–44.

    PubMed  CAS  Google Scholar 

  58. Ruiz V. Crohn’s disease in Galacia, Spain. Scand J Gastroenterol 1989; 24 (suppl 170): 29–31.

    Article  Google Scholar 

  59. Shivinada S, Lennard-Jones J, Logan R, et al. Incidence of inflammatory bowel disease across Europe:is there a difference between north and south? Results of the European collaborative study on inflammatory bowel disease (EC-IBD). Gut 1996; 39: 690–697.

    Article  Google Scholar 

  60. Blanchard JF, Bernstein CN, Wajda A, Rawsthorne P. Small area variations socio-demographic correlates for the incidence of Crohn’s disease and ulcerative colitis. Amer J Epidemiol 2001; 154: 328–335.

    Article  CAS  Google Scholar 

  61. Lashner BA. Epidemiology of inflammatory bowel disease. Gastroenterol Clin N Am 1995; 24: 467–74.

    CAS  Google Scholar 

  62. Triantafillidis JK, Emmanouilidis A, Manousos O, Nicolakis D, Kogevinas M. Clinical patterns of Crohn’s disease in Greece: a follow up study of 155 cases. Digestion 2000; 61: 121–128.

    Article  PubMed  CAS  Google Scholar 

  63. Hassan K, Cowan FJ, Jenkins HR. The incidence of childhood inflammatory bowel disease in Wales. Eur J Pediatr 2000; 159: 261–263.

    Article  PubMed  CAS  Google Scholar 

  64. Weinstein TA, Levine M, Pettei M, Gold DM, Kessler BH. The influence of age and family history in the presentation of pediatric inflammatory bowel disease. Gastroenterol 2000; 118: A531.

    Google Scholar 

  65. Straus WL, Eisen GM, Sandler RS, Murray SC, Sessions JT, for the Mid-Atlantic Crohn’s Disease Study Group. Crohn’s disease: does race matter? Am J Gastroenterol 2000; 95: 479–483.

    Article  PubMed  CAS  Google Scholar 

  66. Wigley RD, MacLaurin BP. A study of ulcerative colitis in New Zealand, showing a low incidence in Maoris. Br Med J 1962; 2: 228–231.

    Article  PubMed  CAS  Google Scholar 

  67. Matsunaga F. Clinical studies of ulcerative colitis and its related diseases in Japan, in Proceedings of the World Congress on Gastroenterol Baltimore, Md, Williams and Wilkins, 1958.

    Google Scholar 

  68. Mendeloff AI, Dunn JP. Digestive diseases. American Public Health Association Vital and Health Statistics Monograph. Cambridge, MA: Harvard University Press, 1971.

    Google Scholar 

  69. Congilosi SM, Rosendale DE, Herman DL. Crohn’s disease-A rare disorder in American Indians. West J Med 1992; 157: 682 (letter).

    Google Scholar 

  70. Kurata JH, Kantor-Fish S, Frankl H, Godby P, Vadheim CM. Crohn’s disease among ethnic groups in a large Health Maintenance Organization. Gastroenterology 1992; 102: 1940–1948.

    PubMed  CAS  Google Scholar 

  71. Acheson ED. The distribution of ulcerative colitis and regional enteritis in United States Veterans with a particular reference to the Jewish religion. Gut 1960; 1: 291–293.

    Article  PubMed  CAS  Google Scholar 

  72. Gelpi AP. Inflammatory bowel disease among college students. West J Med 1978; 129: 369–373.

    PubMed  CAS  Google Scholar 

  73. Carr I, Mayberry JF. The effects of migration on ulcerative colitis:a three year prospective study among Europeans and first-and second-generation South Asians in Leicester (1991–1994) Am J Gastroenterol 1999; 94: 2918–2922.

    PubMed  CAS  Google Scholar 

  74. Probert CSJ, Jayanthi V, Hughes AO, Thompson JR, Wicks ACB, Mayberry JF. Prevalence and family risk of ulcerative colitis and Crohn’s disease: an epidemiological study among Europeans and South Asians in Leicestershire. Gut 1993; 34: 1547–1551.

    Article  PubMed  CAS  Google Scholar 

  75. Ekbom A, Wakefield AJ, Zack M, Adami HO. The role of perinatal measles infection in the aetiology of Crohn’s disease: a population-based epidemiological study. Lancet 1994; 344: 508–510.

    Article  PubMed  CAS  Google Scholar 

  76. Montgomery SM, Björnsson S, Jóhannsson JH, Thjodleifsson B, Pounder RE, Wakefield AJ. Concurrent viral epidemics in Iceland are a risk for inflammatory bowel disease. Gut 1998; 42: A41.

    Google Scholar 

  77. Montgomery SM, Morris DL, Pounder RE, Wakefield AJ. Paramyxovirus infections in childhood and subsequent inflammatory bowel disease Gastroenterology 1999; 116: 796–803.

    CAS  Google Scholar 

  78. Delco F, Sonnenberg A. Birth-cohort phenomenon in the time trends of mortality from ulcerative colitis. Am J Epidemiol 1999; 150: 359–366.

    Article  PubMed  CAS  Google Scholar 

  79. Rogers BHJ, Clark LM, Kirsner JB. The epidemiologic and demographic characteristics of inflammatory bowel disease-An analysis of a computerized file of 1400 patients. J Chronic Dis 1971; 24: 743–773.

    Article  PubMed  CAS  Google Scholar 

  80. Grace M, Priest G. The epidemiology of inflammatory bowel disease, in Inflammatory Bowel Disease:Crohn’s Disease and Chronic Ulcerative Colitis. ABR Thomson, ed. Canadian Public Health Association, Ottawa, Canada, 1982, pp. 52–66.

    Google Scholar 

  81. Monk M, Mendeloff AI, Siegel CE, et al. An epidemiological study of ulcerative colitis and regional enteritis among adults in Baltimore. II. Social and demographic factors. Gastroenterology 1969; 56: 947–957.

    Google Scholar 

  82. Bernstein CN, Kraut A, Blanchard JF, Rawsthorne P, Yu N, Walld R. The relationship between inflammatory bowel disease and socioeconomic variables. Amer J Gastroenterol 2001; 96: 2117–2125.

    Article  CAS  Google Scholar 

  83. Harries AD, Baird A, Rhodes J. Non-smoking: a feature of ulcerative colitis. Brit Med J 1982; 284: 706.

    Article  CAS  Google Scholar 

  84. Somerville KW, Logan RFA, Edmond M, Langman MJS. Smoking and Crohn’s disease. BMJ 1984; 289: 954–956.

    CAS  Google Scholar 

  85. Tragnone A, Hanau C, Bazzocchi G, et al. Epidemiological characteristics of inflammatory bowel disease in Bologna, Italy–incidence and risk factors. Digestion 1993; 54: 183–188.

    Article  PubMed  CAS  Google Scholar 

  86. Boyko EJ, Koepsell TD, Perera DR, et al. Risk of ulcerative colitis among former and current cigarette smokers. N Engl J Med 1987; 316: 707–710.

    Article  PubMed  CAS  Google Scholar 

  87. Lesko SM, Kaufman DW, Rosenberg L, et al. Evidence for an increased risk of Crohn’s disease in oral contraceptive users. Gastroenterology 1985; 89: 1046–1049.

    PubMed  CAS  Google Scholar 

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Authors
  1. Charles N. Bernstein MD
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  2. James F. Blanchard MD,PhD
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Editors and Affiliations

  1. Section of Gastroenterology, Department of Medicine, The University of Chicago Medical Center, Chicago, IL, USA

    Russell D. Cohen MD

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Bernstein, C.N., Blanchard, J.F. (2003). Epidemiology of Inflammatory Bowel Disease. In: Cohen, R.D. (eds) Inflammatory Bowel Disease. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-311-8_2

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  • DOI: https://doi.org/10.1007/978-1-59259-311-8_2

  • Publisher Name: Humana Press, Totowa, NJ

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