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Glutamate and Dopamine Interactions in the Motive Circuit

Implications for Craving

  • Chapter
Glutamate and Addiction

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Addiction to psychomotor stimulants is marked by a transition in drug consumption from a casual and recreational style of use to a more compulsive and excessive pattern. Acute administration of psychomotor stimulants is associated with numerous effects, including feelings of euphoria and increased energy, which can contribute to repeated recreational consumption. However, chronic administration of psychomotor stimulants results in the emergence of persistent cravings, paranoia, and drug-seeking behaviors that contribute to the development of compulsive drug-taking behavior (1–4). An understanding of the neurobiology of drug addiction will require the identification and characterization of neuroadaptations underlying this transition from casual to chronic drug use.

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Authors
  1. David A. Baker PhD
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  2. Jennifer L. Cornish PhD
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  3. Peter W. Kalivas PhD
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Editor information

Editors and Affiliations

  1. Clinical Medical Branch, Division of Treatment Research and Development, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Barbara H. Herman PhD

  2. Pharmacology, Integrative & Cellular Neurobiology Research Branch (PICNRB), Division of Neuroscience & Behavioral Research (DNBR), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Jerry Frankenheim PhD

  3. Treatment Research Branch, Division of Clinical and Prevention Research, National Institute on Drug Abuse (NIAAA), National Institutes of Health (NIH), Bethesda, MD, USA

    Raye Z. Litten PhD

  4. Division of Neuropharmacological Drug Products Center for Drug Evaluation and Research, Office of Drug Evaluation I, Food and Drug Administration, Rockville, MD, USA

    Philip H. Sheridan MD

  5. Laboratory of Molecular and Cellular Neurobiology, Division of Intramural Clinical and Biological Research, National Institute on Drug Abuse (NIAAA) National Institutes of Health (NIH), Bethesda, MD, USA

    Forrest F. Weight MD

  6. Division of Treatment Research and Development, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Steven R. Zukin MD

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© 2002 Springer Science+Business Media New York

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Baker, D.A., Cornish, J.L., Kalivas, P.W. (2002). Glutamate and Dopamine Interactions in the Motive Circuit. In: Herman, B.H., Frankenheim, J., Litten, R.Z., Sheridan, P.H., Weight, F.F., Zukin, S.R. (eds) Glutamate and Addiction. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-306-4_9

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  • DOI: https://doi.org/10.1007/978-1-59259-306-4_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-234-6

  • Online ISBN: 978-1-59259-306-4

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