Abstract
The N-methyl-D-asparate (NMDA) receptor is a complex subtype of the glutamatergic receptor system. Glutamate and aspartate are endogenous ligands binding to NMDA receptors. Activation of NMDA receptors can be blocked at either the glutamate-binding site or the regulatory sites. Although the role of NMDA receptors in opioid tolerance and dependence was initially examined using t-opioid agonists, studies have been carried out to investigate the effects of NMDA receptor antagonists on tolerance and dependence induced by κ-and σ-opioid agonists.
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Mao, J. (2002). Role of the Glutamatergic System in Opioid Tolerance and Dependence. In: Herman, B.H., Frankenheim, J., Litten, R.Z., Sheridan, P.H., Weight, F.F., Zukin, S.R. (eds) Glutamate and Addiction. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-306-4_19
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