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Methamphetamine Toxicity

Roles for Glutamate, Oxidative Processes, and Metabolic Stress

  • Chapter
Glutamate and Addiction

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Methamphetamine (MA) is a sympathomimetic amine with potent effects on the peripheral and central nervous systems, resulting in psychomotor activation, mood elevation, anorexia, increased mental alertness, enhanced physical endurance, and hyperthermia. The mood-elevating and positive-reinforcing effects most likely contribute to the high abuse liability of this drug. Indeed, MA abuse has increased across the United States at an alarming rate since the late 1980s. MA-related emergencies have increased sixfold in the past decade and 4–5 million people in the United States now report using MA at some time in their lives (1), highlighting the urgency for research on the pharmacology and toxicity of this drug.

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Authors
  1. Kristan B. Burrows PhD
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  2. Bryan K. Yamamoto PhD
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Editors and Affiliations

  1. Clinical Medical Branch, Division of Treatment Research and Development, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Barbara H. Herman PhD

  2. Pharmacology, Integrative & Cellular Neurobiology Research Branch (PICNRB), Division of Neuroscience & Behavioral Research (DNBR), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Jerry Frankenheim PhD

  3. Treatment Research Branch, Division of Clinical and Prevention Research, National Institute on Drug Abuse (NIAAA), National Institutes of Health (NIH), Bethesda, MD, USA

    Raye Z. Litten PhD

  4. Division of Neuropharmacological Drug Products Center for Drug Evaluation and Research, Office of Drug Evaluation I, Food and Drug Administration, Rockville, MD, USA

    Philip H. Sheridan MD

  5. Laboratory of Molecular and Cellular Neurobiology, Division of Intramural Clinical and Biological Research, National Institute on Drug Abuse (NIAAA) National Institutes of Health (NIH), Bethesda, MD, USA

    Forrest F. Weight MD

  6. Division of Treatment Research and Development, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, MD, USA

    Steven R. Zukin MD

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Burrows, K.B., Yamamoto, B.K. (2002). Methamphetamine Toxicity. In: Herman, B.H., Frankenheim, J., Litten, R.Z., Sheridan, P.H., Weight, F.F., Zukin, S.R. (eds) Glutamate and Addiction. Contemporary Clinical Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-306-4_14

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