Abstract
Early reports on the immunologic activity of ISS-ODN focused on its ability to induce natural killer (NK) cell activation, B-cell proliferation, and the production of type-1 cytokines such as IL-12, type 1 IFNs, and IFN-γ from antigen-presenting cells (APCs), B cells, and NK cells in an antigen independent manner (1–4). In addition to these effects, ISS-ODN has more recently been shown to increase the expression of various costimulatory molecules on APCs and B cells (Figs. 1 A,B) (5–7). Interestingly, although ISSODN induces an innate cytokine response and increased costimulatory molecule expression by several cell types, ISS-ODN does not appear to activate T cells directly (6,8).
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Kobayashi, H., Martin-Orozco, E., Takabayashi, K., Horner, A.A. (2002). Immunostimulatory DNA Prepriming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses. In: Raz, E. (eds) Microbial DNA and Host Immunity. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-305-7_13
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DOI: https://doi.org/10.1007/978-1-59259-305-7_13
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