Skip to main content
SpringerLink
Log in

Chromium Picolinate

  • Chapter
Dietary Supplements

Part of the book series: Forensic Science and Medicine ((FSM))

  • 318 Accesses

Abstract

Chromium supplements have been advertised to the general public since at least the early 1990s. Chromium was the second most frequently mentioned ingredient in a study of health and bodybuilding magazines purchased during the summer of 1991 (Philen et al., 1992).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allen LV. Handbook of Nonprescription Drugs, 12th ed. Washington, DC: American Pharmaceutical Association, 2000.

    Google Scholar 

  • Althius MD, Jordan NE, Ludington, EA, Wittes JT. Glucose and insulin responses to dietary chromium supplements: a meta-analysis. Am J Clin Nutr 2002; 76: 148–55.

    Google Scholar 

  • Amato P, Morales AJ, Yen SS. Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body composition in healthy, nonobese, older men and women. J Gerontol A Biol Sci Med Sci 2000; 55: 7260–3.

    Article  Google Scholar 

  • Anderson RA, Cheng N, Bryden NA, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with Type 2 Diabetes. Diabetes 1997; 46: 1786–91.

    Article  PubMed  CAS  Google Scholar 

  • Bunner SP, McGinnis R. Chromium-induced hypoglycemia [letter]. Pschosomatics 1998; 39: 298–9.

    Article  CAS  Google Scholar 

  • Campbell WW, Joseph LJO, Davey SL, et al. Effects of resistance training and chromium picolinate on body composition and skeletal muscle in older men. J Appl Physiol 1999; 86: 29–39.

    PubMed  CAS  Google Scholar 

  • Cerulli J, Grabe DW, Gauthier I, Malone M, McGoldrick MD. Chromium picolinate toxicity. Ann Pharmacother 1998; 32: 428–31.

    Article  PubMed  CAS  Google Scholar 

  • Clancy SP, Clarkson PM, DeCheke ME, et al. Effects of chromium picolinate supplementation on body composition, strength, and urinary chromium loss in football players. Int J Sports Med 1994; 4: 142–53.

    CAS  Google Scholar 

  • Dazzi C, Candiano G, Massazza S, Ponzetto A, Varesio L. New high-performance liquid chromatographic method for the detection of picolinic acid in biological fluids. J Chromatogr B Biomed Sci Appl 2001; 751: 61–68.

    Article  PubMed  CAS  Google Scholar 

  • Evans GW. The effect of chromium picolinate on insulin controlled parameters in humans. Int J Biosocial Med Res 1989; 11: 163–80.

    Google Scholar 

  • Fowler JF. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000; 65: 116.

    PubMed  Google Scholar 

  • Gargas ML, Norton RL, Paustenbach DJ, Finley BL. Urinary excretion of chromium by humans following ingestion of chromium picolinate. Drug Metab Dispos 1994; 22: 522–9.

    Google Scholar 

  • Hallmark MA, Reynolds TH, DeSouza CA, et al. Effects of chromium and resistive training on muscle strength and body composition. Med Sci Sports Exerc 1996; 28: 139–44.

    Article  PubMed  CAS  Google Scholar 

  • Hasten DL, Rome EP, Franks DB, Hegsted M. Effect of chromium picolinate on beginning weight training students. Int J Sport Nutr 1992; 2: 343–50.

    PubMed  CAS  Google Scholar 

  • Hopkins LL. Distribution in the rat of physiological amounts of Cr (III) with time. Am J Physiol 1965; 209: 731–5.

    PubMed  Google Scholar 

  • Huszonek J. Over-the-counter chromium picolinate [letter]. Am J Psychiatry 1993; 150: 1560–1.

    PubMed  CAS  Google Scholar 

  • Institute of Medicine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. 2002. Available from: URL: http://www.nap.edu/books/0309072794/html/. Accessed 121–0002.

    Google Scholar 

  • Kaats GR, Blum K, Fisher JA, Adelman JA. Effects of chromium picolinate supplementation on body composition: a randomized, double-masked, placebo-controlled study. Curr Ther Res 1996; 57: 747–56.

    Article  CAS  Google Scholar 

  • Kaats GR, Blum K, Pulin D, Keith SC, Wood R. A randomized, double-masked, placebo-controlled study of the effects of chromium picolinate supplementation on body composition: a replication and extension of a previous study. Curr Ther Res 1998; 59: 379–88.

    Article  CAS  Google Scholar 

  • Lukaski HC, Bolonchuk WW, Siders WA, Milne DB. Chromium supplementation and resistance training: effects on body composition, strength, and trace element status of men. Am J Clin Nutr 1996; 63: 954–65.

    PubMed  CAS  Google Scholar 

  • Martin WR, Fuller RE. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 1998; 18: 860–2.

    PubMed  CAS  Google Scholar 

  • McCarty MF. Over-the-counter chromium and renal failure [letter]. Ann Intern Med 1997; 127: 654–5.

    Article  PubMed  CAS  Google Scholar 

  • Naritsin DB, Boni RL, Markey SP. Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry. Anal Chem 1995; 67: 863–70.

    Article  PubMed  CAS  Google Scholar 

  • Philen RM, Ortiz DU, Auerbach SB, Falk H. Survey of advertising for nutritional supplements in health and bodybuilding magazines. JAMA 1992; 268: 1008–11.

    Article  PubMed  CAS  Google Scholar 

  • Press RI, Geller J, Evans GW. The effect of chromium picolinate on serum cholesterol and apolipoprotein fractions in human subjects. West J Med 1990; 152: 41–5.

    PubMed  CAS  PubMed Central  Google Scholar 

  • Ravina A, Slezak L, Mirsky N, Bryden NA, Anderson RA. Reversal of corticosteroids-induced diabetes mellitus with supplemental chromium. Diabet Med 1999; 16: 164–7.

    Article  PubMed  CAS  Google Scholar 

  • Speetjens JK, Collins RA, Vincent JB, Woski SA. The nutritional supplement chromium (III) tris(picolinate) cleaves DNA. Chem Res Toxicol 1999; 12: 483–7.

    Article  PubMed  CAS  Google Scholar 

  • Stearns DM, Belbruno JJ, Wetterhahn KE. A prediction of chromium(III) accumulation in humans form chromium dietary supplements. FASEB J 1995a; 9: 1650–7.

    PubMed  CAS  Google Scholar 

  • Stearns DM, Wise JP, Patierno SR, Wetterhahn KE. Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. FASEB J 1995b; 9: 1643–9.

    PubMed  CAS  Google Scholar 

  • Tandon SK, Saxena DK, Gaur JS, Chandra SV. Comparative toxicity of trivalent and hexavalent chromium: alterations in blood and liver. Environ Res 1978; 15: 90–9.

    Article  PubMed  CAS  Google Scholar 

  • Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995; 35: 273–80.

    PubMed  CAS  Google Scholar 

  • Veillon C, Patterson KY, Bryden NA. Chromium in urine as measured by atomic absorption spectrometry. Clin Chem 1982; 28: 2309–11.

    PubMed  CAS  Google Scholar 

  • Wasser WG, Feldman NS, D’Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate [letter]. Ann Intern Med 1997a; 126: 410.

    Article  PubMed  CAS  Google Scholar 

  • Wasser WG, Yusuf SA, D’Agati VD. In response [letter]. Ann Intern Med 1997b; 127: 656.

    Article  Google Scholar 

  • Young PC, Turiansky GW, Bonner MW, Benson PM. Acute generalized exanthematous pustulosis indued by chromium picolinate. J Am Acad Dermatol 1999; 41: 820–3.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Aleshia R. Haslacker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Melanie Johns Cupp
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Timothy S. Tracy
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. West Virginia University, Morgantown, WV, USA

    Melanie Johns Cupp PharmD, BCPS  & Timothy S. Tracy PhD  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Haslacker, A.R., Cupp, M.J., Tracy, T.S. (2003). Chromium Picolinate. In: Cupp, M.J., Tracy, T.S. (eds) Dietary Supplements. Forensic Science and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-303-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-303-3_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9726-7

  • Online ISBN: 978-1-59259-303-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation