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Shark Cartilage

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Dietary Supplements

Part of the book series: Forensic Science and Medicine ((FSM))

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Abstract

Hammerhead sharks of the Sphyridae family have inhabited oceans for over 300 million years (Pettit and Ode, 1977), and the Chinese have been consuming shark cartilage in the form of shark fin soup for hundreds of years (Lane and Cormac, 1991). Shark cartilage has been used medicinally since the 1950s for treatment of many conditions, including the pain and swelling associated with osteoarthritis and rheumatoid arthritis, and for arthritis prevention (Miller et al., 1998). Squalene, which is isolated from shark stomachs, has been used in skin therapy, wrinkle prevention, and scar healing. It is also believed to have antibiotic activity against protozoa, fungi, and gram-positive and gram-negative bacteria (Marshall, 1996).

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References

  • Anonymous. AE 941—Neovastat. Drugs R D 1999a; 1: 135–6.

    Article  Google Scholar 

  • Anonymous. Shark cartilage costly last resort for cancer patients. Alt Med Alert 1999b; 2: 24.

    Google Scholar 

  • Ashar B, Vargo E. Shark cartilage-induced hepatitis. Ann Intern Med 1996; 125: 780–1.

    Article  PubMed  CAS  Google Scholar 

  • Berbari P, Thibodeau A, Germain L, et al. Anti-angiogenic effects of the oral administration of liquid shark cartilage extract in humans. J Surg Res 1999; 87: 108–13.

    Article  PubMed  CAS  Google Scholar 

  • Cockin GH, Huckerby TN, Nieduszynski IA. High-field N.M.R. studies of keratan sulphates. 1H and 13C assignments of keratan sulphate from shark cartilage. Biochem J 1986; 236: 921–4.

    PubMed  CAS  PubMed Central  Google Scholar 

  • Havlick, HD. Looking at Lane Labs: compassion, quality, solutions. Natural Pharmacy 1999; 3: 1, 12–3.

    Google Scholar 

  • Kinoshita A, Sugahara K. Microanalysis of glycosaminoglycan-derived oligosaccharides labeled with a fluorophore 2-aminobenzamide by high-performance liquid chromatography: application to disaccharide composition analysis and exosequencing of oligosaccharides. Anal Biochem 1999; 269: 367–78.

    Article  PubMed  CAS  Google Scholar 

  • Lane IW, Comac L. Sharks don’t get cancer. Garden City, NY: Avery Publishing Group, 1992.

    Google Scholar 

  • Lee A, Langer R. Shark cartilage contains inhibitors of tumor angiogenesis. Science 1983; 221: 1185–7.

    Article  PubMed  CAS  Google Scholar 

  • Marshall J. Shark cartilage for cancer treatment? P and T Newslett Exchange 1996; 21: 159–60.

    Google Scholar 

  • McGuire TR, Kazakoff PW, Hoie EB, et al. Antiproliferative activity of shark cartilage with and without tumor necrosis factor-alpha in human umbilical vein endothelium. Pharmaco- therapy 1996; 16: 237–44.

    CAS  Google Scholar 

  • Miller DR, Anderson GT, Stark JJ, et al. Phase I/II trial of the safety and efficacy of shark cartilage in the treatment of advanced cancer. J Clin Oncol 1998; 16: 3649–55.

    PubMed  CAS  Google Scholar 

  • Morris GM, Coderre JA, Micca PL, et al. Boron neutron capture therapy of the rat 9L gliosarcoma: evaluation of the effects of shark cartilage. Br J Radiol 2000; 73: 429–34.

    Article  PubMed  CAS  Google Scholar 

  • NCI. Office of Cancer Complementary and Alternative Medicine. Available from:URL: www3.cancer.gov/occam/trials.html. Accessed January 31, 2002.

    Google Scholar 

  • Pettit GR, Ode RH. Antineoplastic agents I: isolation and characterization of sphyrnastatins 1 and 2 from the hammerhead shark Sphyma lewini. J Pharm Sci 1977; 66: 757–8.

    Article  PubMed  CAS  Google Scholar 

  • Real Life. What is shark cartilage. Available from: URL: http://www.realife.com. Accessed Oc- tober 9, 2000.

    Google Scholar 

  • Volpi N. Hyaluronic acid and chondroitin sulfate unsaturated disaccharides analysis by high-performance liquid chromatography and fluorimetric detection with dansylhydrazine. Anal Biochem 2000; 277: 19–24.

    Article  PubMed  CAS  Google Scholar 

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© 2003 Springer Science+Business Media New York

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Pettrey, K.J., Cupp, M.J., Tracy, T.S. (2003). Shark Cartilage. In: Cupp, M.J., Tracy, T.S. (eds) Dietary Supplements. Forensic Science and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-303-3_22

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  • DOI: https://doi.org/10.1007/978-1-59259-303-3_22

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9726-7

  • Online ISBN: 978-1-59259-303-3

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