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Neural Stem Cells and Their Plasticity

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Neural Stem Cells for Brain and Spinal Cord Repair

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Stem cells are functional units in both development and tissue homeostasis and can be found in a variety of embryonic and adult mammalian tissues. These cells are thought to arise from totipotent embryonic stem (ES) cells of the inner cell mass of the blastocyst from which distinct groups of precursors segregate into the three main germ layers (ectoderm, mesoderm, and endoderm) at around the time of gastrulation. Gradually, these cells will mature into fate-restricted organ- and tissue-specific somatic stem cells (SCs) (1), which are responsible for the growth of tissues during development. The number of SCs declines when the tissues approach maturity and remains rather constant throughout life.

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Authors
  1. Angela Gritti
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  2. Angelo Vescovi
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  3. Rossella Galli
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Editors and Affiliations

  1. Center for Aging and Brain Repair, Departments of Neurosurgery, Anatomy and Pharmacology, University of South Florida College of Medicine, Tampa, FL, USA

    Tanja Zigova PhD

  2. Department of Neurology, Harvard Medical School, Harvard Institutes of Medicine & Beth Israel-Deaconess Medical Center, Division of Newborn Medicine, Children’s Hospital-Boston, Boston, MA, USA

    Evan Y. Snyder MD, PhD

  3. Center for Aging and Brain Repair, Departments of Neurosurgery, Neurology, Psychiatry and Pharmacology, University of South Florida College of Medicine, Tampa, FL, USA

    Paul R. Sanberg PhD, DSc

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Gritti, A., Vescovi, A., Galli, R. (2003). Neural Stem Cells and Their Plasticity. In: Zigova, T., Snyder, E.Y., Sanberg, P.R. (eds) Neural Stem Cells for Brain and Spinal Cord Repair. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-298-2_2

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  • DOI: https://doi.org/10.1007/978-1-59259-298-2_2

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