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Neural Stem Cells for Brain and Spinal Cord Repair pp 411–429Cite as

Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

This chapter will review laboratory experiments using human neuroteratocarcinoma cells (hNT cells, also called NT2N cells and LBS neurons) in animal models of neurological disorders. Because NT2N cells are originally derived from adult human cancerous tumors engineered to become neuron-like cells, their use for transplantation therapy eliminates logistical problems associated with the use of fetal and embryonic stem cells. This chapter will focus on functional recovery in stroke animals that received NT2N cell grafts. In light of recent studies demonstrating expression of trophic factors by NT2N cells, such trophic factor property of the cells is presented here as a plausible mechanism underlying the behavioral effects of transplanted NT2N cells. An overview on the clinical report of NT2N cell grafts in stroke patients will also be provided.

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Authors
  1. Cesario V. Borlongan
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  2. Paul R. Sanberg
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Editors and Affiliations

  1. Center for Aging and Brain Repair, Departments of Neurosurgery, Anatomy and Pharmacology, University of South Florida College of Medicine, Tampa, FL, USA

    Tanja Zigova PhD

  2. Department of Neurology, Harvard Medical School, Harvard Institutes of Medicine & Beth Israel-Deaconess Medical Center, Division of Newborn Medicine, Children’s Hospital-Boston, Boston, MA, USA

    Evan Y. Snyder MD, PhD

  3. Center for Aging and Brain Repair, Departments of Neurosurgery, Neurology, Psychiatry and Pharmacology, University of South Florida College of Medicine, Tampa, FL, USA

    Paul R. Sanberg PhD, DSc

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Borlongan, C.V., Sanberg, P.R. (2003). Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy. In: Zigova, T., Snyder, E.Y., Sanberg, P.R. (eds) Neural Stem Cells for Brain and Spinal Cord Repair. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-298-2_16

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  • DOI: https://doi.org/10.1007/978-1-59259-298-2_16

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-298-8

  • Online ISBN: 978-1-59259-298-2

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