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Sources of Cells for CNS Therapy

  • Chapter
Book cover Neural Stem Cells for Brain and Spinal Cord Repair

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

The goal in transplant therapy is to provide adequate numbers of cells to appropriate sites for useful cellular replacement. In principle, three types of therapy can be considered. One straightforward therapeutic approach is to use dissociated cells for replacement. In this approach, either purified populations of cells or mixed populations of cells can be used. A second therapeutic approach is to develop devices that are a combination of synthetic material and cells. A third possibility is to use stem cells and precursor cells to generate organs in culture. These synthetic organs can then be transplanted. Each of these approaches has been tried with varied amounts of success. Generating organs has been possible for some structures such as skin, blood vessels, lens, and bone (see ref. 1 and references therein), but the inherent complexity of even the simplest neural structures currently renders this an impractical approach for the nervous system. A combination of synthetic material and cells have been used in retinal implants, cochlear replacements, nerve electrode junctions, synthetic neural networks or guidance channels for nerve regrowth. These devices are still in developmental stages and a detailed discussion of such devices is beyond the scope of this chapter. In this chapter, we have limited our discussion to the relative advantages and disadvantages of the various human cell types that are available for dissociated cell replacement therapy.

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Authors
  1. Melissa K. Carpenter
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  2. Mark Mattson
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  3. Mahendra S. Rao
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Editors and Affiliations

  1. Center for Aging and Brain Repair, Departments of Neurosurgery, Anatomy and Pharmacology, University of South Florida College of Medicine, Tampa, FL, USA

    Tanja Zigova PhD

  2. Department of Neurology, Harvard Medical School, Harvard Institutes of Medicine & Beth Israel-Deaconess Medical Center, Division of Newborn Medicine, Children’s Hospital-Boston, Boston, MA, USA

    Evan Y. Snyder MD, PhD

  3. Center for Aging and Brain Repair, Departments of Neurosurgery, Neurology, Psychiatry and Pharmacology, University of South Florida College of Medicine, Tampa, FL, USA

    Paul R. Sanberg PhD, DSc

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Carpenter, M.K., Mattson, M., Rao, M.S. (2003). Sources of Cells for CNS Therapy. In: Zigova, T., Snyder, E.Y., Sanberg, P.R. (eds) Neural Stem Cells for Brain and Spinal Cord Repair. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-298-2_1

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  • DOI: https://doi.org/10.1007/978-1-59259-298-2_1

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