Abstract
Microglia are normally quiescent, mesoderm-derived brain macrophages and are the resident immunocompetent cells of the central nervous system (CNS). In conditions of intact blood-brain barrier when blood-borne cells are largely absent, microglia, together with perivascular cells, are the first line of the brain’ s immune defense system. Any even subtle or subacute neuronal insult/damage induces an activation of resting microglial cells. Activated microglia produce a widespread variety of pro-inflammatory molecules, change their morphology, and, if cell death occurs, finally mature into full-blown macrophages (1).
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Cagnin, A., Gerhard, A., Banati, R.B. (2003). In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases. In: Wood, P.L. (eds) Neuroinflammation. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-297-5_20
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DOI: https://doi.org/10.1007/978-1-59259-297-5_20
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4684-9720-5
Online ISBN: 978-1-59259-297-5
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