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Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury

  • Chapter
Neuroinflammation

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Acute traumatic spinal cord injury (SCI) is an unexpected, catastrophic event, the consequences of which often persist for the life of the patient and influence in diverse ways not only the patient but also family members and society at large. Only limited therapeutic measures are currently available for its treatment (1). SCI induced by trauma is a consequence of an initial physical insult followed by a progressive injury process that involves various pathochemical events that lead to tissue destruction (1,2). Although prevention programs have been initiated, there is no evidence that the incidence is declining. Therefore, during the acute phase, therapeutic intervention in SCI should be directed at reducing or alleviating this secondary process. Although the mechanisms involved in the secondary injury process are not fully understood, the activated leukocyte-induced vascular damage leading to neuroinflammation has been postulated to be one of the important pathomechanisms of acute spinal cord injury (3–6).

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Authors
  1. Yuji Taoka
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  2. Kenji Okajima
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Editors and Affiliations

  1. Oxon Medica, South San Francisco, CA, USA

    Paul L. Wood

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© 2003 Humana Press Inc., Totowa, NJ

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Taoka, Y., Okajima, K. (2003). Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury. In: Wood, P.L. (eds) Neuroinflammation. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-297-5_10

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  • DOI: https://doi.org/10.1007/978-1-59259-297-5_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9720-5

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