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Pneumocystis carinii

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Opportunistic Infections

Part of the book series: Infectious Disease ((ID))

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Abstract

With the advent of the AIDS pandemic in the last 15 years or so, the number of P. carinii pneumonia (PCP) cases has risen dramatically (1–6), establishing P. carinii pneumonia as the first life-threatening opportunistic infection recognized in AIDS (3–5,7), occuring as the initial manifestation in 50–60% of cases (8–10). It has been estimated that as many as 80% of AIDS patients may develop PCP at least once (11,12).

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References

  1. Coolfont Report. A PHS plan for prevention and control of AIDS and the AIDS virus. Publ. Health Rep., 101, 341, 1986.

    Google Scholar 

  2. Hopewell, P. C. Pneumocystis carinii pneumonia: diagnosis. J. Infect. Dis., 137, 1115, 1988.

    Article  Google Scholar 

  3. Gottlieb, M. S., Schroff, R., Schanker, H. M., et al. Pneumocystis carinii pneumonia and mucosal candiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N. Engl. J. Med., 305, 1425, 1981.

    Article  PubMed  CAS  Google Scholar 

  4. Masur, H., Michelis, M. A., Greene, J. B., et al. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N. Engl. J. Med., 305, 1431, 1981.

    Article  PubMed  CAS  Google Scholar 

  5. Centers for Disease Control. Pneumocystic pneumonia: Los Angeles. Morbid. Mortal. Wkly Rep., 30, 250, 1981.

    Google Scholar 

  6. Kim, B., Lyons, T. M., Parada, J. P., et al. HIV- related Pneumocystis carinii pneumonia in older patients hospitalized in the early HAART era. J. Gen. Intern. Med., 16, 583–589, 2001 [see also: J. Gen. Intern. Med., 16, 583–589, 2001 ].

    CAS  Google Scholar 

  7. Centers for Disease Control. Kaposi’s sarcoma and pneumocystic pneumonia among homosexual men: New York City and California. Morb. Mortal. Wkly Rep., 30, 305, 1981.

    Google Scholar 

  8. Lipschik, G. Y. and Masur, H. Pneumocystis carinii pneumonia (PCP), in Prog. Clin. Parasitol., vol. 2, Sun, T., Ed. Field and Wood, New York, 27, 1991.

    Google Scholar 

  9. Curran, J. W., Morgan, W. M., Hardy, A. M., Jaffe, H. W., Darrow, W. W., and Dowdle, W. R. The epidemiology of AIDS: current status and future prospects. Science, 229, 1352, 1985.

    Article  PubMed  CAS  Google Scholar 

  10. Centers for Disease Control. Update: acquired immunodeficiency syndrome: United States. Morb. Mortal. Wkly Rep., 34, 245, 1985.

    Google Scholar 

  11. Centers for Disease Control. Update: acquired immunodeficiency syndrome: United States. Morb. Mortal. Wkly Rep., 35, 542, 1986.

    Google Scholar 

  12. Murray, J. F., Garay, S. M., Hopewell, P. C., Mills, J., Snider, G. L., and Stover, D. G. NHLBI workshop summary: pulmonary complications of the acquired immune deficiency syndrome: an update. Am. Rev. Respir. Dis., 135, 504, 1987.

    PubMed  CAS  Google Scholar 

  13. Hughes, W. T. Pneumocystis carinii pneumonitis. N. Engl. J. Med., 317, 1021, 1987.

    Article  PubMed  CAS  Google Scholar 

  14. Haron, E., Bodey, G. P., Luna, M. A., Dekmezian, R., and Elting, L. Has the incidence of Pneumocystis carinii pneumonia in cancer patients increased with the AIDS epidemic? Lancet, 2, 904, 1988.

    Article  PubMed  CAS  Google Scholar 

  15. Thaker, H., Snow, M. H., Spickett, G., Griffin, S. M., and Gascoigne, A. Pneumocystis carinii pneumonia after thoracic duct ligation and leakage. Clin. Infect. Dis., 33, E129 — E231, 2001.

    Article  PubMed  CAS  Google Scholar 

  16. Cardenal, R., Medrano, F. J., Varela, J. M., et al. Pneumocystis carinii pneumonia in heart transplant recipients. Eur. J. Cardiothorac. Surg., 20, 799–802, 2001.

    Article  PubMed  CAS  Google Scholar 

  17. Kawamura, T., Sando, Y., Tajima, S., et al. Pulmonary intravascular lymphoma complicated with Pneumocystis carinii pneumonaia: a case report. Jpn. J. Clin. Oncol., 31, 333–336, 2001.

    Article  PubMed  CAS  Google Scholar 

  18. Toledo, A. C., Jr. and de Castro, M. R. Pneumocystis carinii pneumonia, pulmonary tuberculosis and visceral leishmaniasis in an adult HIV negative patient. Braz. J. Infect. Dis., 5, 154–157, 2001.

    PubMed  Google Scholar 

  19. Fishman, J. A. Prevention of infection caused by Pneumocystis carinii in transplant patients. Clin. Infect. Dis., 33, 1397–1405, 2001.

    Article  PubMed  CAS  Google Scholar 

  20. Groll, A. H., Ritter, J., and Muller, F. M. Guidelines for prevention of Pneumocystis carinii pneumonitis in children and adolescents with cancer. Klin. Padiatr., 213 (Suppl. 1), A38 — A49, 2001.

    Article  PubMed  Google Scholar 

  21. Dykewicz, C. A., Centers for Disease Control and Prevention (U.S.), Infectious Diseases Society of America, American Society of Blood and Marrow Transplantation. Summary of the guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Clin. Infect. Dis., 33, 139–144, 2001.

    Article  PubMed  CAS  Google Scholar 

  22. Saito, T., Seo, S., Kanda, Y., et al. Early onset Pneumocystis carinii pneumonia after allogeneic peripheral blood stem cell transplantation. Am. J. Hematol., 67, 206–209, 2001.

    Article  PubMed  CAS  Google Scholar 

  23. Burke, B. A. and Good, R. A. Pneumocystis carinii infection. Medicine (Baltimore), 52, 23, 1973.

    CAS  Google Scholar 

  24. Walzer, P. D., Schultz, M. G., Western, K. A., and Robbins, J. B. Pneumocystis carinii pneumonia and primary immune deficiency diseases of infancy and childhood. J. Pediatr., 82, 416, 1973.

    Article  PubMed  CAS  Google Scholar 

  25. Leggiadro, R. J., Winkelstein, J. A., and Hughes, W. T. Prevalence of Pneumocystis carinii pneumonitis in severe combined immunodeficiency. J. Pediatr., 99, 96, 1981.

    Article  PubMed  CAS  Google Scholar 

  26. Rao, C. P. and Gelfand, E. W. Pneumocystis carinii pneumonitis in patients with hypogammaglobulinemia and intact T cell immunity. J. Pediatr., 103, 410, 1983.

    Article  PubMed  CAS  Google Scholar 

  27. Lederman, H. and Winkelstein, J. A. Congenital agammaglobulinemia: the clinical course of 88 patients. Pediatr. Res., 17, 254A, 1983.

    Google Scholar 

  28. Dutz, W., Post, C., Vessai, K., and Kohout, E. Endemic infantile Pneumocystis carinii infection: the Shiraz study. Natl. Cancer Inst. Monogr., 43, 31, 1976.

    PubMed  CAS  Google Scholar 

  29. Hughes, W. T., Price, R. A., Sisko, F., et al. Protein-calorie malnutrition: a host determinant for Pneumocystis carinii pneumonia. Am. J. Dis. Child., 128, 44, 1974.

    PubMed  CAS  Google Scholar 

  30. Tsai, H. C., Lee, S. S., Lin, H. H., Lu, L. Y., and Liu, Y. C. Pneumocystis carinii pneumonia in systemic lupus erythematosus: a report of two cases. J. Formos. Med. Assoc., 100, 699–702, 2001.

    PubMed  CAS  Google Scholar 

  31. Sharma, C. P., Chaudhary, D., and Behera, D. Pneumocystis carinii pneumonia in a patient with active untreated systemic lupus erythematosus. Indian J. Chest Dis. Allied Sci., 43, 169–171, 2001.

    PubMed  CAS  Google Scholar 

  32. Ikawa, H., Hayashi, Y., Ohbayashi, C., Tankawa, H., and Itoh, H. Autopsy case of alcoholic hepatitis and cirrhosis treated with corticosteroids and affected by Pneumocystis carinii and cytomegalovirus pneumonia. Pathol. Int., 51, 629–632, 2001.

    Article  PubMed  CAS  Google Scholar 

  33. Sing, A., Geiger, A. M., Hogardt, M., and Heesemann, J. Pneumocystis carinii carriage among cystic fibrosis patients, as detected by nested PCR. J. Clin. Microbiol., 39, 2717–2718, 2001.

    Article  PubMed  CAS  Google Scholar 

  34. Hughes, W. T. Pneumocystis carinii pneumonia, in Infections and the Compromised Host: Clinical Correlations and Therapeutic Approaches, 2nd ed., Allen, J. C., Ed. Williams and Wilkins, Baltimore, 91, 1981.

    Google Scholar 

  35. Hughes, W. T. Pneumocystis carinii Pneumonitis. CRC Press, Boca Raton, 1987.

    Google Scholar 

  36. Gajdusek, D. C. Pneumocystis carinii: etiologic agent of interstitial plasma cell pneumonia of premature and young infants. Pediatrics, 19, 543, 1957.

    PubMed  CAS  Google Scholar 

  37. Dutz, W., Jennings-Khodadad, E., Post, C., Kohout, E., Nazarian, I., and Esmaili, H. Marasmus and Pneumocystis carinii pneumonia in institutionalized infants. Z. Kinderheilkd., 117, 241, 1974.

    Article  PubMed  CAS  Google Scholar 

  38. Gleason, W. A., Roden, V. J., and Decastro, E. Pneumocystis pneumonia in Vietnamese infants. J. Pediatr., 87, 1001, 1975.

    Article  PubMed  Google Scholar 

  39. Varthalitis, I. and Meunier, F. Pneumocystis carinii pneumonia in cancer patients. Cancer Treat. Rev., 19, 387, 1993.

    Article  PubMed  CAS  Google Scholar 

  40. Varthalitis, I., Aoun, M., Daneau, D., and Meunier, F. Pneumocystis carinii pneumonia in patients with cancer: an increasing incidence. Cancer, 71, 481, 1993.

    Article  PubMed  CAS  Google Scholar 

  41. Sepkowitz, K. A. Pneumocystis carinii pneumonia among patients with neoplastic disease. Semin. Respir. Dis., 7, 114, 1992.

    CAS  Google Scholar 

  42. Hughes, W. T., Sanyal, S. K., and Price, R. A. Signs, symptoms, and pathophysiology of Pneumocystis carinii. Natl. Cancer Inst. Monogr., 43, 77, 1976.

    CAS  Google Scholar 

  43. Lipson, A., Marshall, W. C., and Hayward, A. R. Treatment of Pneumocystis carinii in children. Arch. Dis. Child., 52, 314, 1977.

    Article  PubMed  CAS  Google Scholar 

  44. Bernstein, C. N., Kolodny, M., Block, E., and Shanahan, F. Pneumocystis carinii pneumonia in patients with ulcerative colitis treated with corticosteroids. Am. J. Gastroenterol., 88, 574, 1993.

    PubMed  CAS  Google Scholar 

  45. Liam, C. K. and Wang, F. Pneumocystis carinii pneumonia in patients with systemic lupus erythematosus. Lupus, 1, 379, 1992.

    Google Scholar 

  46. Tuan, I. Z., Dennison, D., and Weisdorf, D. J. Pneumocystis carinii pneumonitis followed bone marrow transplantation. Bone Marrow Transplant., 10, 267, 1992.

    PubMed  CAS  Google Scholar 

  47. Lim, K. L., Powell, R. J., and Johnston, I. D. Pneumocystis carinii pneumonia following immunosuppressive therapy in systemic lupus erythematosus. Br. J. Rheumatol., 31, 643, 1992.

    Article  PubMed  CAS  Google Scholar 

  48. Porter, D. R., Marshall, D. A. S., Madhok, R., Capell, H., and Sturrock, R. D. Pneumocystis carinii infection complicating cytotoxic therapy in two patients with lymphopenia, but a normal total white cell count. Br. J. Rheumatol., 31, 71, 1992.

    Article  PubMed  CAS  Google Scholar 

  49. Kingsmore, S. F. and Schwab, S. J. Pneumonia due to Pneumocystis carinii in a transplant recipient with normal arterial oxygen tension and normal radiographic findings. South. Med. J., 86, 1052, 1993.

    Article  PubMed  CAS  Google Scholar 

  50. Epstein, L. J., Meyer, R. D., Antonson, S., Strigle, S. M., and Mohsenifar, Z. Persistence of Pneumocystis carinii in patients with AIDS receiving chemoprophylaxis. Am. J. Respir. Crit. Care Med., 150 (5 Part 1), 1456, 1994.

    PubMed  CAS  Google Scholar 

  51. Knox, D. L. and Green, W. R. Pneumocystis carinii granuloma of the optic nerve: a histopathologic case report. J. Neuroophthalmol., 21, 274–275, 2001.

    Article  PubMed  CAS  Google Scholar 

  52. Miller, R. F., Ambrose, H. E., and Wakefield, A. E. Pneumocystis carinii f. sp. hominis DNA in immunocompetent health care workers in contact with patients with P. carinii pneumonia. J. Clin. Microbiol., 39, 3877–3882, 2001.

    Article  PubMed  CAS  Google Scholar 

  53. Kovacs, J. A., Hiemenz, J. W., Macher, A. M., et al. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann. Intern. Med., 100, 663, 1984.

    PubMed  CAS  Google Scholar 

  54. Safrin, S. Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Semin. Respir. Med., 8, 96, 1993.

    CAS  Google Scholar 

  55. Sterling, R. P., Bradley, B. B., Khalil, K. G., Kerman, R. H., and Conklin, R. H. Comparison of biopsy-proven Pneumocystis carinii pneumonia in acquired immune deficiency syndrome patients and renal allograft recipients. Ann. Thorac. Surg., 38, 494, 1984.

    Article  PubMed  CAS  Google Scholar 

  56. Haverkos, H. W. Assessment of therapy for Pneumocystis carinii pneumonia: PCP therapy project group. Am. J. Med., 76, 501, 1984.

    Article  PubMed  CAS  Google Scholar 

  57. Staikowsky, F., Lafon, B., Guidet, B., Denis, M., Mayaud, C., and Offenstadt, G. Mechanical ventilation for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Chest, 104, 756, 1993.

    Article  PubMed  CAS  Google Scholar 

  58. Ahmad, H., Mehta, N. J., Manikal, V. M., et al. Pneumocystis carinii pneumonia in pregnancy. Chest, 120, 666–671, 2001.

    Google Scholar 

  59. Ognibene, F. P., Shelhamer, J. H., Hoffman, G. S., et al. Pneumocystis carinii pneumonia: a major complication of immunosuppressive therapy in patients with Wegener’s granulomatosis. Am. J. Respir. Crit. Care Med., 151 (3 part 1), 795, 1995.

    PubMed  CAS  Google Scholar 

  60. Jarrousse, B., Guillevin, L., Bindi, P., et al. Increased risk of Pneumocystis carinii pneumonia in patients with Wegener’s granulomatosis. Clin. Exp. Rheumatol., 11, 615, 1993 [published erratum appeared in Clin. Exp. Rheumatol., 12, 117, 1994 ].

    Google Scholar 

  61. Abernathy-Carver, K. J., Fan, L. L., Boguniewicz, M., Larsen, G. L., and Leung, D. Y. Legionella and Pneumocystis pneumonias in asthmatic children on high doses of systemic steroids. Pediatr. Pulmonol., 18, 135, 1994.

    Article  PubMed  CAS  Google Scholar 

  62. Smulian, A. G. Pneumocystis carinii: genetic diversity and cell biology. Fungal Genet. Biol., 34, 145–154, 2001.

    Article  PubMed  CAS  Google Scholar 

  63. Volpe, G., Sbaiz, L., Avanzini, C., Caramello, P., and Savoia, D. Genetic diversity of Pneumocystis carinii isolated from human immunodeficiency virus-positive patients in Turin, Italy. J. Clin. Microbiol., 39, 2995–2997, 2001.

    Article  PubMed  CAS  Google Scholar 

  64. Ambrose, H. E., Ponce, C. A., Wakefield, A. E., Miller, R. F., and Vargas, S. L. Distribution of Pneumocystis carinii f. sp. hominis types in the lung of a child dying of Pneumocystis carinii. Clin. Infect. Dis., 33, eí00-e102, 2001.

    Google Scholar 

  65. Helweg-Larsen, J., Lundgren, B., and Lundgren, J. D. Heterogeneity and compartmentalization of Pneumocystis carinii. J. Clin. Microbiol., 39, 3789–3792, 2001.

    Article  CAS  Google Scholar 

  66. Navin, T. R., Beard, C. B., Huang, L., et al. Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P. carinii pneumonia in patients with HIV-1: a prospective stidy. Lancet, 358, 545–549, 2001.

    Article  PubMed  CAS  Google Scholar 

  67. Woodward, S. C. and Sheldon, W. H. Subclinical Pneumocystis carinii pneumonitis in adults. Bull. Johns Hopkins Hosp., 109, 148, 1961.

    PubMed  CAS  Google Scholar 

  68. Hamlin, W. B. Pneumocystis carinii. J. Am. Med. Assoc., 204, 171, 1968.

    Google Scholar 

  69. Esterly, J. A. Pneumocystis carinii in lungs of adults at autopsy. Am. Rev. Respir. Dis., 97, 935, 1968.

    PubMed  CAS  Google Scholar 

  70. Meuwissen, J. H., Tauber, I., Leeuwenberg, A. D., Beckers, P. J., and Sieben, M. Parasitologic and serologic observations of infection with pneumocystis in humans. J. Infect. Dis., 136, 43, 1977.

    Article  PubMed  CAS  Google Scholar 

  71. Pifer, L. L., Hughes, W. T., Stagno, S., and Woods, D. Pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressed children. Pediatrics, 61, 35, 1978.

    PubMed  CAS  Google Scholar 

  72. Kovacs, J. A., Halpern, J. L., Swan, J. C., Moss, J., Parrillo, J. E., and Masur, H. Identification of antigens and antibodies specific for Pneumocystis carinii. J. Immunol., 140, 2023, 1988.

    CAS  Google Scholar 

  73. Smith, D. E., McLuckie, A., Wyatt, J., and Gazzard, B. Severe exercise hypoxaemia with normal or near-normal x-rays: a feature of Pneumocystis carinii infection. Lancet, 2, 1049, 1988.

    Article  PubMed  CAS  Google Scholar 

  74. Israel, H. L., Gottlieb, J. E., and Schulman, E. S. Hypoxemia with normal chest roentgenogram due to Pneumocystis carinii pneumonia: diagnostic errors due to a low suspicion of AIDS. Chest, 92, 857, 1987.

    Article  PubMed  CAS  Google Scholar 

  75. Kennedy, C. A. and Goetz, M. B. Atypical roentgenographic manifestations of Pneumocystis carinii pneumonia. Arch. Intern. Med., 152, 1390, 1992.

    Article  PubMed  CAS  Google Scholar 

  76. Peters, J. W. and Sattler, F. R. Atypical Pneumocystis carinii pneumonia: the potential hazards of empiric treatment. South. Med. J., 76, 800, 1983.

    Article  PubMed  CAS  Google Scholar 

  77. Cross, A. S. and Steigbigel, R. T. Pneumocystis carinii pneumonia presenting as localized nodular densities. N. Engl. J. Med., 291, 831, 1974.

    Article  PubMed  CAS  Google Scholar 

  78. Hartz, J. W., Geisinger, K. R., Scharyj, M., and Muss, H. B. Granulomatous pneumocystosis presenting as a solitary pulmonary nodule. Arch. Pathol. Lab. Med., 109, 466, 1985.

    PubMed  CAS  Google Scholar 

  79. Barrio, J. L., Suarez, M., Rodriguez, J. L., Saldana, M. J., and Pitchenik, A. E. Pneumocystis carinii pneumonia presenting as cavitating and noncavitating solitary pulmonary nodules in patients with the acquired immunodeficiency syndrome. Am. Rev. Respir. Dis., 134, 1094, 1986.

    PubMed  CAS  Google Scholar 

  80. Bleiweiss, I. J., Jagirdar, J. S., Klein, M. J., et al. Granulomatous Pneumocystis carinii pneumonia in three patients with the acquired immune deficiency syndrome. Chest, 94, 580, 1986.

    Article  Google Scholar 

  81. Byrd, R. B. and Horn, B. R. Infection due to Pneumocystis carinii stimulating lobar bacterial pneumonia. Chest, 70, 91, 1976.

    Article  PubMed  CAS  Google Scholar 

  82. Stokes, D. C., Shenep, J. L., Horowitz, M. E., and Hughes, W. T. Presentation of Pneumocystis carinii pneumonia as unilateral hyperlucent lung. Chest, 94, 201, 1988.

    Article  PubMed  CAS  Google Scholar 

  83. Abd, A. G., Nierman, D. M., Ilowite, J. S., Pierson, R. N. Jr., and Bell, A. L. Jr. Bilateral upper lobe Pneumocystis carinii pneumonia in a patient receiving inhaled pentamidine prophylaxis. Chest, 94, 329, 1988.

    Article  PubMed  CAS  Google Scholar 

  84. Oki, Y., Kami, M., Kishi, Y., et al. Pneumocystis carinii pneumonia with an atypical granulomatous response in a patient with chronic lymphocytic leukemia. Leuk. Lymphoma, 41, 435–438, 2001.

    Article  PubMed  CAS  Google Scholar 

  85. Albrecht, H., Stellbrink, H. J., Fenske, S., Koch, J., and Greten, H. A novel variety of atypical Pneumocystis carinii infection after long-term prophylactic pentamidine inhalation in an AIDS patient. Clin. Invest., 71, 310, 1993.

    Article  CAS  Google Scholar 

  86. Srivatsa, S. S., Burger, C. D., and Douglas, W. W. Upper lobe pulmonary parenchymal calcification in a patient with AIDS and Pneumocystis carinii pneumonia receiving aerosolized pentamidine. Chest, 101, 266, 1992.

    Article  PubMed  CAS  Google Scholar 

  87. Anderson, C. D. and Barrie, B. M. Fatal Pneumocystis pneumonia in an adult. Am. J. Clin. Pathol., 34, 365, 1960.

    PubMed  CAS  Google Scholar 

  88. Livingstone, C. B. Pneumocystis pneumonia occuring in a family with agammaglobulinemia. Can. Med. Assoc. J., 90, 1223, 1964.

    PubMed  CAS  Google Scholar 

  89. Sundar, K., Rosado-Santos, H., Reimer, L., Murray, K., and Michael, J. Unusual presentation of thoracic Pneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. Clin. Infect. Dis., 32, 498–501, 2001.

    Article  PubMed  CAS  Google Scholar 

  90. Barnett, R. N., Hull, J. G., Vortel, V., and Schwartz, J. Pneumocystis carinii in lymph nodes and spleen. Arch. Pathol., 88, 175, 1969.

    CAS  Google Scholar 

  91. Awen, C. F. and Baltzan, M. A. Systemic dissemination of Pneumocystis carinii pneumonia. Can. Med. Assoc. J., 104, 809, 1971.

    PubMed  CAS  Google Scholar 

  92. Roder, V. H. and Kleine-Natrop, H. E. Morphologischer zufallsbefund von Pneumocystis carinii in stromenden blut bei erythema nodosum. Derm. Mschr., 157, 678, 1971.

    CAS  Google Scholar 

  93. LeGolvan, D. P. and Heidelberger, K. P. Disseminated granulomatous Pneumocystis carinii pneumonia. Arch. Pathol., 95, 344, 1973.

    PubMed  CAS  Google Scholar 

  94. Price, R. A. and Hughes, W. T. Histopathology of Pneumocystis carinii infestation and infection in malignant disease in childhood. Hum. Pathol., 5, 737, 1974.

    Article  PubMed  CAS  Google Scholar 

  95. Rahimi, S. A. Disseminated Pneumocystis carinii in thymic alymphoplasia. Arch. Pathol., 97, 162, 1974.

    PubMed  CAS  Google Scholar 

  96. Henderson, D. W., Humeniuk, V., Meadows, R., and Forbes, I. J. Pneumocystis carinii pneumonia with vascular and lymph nodal involvement. Pathology, 6, 235, 1974.

    Article  PubMed  CAS  Google Scholar 

  97. Kwok, S., O’Donnell, J. J., and Wood, I. S. Retinal cotton-wool spots in a patient with Pneumocystis carinii infection. N. Engl. J. Med., 307, 184, 1982.

    PubMed  CAS  Google Scholar 

  98. Rossi, J. F., Dubois, A., Bengler, C., et al. Pneumocystis carinii in bone marrow. Ann. Intern. Med., 102, 868, 1985.

    Google Scholar 

  99. Delage, A., Bengler, C., Ross, J. F., Marin, J., and Lauraine, M. C. Pneumocystis carinii dans la moelle osseuse. Bull. Soc. Path. E., 78, 478, 1985.

    CAS  Google Scholar 

  100. Coulman, C. U., Greene, I., and Archibald, R. W. Cutaneous pneumocystosis. Ann. Intern. Med., 106, 396, 1987.

    PubMed  CAS  Google Scholar 

  101. Grimes, M. M., LaPook, J. D., Bar, M. H., Wasserman, H. S., and Dwork, A. Disseminated Pneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. Hum. Pathol., 18, 307, 1987.

    Article  PubMed  CAS  Google Scholar 

  102. Schinella, R. A., Breda, S. D., and Hammerschlag, P. E. Otic infection due to Pneumocystis carinii in an apparently healthy man with antibody to the human immunodeficiency virus. Ann. Intern. Med., 106, 399, 1987.

    PubMed  CAS  Google Scholar 

  103. Macher, A. M., Bardenstein, D. S., Zimmerman, L. E., et al. Pneumocystis carinii chorioditis in a male homosexual with AIDS and disseminated pulmonary and extrapulmonary P. carinii infection. N. Engl. J. Med., 316, 1092, 1987.

    PubMed  CAS  Google Scholar 

  104. Pilon, V. A., Echols, R. M., Celo, J. S., and Elmendorf, S. L. Disseminated Pneumocystis carinii infection in AIDS. N. Engl. J. Med., 316, 1410, 1987.

    Article  PubMed  CAS  Google Scholar 

  105. Steigman, C. K., Pastore, L., Park, C. H., et al. Case for diagnosis: AIDS. Milit. Med., 152, Ml, 1987.

    Google Scholar 

  106. Carter, T. R., Cooper, P. H., Petri, W. A. Jr., Kim, C. K., Walzer, P. D., and Guerrant, R. L. Pneumocystis carinii infection of the small intestine in a patient with acquired immune deficiency. Am. J. Clin. Pathol., 89, 79, 1988.

    Google Scholar 

  107. Gallant, J. E., Enriquez, R. E., Cohen, K. L., and Hammers, L. W. Pneumocystis carinii thyroiditis. Am. J. Med., 84, 303, 1988.

    Article  PubMed  CAS  Google Scholar 

  108. Gherman, C. R., Ward, R. R., and Bassis, M. L. Pneumocystis carinii otitis and mastoiditis as the initial manifestation of the acquired immunodeficiency syndrome. Am. J. Med., 85, 250, 1988.

    Article  PubMed  CAS  Google Scholar 

  109. Patel, S. K., Philpott, J. M., and McPartlin, D. W. An unusual case of Pneumocystis carinii presenting as an aural mass. J. Laryngol. Otol., 113, 555–557, 1999.

    PubMed  CAS  Google Scholar 

  110. Unger, P. D., Rosenblum, M., and Krown, S. E. Disseminated Pneumocystis carinii infection in a patient with acquired immunodeficiency syndrome. Hum. Pathol., 19, 113, 1988.

    Article  PubMed  CAS  Google Scholar 

  111. Hagman, S., Merall, S., Sitnitskaya, Y., Fefferman, N., and Pollack, H. Pneumocystis carinii infection presenting as an intra-abdominal cystic mass in a child with acquired immunodeficiency syndrome. Clin. Infect. Dis., 33, 1424–1426, 2001.

    Article  Google Scholar 

  112. Dugel, P. V., Rao, N. A., Forster, D. J., Chong, L. P., Frangieh, G. T., and Sattler, F. Pneumocystis carinii choroiditis after long-term aerosolized pentamidine therapy. Am. J. Ophthalmol., 110, 113, 1990.

    PubMed  CAS  Google Scholar 

  113. Rao, N. A., Zimmerman, P. L., Boyer, D., et al. A clinical, histopathologic and electron microscopic study of Pneumocystis carinii choroiditis. Am. J. Ophthalmol., 107, 218, 1989.

    PubMed  CAS  Google Scholar 

  114. Lalonde, L., Allaire, G. S., Sebag, M., Lamer, L., Marcil, G., and Gervais, A. Pneumocystis carinii choroidopathy and aerosolized pentamidine prophylaxis in a patient with AIDS. Can. J. Ophthalmol., 28, 291, 1993.

    PubMed  CAS  Google Scholar 

  115. Freeman, W. R., Gross, J. G., Labelle, J., Oteken, K., Katz, B., and Wiley, C. A. Pneumocystis carinii choroidopathy, a new clinical entry. Arch. Ophthalmol., 107, 863, 1989.

    Article  PubMed  CAS  Google Scholar 

  116. Armstrong, D. and Bernard, E. Aerosol pentamidine. Ann. Intern. Med., 109, 852, 1988.

    PubMed  CAS  Google Scholar 

  117. Hagopian, W. A. and Huseby, J. S. Pneumocystis hepatitis and choroiditis despite successful aerosolized pentamidine pulmonary prophylaxis. Chest, 96, 949, 1989.

    Article  PubMed  CAS  Google Scholar 

  118. Smith, M. A., Hirschfield, L. S., Zahtz, G., and Siejal, F. P. Pneumocystis carinii otitis media. Am. J. Med., 85, 745, 1988.

    Article  PubMed  CAS  Google Scholar 

  119. Breda, S. D., Gigliotti, F., Hammerschlag, P. E., and Schinella, R. Pneumocystis carinii in the temporal bone as a primary manifestation to the acquired immunodeficiency syndrome. Ann. Otol. Rhinol. Laryngol., 97, 427, 1988.

    PubMed  CAS  Google Scholar 

  120. Sandler, E. D., Sandler, J. M., LeBoit, P. E., Wenig, B. M., and Mortensen, N. Pneumocystis carinii otitis media in AIDS: a case report and review of the literature regarding extrapulmonary pneumocystosis. Otolaryngol. Head Neck Surg., 103, 817, 1990.

    CAS  Google Scholar 

  121. Patey, O., Salvanet, A., Serrhini, A., and Lafaix, C. Pneumocystis carinii in AIDS patients. AIDS, 7, 1015, 1993.

    Article  PubMed  CAS  Google Scholar 

  122. Sha, B. E., Benson, C. A., Deutsch, T., et al. Pneumocystis carinii chorioditis in patients with AIDS: clinical features, response to therapy, and outcome. J. Acquir. Immune Defic. Syndr., 5, 1051, 1992.

    Google Scholar 

  123. Edman, U., Edman, J. C., and Santi, D. Isolation and expression of the Pneumocystis carinii thymidate synthase gene. Proc. Natl. Acad. Sci. USA, 86, 6503, 1989.

    Article  PubMed  CAS  Google Scholar 

  124. Drucker, D. J., Bailey, D., and Rotstein, L. Thyroiditis as the presenting manifestation of disseminated extrapulmonary Pneumocystis carinii infection. J. Clin. Endocrinol. Metab., 71, 1663, 1990.

    Article  PubMed  CAS  Google Scholar 

  125. Delorenzo, L. J., Huang, C. T., Maguire, G. P., and Stone, D. J. Roentgenographic patterns of Pneumocystis carinii pneumonia in 104 patients with AIDS. Chest, 91, 323, 1987.

    Article  PubMed  CAS  Google Scholar 

  126. Dyner, T. S., Lang, W., Busch, D. F., and Gordon, P. R. Intravascular and pleural involvement by Pneumocystis carinii in a patient with AIDS. Ann. Intern. Med., 111, 94, 1989.

    PubMed  CAS  Google Scholar 

  127. Mariuz, P., Raviglione, M. C., Gould, I. A., and Mullen, M. P. Pleural Pneumocystis carinii infection. Chest, 99, 774, 1991.

    Article  PubMed  CAS  Google Scholar 

  128. Telzak, E. E., Cote, R. J., Gold, J. W. M., Campbell, S. W., and Armstrong, D. Extrapulmonary Pneumocystis carinii infections. Rev. Infect. Dis., 12, 380, 1990.

    Article  PubMed  CAS  Google Scholar 

  129. Witt, K., Nielsen, T. N., and Junge, J. Dissemination of Pneumocystis carinii in patients with AIDS. Scand. J. Infect. Dis., 23, 691, 1991.

    Article  PubMed  CAS  Google Scholar 

  130. Hennessey, N. P., Parro, E. L., and Cockerell, C. J. Cutaneous Pneumocystis carinii infection in patients with acquired immunodeficiency syndrome. Arch. Dermatol., 127, 1699, 1991.

    Article  PubMed  CAS  Google Scholar 

  131. Lecuit, M., Livartowski, J., Vons, C., et al. Resistance to trimethoprim-sulfamethoxazole and sensitivity to pentamidine therapy in an AIDS patient with hepatosplenic pneumocystosis. AIDS, 8, 1506, 1994.

    Article  PubMed  CAS  Google Scholar 

  132. Northfelt, D., Michael, J., and Safrin, J. Extrapulmonary pneumocystosis: clinical features in human immunodeficiency infection. Medicine (Baltimore), 89, 392, 1990.

    Google Scholar 

  133. Bazin, C., Hazera, P., Greder, A., et al. Extrapulmonary disseminated pneumocystosis in HIV infection. Presse Med., 22, 161, 1993.

    PubMed  CAS  Google Scholar 

  134. Raviglione, M. C. Extrapulmonary pneumocystosis: the first 50 years. Rev. Infect. Dis., 12, 1127, 1990.

    Article  PubMed  CAS  Google Scholar 

  135. Poblete, R. B., Rodriguez, K., Foust, R. T., Reddy, K. R., and Saldana, M. J. Pneumocystis carinii hepatitis in the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med., 110, 737, 1989.

    PubMed  CAS  Google Scholar 

  136. Jarnum, S., Rasmussen, E. F., Ohlsen, A. S., and Sorensen, A. W. Generalized Pneumocystis carinii infection with severe idiopathic hypoproteinemia. Ann. Intern. Med., 68, 138, 1968.

    PubMed  CAS  Google Scholar 

  137. Agarwal, J., Agarwal, G., Ayyagari, A., Kar, D. K., Mishra, S. K., and Bhatia, E. Isolated Pneumocystis carinii infection of adrenal glands causing Addison’s disease in a non-immunocompromised adult. Endocr. Pathol., 12, 87–91, 2001.

    Article  PubMed  CAS  Google Scholar 

  138. Tugwell, P., Bennett, K., and Gent, M. Methotrexate in rheumatoid arthritis. Ann. Intern. Med., 107, 418, 1987.

    Google Scholar 

  139. Perruquet, J. L., Harrington, T. M., and Davis, D. E. Pneumocystis carinii pneumonia following methotrexate therapy for rheumatoid arthritis. Arthritis Rheum., 26, 1291, 1983.

    Article  PubMed  CAS  Google Scholar 

  140. Seideman, P., Müller-Suur, R., and Ekman, E. Renal effect of low dose methotrexate in rheumatoid arthritis. J. Rheumatol., 20, 1126, 1993.

    PubMed  CAS  Google Scholar 

  141. Marshall, D., Sturrock, R. D., Porter, D., and Capell, H. A. Pneumocystis carinii complicating low dose methotrexate treatment for rheumatoid arthritis. Thorax, 47, 67, 1992.

    Article  PubMed  CAS  Google Scholar 

  142. Kane, G. C., Troshinsky, M. B., Peters, S. P., and Israel, H. L. Pneumocystis carinii pneumonia associated with weekly methotrexate: cumulative dose of methotrexate and low CD4 cell count may predict this complication. Respir. Med., 87, 153, 1993.

    Article  PubMed  CAS  Google Scholar 

  143. Krebs, S. and Gibbons, R. B. Low-dose methotrexate as a risk factor for Pneumocystis carinii. Mil. Med., 161, 58–60, 1996.

    CAS  Google Scholar 

  144. Leff, R. L., Case, J. P., and McKenzie, R. Rheumatoid arthritis, methotrexate therapy, and Pneumocystis carinii. Ann. Intern. Med., 112, 716, 1990.

    CAS  Google Scholar 

  145. Wollner, A., Mohle-Boetani, J., Lambert, R. E., Perruquet, J. L., Raffin, T. A., and Mcguire, J. L. Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis. Thorax, 46, 205, 1991.

    Article  PubMed  CAS  Google Scholar 

  146. Wallis, P. J. W., Ryatt, K. S., and Constable, T. J. Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for psoriatic arthropathy. Ann. Rheum. Dis., 48, 247, 1989.

    Article  PubMed  CAS  Google Scholar 

  147. Olson, N. J., Callahan, L. F., and Pincus, T. Immunologic studies of rheumatoid arthritis patients treated with methotrexate. Arthritis Rheum., 30, 481, 1987.

    Article  Google Scholar 

  148. Dawson, T., Ryan, P. F. J., Findeisen, J. M., and Scheinkestel, C. D. Pneumocystis carinii pneumonia following cyclosporine A and methotrexate treated rheumatoid arthritis. J. Rheumatol., 19, 997, 1992.

    PubMed  CAS  Google Scholar 

  149. Powles, A. V., Baker, B. S., and Fry, L. Cyclosporine toxicity. Lancet, 335, 610, 1990.

    Article  PubMed  CAS  Google Scholar 

  150. Hammoudeh, M., Siam, A.-R., and Khanjar, I. Renal effect of low dose methotrexate in rheumatoid arthritis. J. Rheumatol., 21, 1168, 1994.

    PubMed  CAS  Google Scholar 

  151. Schneider, M. M. E., Hoepelman, A. I. M., Eeftinck Schattenkerk, J. K., et al. A controlled trial of aerosolized pentamidine or trimethoprim-sulfamethoxazole as primary prophylaxis against Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection. N. Engl. J. Med., 327, 1836, 1992.

    Article  PubMed  CAS  Google Scholar 

  152. Calabrese, L. H., Taylor, J. V., Wilke, W. S., Segal, A. M., Valenzuela, R., and Clough, J. D. Response of immunoregulatory lymphocyte subsets to methotrexate in rheumatoid arthritis. Cleve. Clin. J. Med., 57, 232, 1990.

    PubMed  CAS  Google Scholar 

  153. Houtman, P. M., Stenger, A. A. M. E., Bruyn, G. A. W., and Mulder, J. Methotrexate may affect certain T lymphocyte subsets in rheumatoid arthritis resulting in susceptibility to Pneumocystis carinii infection. J. Rheumatol., 21, 1168, 1994.

    PubMed  CAS  Google Scholar 

  154. Sohen, S., Kita, H., and Tanaka, S. Abnormalities in bone marrow mononuclear cells in patients with rheumatoid arthritis. J. Rheumatol., 20, 12, 1993.

    PubMed  CAS  Google Scholar 

  155. Gibbons, J. J. and Lucas, J. Immunomodulation by low dose methotrexate. I. Methotrexate selectively inhibits Lyt-2’ cells in murine graft-versus-host reactions. J. Immunol., 142, 1867, 1989.

    PubMed  CAS  Google Scholar 

  156. Fischl, M. A., Richman, D. D., Grieco, M. H., et al. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex: a double-blind, placebo-controlled trial. N. Engl. J. Med., 317, 185, 1987.

    Article  PubMed  CAS  Google Scholar 

  157. Fischl, M. A., Dickinson, G. M., and La Voie, L. Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocystis carinii pneumonia in AIDS. J. Am. Med. Assoc., 259, 1185, 1988.

    Article  CAS  Google Scholar 

  158. Davey, R. T. and Masur, H. Recent advances in the diagnosis, treatment and prevention of Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother., 34, 499, 1990.

    Article  PubMed  Google Scholar 

  159. Graham, N. M., Zeger, S. L., Park, L. P., et al. Effect of zidovudine and Pneumocystis carinii prophylaxis on progression of HIV-1 infection to AIDS. Lancet, 338, 265, 1991.

    Article  PubMed  CAS  Google Scholar 

  160. Gearhart, M. O. and Bhutani, M. S. Intravenous pentamidine-induced bronchospasm. Chest, 102, 1891, 1992.

    Article  PubMed  CAS  Google Scholar 

  161. Efferen, L. S., Nabarajah, D., and Palat, D. S. Survival following mechanical ventilation for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome: a different perspective. Am. J. Med., 87, 401, 1989.

    Article  PubMed  CAS  Google Scholar 

  162. El-Sadr, W. and Simberkoff, M. S. Survival and prognostic factors in severe Pneumocystis carinii pneumonia requiring mechanical ventilation. Am. Rev. Respir. Dis., 137, 1264, 1988.

    PubMed  CAS  Google Scholar 

  163. Brenner, M., Ognibene, F. P., Lack, E. E., et al. Prognostic factors and life expectancy of patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. Am. Rev. Respir. Dis., 136, 1199, 1987.

    Article  PubMed  CAS  Google Scholar 

  164. Thibert, J., Gasparini, A., Diaz-Mitoma, F., et al., Tolerance of oral trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis of Pneumocystis carinii pneumonia (PCP). Proc. 9th Int. Conf. AIDS, Berlin, abstract PO-B09–1397, 368, 1993.

    Google Scholar 

  165. Siegel, S. E., Wolff, L. J., Baehner, R. L., and Hammond, D. Treatment of Pneumocystis carinii pneumonitis: a comparative trial of sulfamethoxazole-trimethoprim vs. pentamidine in pediatric patients with cancer: report from the Children’s Cancer Study Center. Am. J. Dis. Child., 138, 1051, 1984.

    PubMed  CAS  Google Scholar 

  166. Vöhringer, H.-F. and Arastéh, K. Pharmacokinetic optimisation in the treatment of Pneumocystis carinii pneumonia. Clin. Pharmacokinet., 24, 388, 1993.

    Article  PubMed  Google Scholar 

  167. Wharton, J. M., Coleman, D. L., Wofsy, C. B., et al. Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Ann. Intern. Med., 105, 37, 1986.

    PubMed  CAS  Google Scholar 

  168. Gordin, F. M., Simon, G. L., Wofsy, C. B., and Mills, J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann. Intern. Med., 100, 495, 1984.

    PubMed  CAS  Google Scholar 

  169. Masur, H. and Kovacs, J. A. Treatment and prophylaxis of Pneumocystis carinii pneumonia. Infect. Dis. Clin. North Am., 2, 419, 1988.

    CAS  Google Scholar 

  170. Hughes, W. T., Feldman, S., Chaudhary, S. C., Ossi, M. J., Cox, F., and Sanyal, S. K. Comparison of pentamidine isethionate and trimethoprim-sulfamethoxazole in the treatment of Pneumocystis carinii pneumonia. J. Pediatr., 92, 285, 1978.

    Article  PubMed  CAS  Google Scholar 

  171. Jaffe, H. S., Abrams, D. I., Ammann, A. J., Lewis, B. J., and Golden, J. A. Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men. Lancet, 2, 1109, 1983.

    Article  PubMed  CAS  Google Scholar 

  172. Hughes, W. T., Feldman, S., and Sanyal, S. K. Treatment of Pneumocystis carinii pneumonitis with trimethoprimsulfamethoxazole. Can. Med. Assoc. J., 112, 47, 1975.

    PubMed  CAS  Google Scholar 

  173. Hughes, W. T., Kuhn, S., Chaudhary, S., et al. Successful chemoprophylaxis for Pneumocystis carinii pneumonia. N. Engl. J. Med., 297, 1419, 1977.

    Article  PubMed  CAS  Google Scholar 

  174. Wolff, L. J. and Baehner, R. L. Delayed development of pneumocystis pneumonia following administration of short-term high-dose trimethoprim-sulfamethoxazole. Am. J. Dis. Child., 132, 525, 1978.

    PubMed  CAS  Google Scholar 

  175. Chusid, M. J. and Heyrman, B. A. An outbreak of Pneumocystis carinii pneumonia at a pediatric hospital. Pediatrics, 62, 1031, 1978.

    PubMed  CAS  Google Scholar 

  176. Harris, R. E., McCallister, J. A., Allen, S. A., Barton, A. S., and Baehner, R. L. Prevention of pneumocystis pneumonia: use of continuous sulfamethoxazole-trimethoprim therapy. Am. J. Dis. Child., 134, 35, 1980.

    PubMed  CAS  Google Scholar 

  177. Wilber, R. B., Feldman, S., Malone, W. J., Ryan, M., Aur, R. J., and Hughes, W. T. Chemoprophylaxis for Pneumocystis carinii: outcome of unstructured delivery. Am. J. Dis. Child., 134, 643, 1980.

    PubMed  CAS  Google Scholar 

  178. Perrone, C., Bricaire, F., Leport, C., Assan, D., Vildé, J. L., and Assan, R. Hypoglycaemia and diabetes mellitus following parenteral pentamidine mesylate treatment in AIDS patients. Diabet. Med., 7, 585, 1990.

    Article  Google Scholar 

  179. Kovacs, J. A. and Masur, H. Pneumocystis carinii pneumonia: therapy and prophylaxis. J. Infect. Dis., 158, 254, 1988.

    Article  PubMed  CAS  Google Scholar 

  180. Ivady, G. and Paldy, L. Ein neves behandlungsverfahren der interstitiellen plasmazelligen pneumonie fruhgeborener mit fünfwerigen stibium und aromatischen diamidien. Monatsschr. Kinderheilkd., 106, 10, 1958.

    PubMed  CAS  Google Scholar 

  181. Mallory, D. L., Parrillo, J. E., Bailey, K. R., et al. Cardiovascular effects and safety of intravenous and intramuscular pentamidine isethionate. Crit. Care Med., 15, 503, 1987.

    Article  PubMed  CAS  Google Scholar 

  182. Conte, J. E., Hollander, H., and Golden, J. Inhaled or reduced-dose intravenous pentamidine for Pneumocystis carinii pneumonia. Ann. Intern. Med., 107, 495, 1987.

    PubMed  Google Scholar 

  183. Sattler, F. R. and Feinberg, J. New development in the treatment of Pneumocystis carinii pneumonia. Chest, 101, 451, 1992.

    Article  PubMed  CAS  Google Scholar 

  184. Monk, J. P. and Benfield, P. Inhaled pentamidine: an overview of its properties and a review of its therapeutic use in Pneumocystis carinii pneumonia. Drugs, 39, 741, 1990.

    Article  PubMed  CAS  Google Scholar 

  185. Navin, T. R. and Fontaine, R. E. Intravenous versus intramuscular administration of pentamidine. N. Engl. J. Med., 311, 1701, 1984.

    PubMed  CAS  Google Scholar 

  186. Montgomery, A. B., Debs, R. J., Luce, J. M., et al. Aerosolized pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet, 2, 480, 1987.

    Article  PubMed  CAS  Google Scholar 

  187. O’Doherty, M. J., Thomas, S., Page, C., et al. Diferrences in relative efficacy of nebulizers for pentamidine administration. Lancet, 2, 1283, 1988.

    Article  PubMed  Google Scholar 

  188. Armstrong, D. and Bernard, E. Aerosol pentamidine. Ann. Intern. Med., 109, 852, 1988.

    PubMed  CAS  Google Scholar 

  189. Yamamoto, H., Koizumi, T., Miyahara, T., Kaneki, T., and Kubo, K. Serial pentamidine levels in bronchial epithelial lining fluid after aerosol administration. Respiration, 68, 506–508, 2001.

    Article  PubMed  CAS  Google Scholar 

  190. Klein, N. C., Duncanson, F. P., Lenox, T. H., et al. Trimethoprim-sulfamethoxazole versus pentamidine for Pneumocystis carinii pneumonia in AIDS patients: results of a large prospective randomized treatment trial. AIDS, 6, 301, 1992.

    Article  PubMed  CAS  Google Scholar 

  191. Lentino, J. R. and Brooks, D. Pneumocystis carinii pneumonia and tuberculosis in a human immunodeficiency virusseronegative patient without evidence of the idiopathic CD4+ T lymphopenia syndrome. Clin. Infect. Dis., 18, 470, 1994.

    Article  PubMed  CAS  Google Scholar 

  192. Smith, D. K., Neal, J. J., and Holinberg, S. D. Unexplained opportunistic infections and CD4+ T-lymphocytopenia without HIV infection: an investigation of cases in the United States. The Centers for Disease Control Idiopatic CD4+ T-lymphocytopenia Task Force. N. Engl. J. Med., 328, 373, 1993.

    Article  PubMed  CAS  Google Scholar 

  193. Tijhuis, G. J., Huisman, H. G., and Kauffmann, R. H. AIDS without detectable HIV: a case report. Am. J. Med., 94, 442, 1993.

    Article  PubMed  CAS  Google Scholar 

  194. Lawrence, J. T-cell subsets in health, infectious disease, and idiopathic CD4+ T lymphopenia. Ann. Intern. Med., 119, 55, 1993.

    Google Scholar 

  195. World Health Organization. Unexplained severe immunosuppression without incidence of HIV infection. WHO Wkly Epidem. Rec., 42, 309, 1992.

    Google Scholar 

  196. Jayes, R. L., Kamerow, H. N., Hasselquist, S. M., Delaney, M. D., and Parenti, D. M. Disseminated pneumocystosis presenting as a pleural effusion. Chest, 103, 306, 1993.

    Article  PubMed  CAS  Google Scholar 

  197. Price, D. A., Hollings, N. P., Janes, S. M., Main, J., and Coker, R. J. Clinical response to the addition of clarithromycin in Pneumocystis carinii pneumonia refractory to high dose co-trimoxazole. J. Antimicrob. Chemother., 34, 303, 1994.

    Article  PubMed  CAS  Google Scholar 

  198. Hughes, W. T. The role of atovaquone tablets in treating Pneumocystis carinii pneumonia. J. Acquir. Immune Defic. Syndr. Human Retrovirol., 8, 247, 1995.

    Article  CAS  Google Scholar 

  199. Falloon, J., Kovacs, J., Hughes, W., et al. A preliminary evaluation of 566C80 for the treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med., 325, 1534, 1991.

    Article  PubMed  CAS  Google Scholar 

  200. Hughes, W., Leoung, G., Kramer, F., et al. Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS. N. Engl. J. Med., 328, 1521, 1993.

    Article  PubMed  CAS  Google Scholar 

  201. Dohn, M. N., Weinberg, W. G., Tones, R. A., et al. Oral atovaquone compared with intravenous pentamidine for Pneumocystis carinii pneumonia in patients with AIDS. Ann. Intern. Med., 121, 174, 1994.

    PubMed  CAS  Google Scholar 

  202. Lieberman, M. M., van der Horst, C., Stoeckle, M., and Tennenberg, A. Atovaquone for Pneumocystis carinii pneumonia. Ann. Intern. Med., 122, 314, 1995.

    Google Scholar 

  203. Masur, H. Prevention and treatment of Pneumocystis carinii. N. Engl. J. Med., 327, 1853, 1992.

    Article  PubMed  CAS  Google Scholar 

  204. Ashar, N., Daneshvar, H., and Beall, G. Desensitization to trimethoprim-sulfamethoxazole in HIV-infected patients. J. Allergy Clin. Immunol., 93, 1001, 1994.

    Article  Google Scholar 

  205. Leoung, G. S., Mills, J., Hopewell, P. C., Hughes, W., and Wofsy, C. Dapsone-trimethoprim for Pneumocystis carinii pneumonia in the acquired immunodeficency syndrome. Ann. Intern. Med., 105, 45, 1986.

    PubMed  CAS  Google Scholar 

  206. Kovacs, J. A., Allegra, C. J., Beaver, J., Boarman, D., and Lewis, M. Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents. J. Infect. Dis., 160, 312, 1989.

    Article  PubMed  CAS  Google Scholar 

  207. Kovacs, J. A., Powell, F., Voeller, D., and Allegra, C. J. Inhibition of Pneumocystis carinii dihydropteroate synthetase by para-acetamidobenzoic acid: possible mechanism of action of isoprinosine in human immunodeficiency virus infection. Antimicrob. Agents Chemother., 37, 1227, 1993.

    Article  PubMed  CAS  Google Scholar 

  208. Hughes, W. T. and Smith, B. L. Efficacy of diaminodiphenylsulfone and other drugs in murine Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother., 26, 436, 1984.

    Article  CAS  Google Scholar 

  209. Mills, J., Leoung, G., Medina, I., Hughes, W., Hopewell, P., and Wofsy, C. Dapsone is ineffective therapy for Pneumocystis pneumonia in patients with AIDS. Clin. Res., 34, 101A, 1986.

    Google Scholar 

  210. Medina, I., Mills, J., Leoung, G., et al. Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a controlled trial for trimethoprim-sulfamethoxazole versus trimethoprim-dapsone. N. Engl. J. Med., 323, 776, 1990.

    Article  PubMed  CAS  Google Scholar 

  211. Smego, R. A., Jr., Nagar, S., Maloba, B., and Popara, M. A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia. Arch. Intern. Med., 161, 1529–1533, 2001.

    Article  PubMed  CAS  Google Scholar 

  212. Kay, R. and Dubois, R. E. Clindamycin/primaquine therapy and secondary prophylaxis against Pneumocystis carinii pneumonia in patients with AIDS. South. Med. J., 83, 403, 1990.

    Article  PubMed  CAS  Google Scholar 

  213. Toma, E. Clindamycin/primaquine for treatment of Pneumocystis carinii in AIDS. Eur. J. Clin. Microbiol. Infect. Dis., 10, 210, 1991.

    Article  PubMed  CAS  Google Scholar 

  214. Black, J. R., Feinberg, J., Murphy, R. L., Fass, R. J., Carey, J., and Sattler, F. R. Clindamycin and primaquine as primary treatment for mild and moderately severe Pneumocystis carinii pneumonia in patients with AIDS. Eur. J. Clin. Microbiol. Infect. Dis., 10, 204, 1991.

    Article  PubMed  CAS  Google Scholar 

  215. Ruf, B., Rohde, I., and Pohle, H. D. Efficacy of clindamycin/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia. Eur. J. Clin. Microbiol. Infect. Dis., 10, 207, 1991.

    Article  CAS  Google Scholar 

  216. Panisko, D. M. and Keystone, J. S. Treatment of malaria - 1990. Drugs, 39, 160, 1990.

    Article  PubMed  CAS  Google Scholar 

  217. Smith, N., Blanshard, C., Smith, D., and Gazzard, B. Toxicity of clindamycin and primaquine treatment of AIDS-related Pneumocystic carinii pneumonia. AIDS, 7, 749, 1993.

    Article  PubMed  CAS  Google Scholar 

  218. Zambrano, D. Clindamycin in the treatment of obstetric and gynecologic infections: a review. Clin. Therapeut., 13, 58, 1991.

    CAS  Google Scholar 

  219. Toma, E., Fournier, S., Dumont, M., Bolduc, P., and Deschamps, H. Clindamycin/primaquine versus trimethoprimsulfamethoxazole as primary therapy for Pneumocystis carinii pneumonia in AIDS: a randomized, double-blind pilot trial. Clin. Infect. Dis., 17, 178, 1993.

    Article  PubMed  CAS  Google Scholar 

  220. Noskin, G. A., Murphy, R. L., Black, J. R., and Phair, J. P. Salvage therapy with clindamycin/primaquine for Pneumocystis carinii pneumonia. Clin. Infect. Dis., 14, 183, 1992.

    Article  PubMed  CAS  Google Scholar 

  221. Frenkel, J. K., Good, J. T., and Shultz, J. A. Latent Pneumocystis infection of rats, relapse, and chemotherapy. Lab. Invest., 15, 1559, 1966.

    PubMed  CAS  Google Scholar 

  222. Rifkind, D., Faris, T. D., and Hill, R. B. Jr. Pneumocystis carinii pneumonia: studies on the diagnosis and treatment. Ann. Intern. Med., 65, 943, 1966.

    PubMed  CAS  Google Scholar 

  223. Ruskin, J. and Remington, J. S. The immunocompromised host and infection. 1. Pneumocystis carinii pneumonia. J. Am. Med. Assoc., 202, 96, 1967.

    Article  Google Scholar 

  224. Kirby, H. B., Kenamore, B., and Guckian, J. C. Pneumocystis carinii pneumonia treated with pyrimethamine and sulfadiazine. Ann. Intern. Med., 75, 505, 1971.

    PubMed  CAS  Google Scholar 

  225. Farinas, E. and Quel, J. A. Hypertension and duodenal ulcer associated with Pneumocystis carinii pneumonitis and dysgammaglobulinemia. Ill. J. Med., 139, 138, 1971.

    CAS  Google Scholar 

  226. Whisnant, J. K. and Buckley, R. H. Successful therapy of Pneumocystis carinii pneumonia in infants with x-linked immunodeficiency with hyper-IgM. Natl. Cancer Inst. Monogr., 43, 211, 1976.

    PubMed  CAS  Google Scholar 

  227. Young, R. C. and Devita, V. T. Jr. Treatment of Pneumocystis carinii pneumonia: current status of the regimens of pentamidine isethionate and pyrimethamine-sulfadiazine. Natl. Cancer Inst. Monogr., 43, 193, 1976.

    PubMed  CAS  Google Scholar 

  228. Allegra, C. J., Kovacs, J. A., Drake, J. C., Swan, J. C., Chabner, B. A., and Masur, H. Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent. J. Exp. Med., 165, 926, 1987.

    Article  PubMed  CAS  Google Scholar 

  229. Queener, S. F., Bartlett, M. S., Jay, M. A., Durkin, M. M., and Smith, J. W. Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in rat model of infection. Antimicrob. Agents Chemother., 31, 1323, 1987.

    Article  PubMed  CAS  Google Scholar 

  230. Allegra, C. J., Chabner, B. A., Tuazon, C. U., et al. Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with AIDS. N. Engl. J. Med., 317, 978, 1987.

    Article  PubMed  CAS  Google Scholar 

  231. Amsden, G. W., Kowalsky, S. F., and Morse, G. D. Trimetrexate for Pneumocystis carinii pneumonia in patients with AIDS. Ann. Pharmacother., 26, 218, 1992.

    PubMed  CAS  Google Scholar 

  232. Sattler, F. R., Allegra, C. J., Vergedem, T. D., et al. Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia. J. Infect. Dis., 161, 91, 1990.

    Google Scholar 

  233. Grem, J. L., King, S. A., Costanza, M. E., and Brown, T. D. Hypersensitivity reactions to trimetrexate. Invest. New Drugs, 8, 211, 1990.

    CAS  Google Scholar 

  234. Golden, J. A., Sjoerdsma, A., and Santi, D. A. Pneumocystis carinii pneumonia treated with alphadifluoromethylornithine: a prospective study among patients with the acquired immunodeficiency syndrome. West. J. Med., 141, 613, 1984.

    PubMed  CAS  Google Scholar 

  235. Neibart, E., Sacks, H. S., Hammer, G., and Hirschman, S. Z. Difluoromethylornithine in the treatment of pneumocystis pneumonia. Proc. 8th Intersci. Conf Antimicrob. Agents Chemother., American Society for Microbiology, Washington, D.C., abstract 224, 1986.

    Google Scholar 

  236. Paulson, Y. J. Gilrian, T. M., Boyle, C. T., Sharma, O. P., and Haseltine, P. N. R. Eflornithine treatment of Pneumocystis carinii pneumonia in patients failing other therapy. Proc. 28th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC, abstract 225, 1986.

    Google Scholar 

  237. Smith, D., Davies, S., Nelson, M., Youle, M., Gleeson, J., and Gazzard, B. Pneumocystis carinii pneumonia treated with eflornithine in AIDS patients resistant to conventional therapy. AIDS, 4, 1019, 1990.

    Article  PubMed  CAS  Google Scholar 

  238. Paulson, Y. J., Gilman, T. M., Heseltine, P. N., Sharma, O. P., and Boylen, C. T. Eflornithine treatment of refractory Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Chest, 101, 67, 1992.

    Article  PubMed  CAS  Google Scholar 

  239. Smith, D. E., Davies, S., Smithson, J., Harding, I., and Gazzard, B. G. Eflornithine versus cotrimoxazole in the treatment of Pneumocystis carinii pneumonia in AIDS patients. AIDS, 6, 1489, 1992.

    Article  PubMed  CAS  Google Scholar 

  240. Bozzette, S. A. The use of corticosteroids in Pneumocystis carinii pneumonia. J. Infect. Dis., 162, 1365, 1990.

    Article  PubMed  CAS  Google Scholar 

  241. Walmsley, S., Salit, I. E., and Brunton, J. The possible role of corticosteroid therapy for Pneumocystis carinii in the acquired immune deficiency syndrome (AIDS). J. Acquir. Immune Defic. Syndr., 1, 354, 1988.

    PubMed  CAS  Google Scholar 

  242. Bozzette, S. A., Sattler, F. R., Chiu, J., et al. A controlled trial of early adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. N. Engl. J. Med., 323, 1451, 1990.

    Article  PubMed  CAS  Google Scholar 

  243. MacFadden, D. K., Edelson, J. D., and Rebuck, A. S. Pneumocystis carinii pneumonia in the acquired immune deficiency syndrome: response to inadvertent steroid therapy. Can. Med. Assoc. J., 132, 1161, 1985.

    PubMed  CAS  Google Scholar 

  244. Hurley, P., Weikel, C., Temeles, D., Rosenburg, S., and Pearson, R. Unusual remission of Pneumocystis carinii pneumonia in a patient with the acquired immune deficiency syndrome. Am. J. Med., 82, 645, 1987.

    Article  PubMed  CAS  Google Scholar 

  245. Foltzer, M. A., Hannan, S. E., and Kozak, A. J. Pneumocystis pneumonia: response to corticosteroids. J. Am. Med. Assoc., 253, 979, 1985.

    Article  CAS  Google Scholar 

  246. Rankin, J. A. and Pella, J. A. Radiographic resolution of Pneumocystis carinii pneumonia in response to corticosteroids therapy. Am. Rev. Resp. Dis., 136, 182, 1987.

    CAS  Google Scholar 

  247. El-Sadr, W., Sudhu, G., Diamond, G., et al. High-dose corticosteroids as adjunct therapy in severe Pneumocystis carinii pneumonia. AIDS Res., 2, 349, 1986.

    Article  PubMed  CAS  Google Scholar 

  248. Admundson, D. E., Murray, K. M., Brodine, S., and Oldfield, E. C. High-dose corticosteroid therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. South. Med. J., 82, 711, 1989.

    Article  Google Scholar 

  249. MacFadden, D. K., Hyland, R. H., Inouye, T., Edelson, J. D., Rodriguez, C. H., and Rebuck, S. Corticosteroids as adjunctive therapy in treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet, 1, 1477, 1987.

    Article  PubMed  CAS  Google Scholar 

  250. Mottin, D., Denis, M., Dombret, H., Rossert, J., Mayaud, C. H., and Akoun, G. Role for steroids in treatment of Pneumocystis pneumonia in AIDS. Lancet, 2, 519, 1987.

    Article  PubMed  CAS  Google Scholar 

  251. Montaner, J. S. G. and Ruedy, J. Corticosteroids prevent early deterioration in patients with moderately severe Pneumocystis carinii pneumonia and the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med., 113, 14, 1990.

    PubMed  CAS  Google Scholar 

  252. Gagnon, S., Boota, A. M., Fischl, M. A., Baier, H., Kirksey, O. W., and La Voie, L. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome: a double-blind placebo-controlled trial. N. Engl. J. Med., 323, 1440, 1990.

    Article  Google Scholar 

  253. Nielsen, T. L., Eeftinck Schattenkerk, J. K., Jensen, B.N., et al. Adjunctive corticosteroids therapy for Pneumocystis carinii pneumonia in AIDS: a randomized European multicenter open label study. J. Acquir. Immune Defic. Syndr., 5, 726, 1992.

    PubMed  CAS  Google Scholar 

  254. Jeantils, V., Nguyen, G., Bade, F., and Thomas, M. Adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in AIDS. Therapie, 48, 70, 1993.

    PubMed  CAS  Google Scholar 

  255. Sistek, C. J., Wordell, C. J., and Hauptman, S. P. Adjuvant corticosteroid therapy for Pneumocystis carinii pneumonia in AIDS patients. Ann. Pharmacother., 26, 1127, 1992.

    PubMed  CAS  Google Scholar 

  256. LaRocco, A. Jr., Amundson, D. E., Wallace, M. R., Malone, J. L., and Oldfield, E. C. 3rd. Corticosteroids for Pneumocystis carinii pneumonia with acute respiratory failure: experience with rescue therapy. Chest, 102, 892, 1992.

    Article  PubMed  Google Scholar 

  257. Kaufman, M. B. and DeMuria, D. Corticosteroids in AIDS patients with Pneumocystis carinii pneumonia. Ann. Pharmacother., 26, 932, 1992.

    PubMed  CAS  Google Scholar 

  258. Montaner, J. S., Guillemi, S., Quieffin, J., et al. Oral corticosteroids in patients with mild Pneumocystis carinii pneumonia and the acquired immune deficiency syndrome (AIDS). Tuber. Lung Dis., 74, 173, 1993.

    Article  PubMed  CAS  Google Scholar 

  259. Bentsen, K. D., Nielsen, T. L., Eaftinck Schattenkerk, J. K., Jensen, B. N., and Lundgren, J. D. Serum type III procollagen peptide in patients with Pneumocystis carinii infection: the Copenhagen-Amsterdam PCP-Prednisolone Study Group. Am. Rev. Respir. Dis., 148 (6 Part 1), 1558, 1993.

    Article  PubMed  CAS  Google Scholar 

  260. Huang, Z. B. and Eden, E. Effect of corticosteroids on IL-1 beta and TNF by alveolar macrophages from patients with AIDS and Pneumocystis carinii pneumonia. Chest, 104, 751, 1993.

    Article  PubMed  CAS  Google Scholar 

  261. The National Institute of Health. University of California Expert Panel for Corticosteroids as Adjunctive Therapy for Pneumocystis carinii Pneumonia. Consensus statement on the use of corticosteroids as adjunctive therapy for Pneumocystis pneumonia in the acquired immunodeficiency syndrome. N. Engl. J. Med., 323, 1500, 1990.

    Article  Google Scholar 

  262. Clumeck, N. and Hermans, P. Corticosteroids as adjunctive therapy for Pneumocystis pneumonia in patients with AIDS. N. Engl. J. Med., 324, 1666, 1991.

    Article  Google Scholar 

  263. El-Sadr, W., Milder, J., Capps, L., and Sivapalan, V. Corticosteroids as adjunctive therapy for Pneumocystis pneumonia in patients with AIDS. N. Engl. J. Med., 324, 1667, 1991.

    Google Scholar 

  264. Rahal, J. J. Corticosteroids as adjunctive therapy for Pneumocystis pneumonia in patients with AIDS. N. Engl. J. Med., 324, 1666, 1991.

    Article  Google Scholar 

  265. Hardy, A. M., Wajszczuk, C. P., Suffredini, A. F., Hakala, T. R., and Ho, M. Pneumocystis carinii pneumonia in renal-transplant recipients treated with cyclosporine and steroids. J. Infect. Dis., 149, 143, 1984.

    Article  PubMed  CAS  Google Scholar 

  266. Browne, M. J., Hubbard, S. M., Longo, D. L., et al. Excess prevalence of Pneumocystis carinii pneumonia in patients treated for lymphoma with combination chemotherapy. Ann. Intern. Med., 104, 338, 1986.

    PubMed  CAS  Google Scholar 

  267. Farr, R. W. Pneumocystis carinii pneumania to corticosteroids. South. Med. J., 85, 52, 1992.

    CAS  Google Scholar 

  268. Walmsley, S., Levinton, C., Brunton, J., et al. A multicenter randomized double-blind placebo-controlled trial of adjunctive corticosteroids in the treatment of Pneumocystis carinii pneumonia complicating the acquired immune deficiency syndrome. J. Acquir. Immune Defic. Syndr. Human Retrovirol., 8, 348, 1995.

    CAS  Google Scholar 

  269. Fischl, M. A., Uttamchandani, R. B., Daikos, G. L., et al. An outbreak of tuberculosis caused by multiple-drug-resistant tuberculosis bacilli among patients with HIV infection. Ann. Intern. Med., 117, 177, 1992.

    PubMed  CAS  Google Scholar 

  270. Gill, P. S., Loureiro, C., Bernstein-Singer, M., Rarick, M. U., Sattler, F., and Levine, A. M. Clinical effect of glucocorticoids on Kaposi sarcoma related to the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med., 110, 937, 1989.

    PubMed  CAS  Google Scholar 

  271. Schulhafer, E. P., Grossman, M. E., Fagin, G., and Bell, K. E. Steroid-induced Kaposi’s sarcoma in a patient with pre-AIDS. Am. J. Med., 82, 313, 1987.

    Article  PubMed  CAS  Google Scholar 

  272. Ueda, K., Goto, Y., Yamazaki, S., and Fujisawa, K. Chronic fatal pneumocystosis in nude mice. Jpn. J. Exp. Med., 47, 475, 1977.

    PubMed  CAS  Google Scholar 

  273. Walzer, P. D., Schnelle, V., Armstrong, D., and Rosen, P. P. Nude mouse: a new experimental model for Pneumocystis carinii infection. Science, 197, 177, 1987.

    Article  Google Scholar 

  274. Waltzer, P. D., LaBine, M., Redington, T. J., and Cushion, M. T. Predisposing factors in Pneumocystis carinii pneumonia: effect of tetracycline, protein malnutrition, and corticosteroids on hosts. Infect. Immun., 46, 747, 1984.

    Google Scholar 

  275. Montaner, J. S. G. and Ruedy, J. Corticosteroids prevent early deterioration in patients with moderately severe Pneumocystis carinii pneumonia and the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med., 113, 14, 1990.

    PubMed  CAS  Google Scholar 

  276. Nielsen, T. L., Eeftinck Schattenkerk, J. K., Jensen, B.N., et al. Adjunctive corticosteroids therapy for Pneumocystis carinii pneumonia in AIDS: a randomized European multicenter open label study. J. Acquir. Immune Defic. Syndr., 5, 726, 1992.

    PubMed  CAS  Google Scholar 

  277. Clement, M., Edison, R., Turner, R., et al. Corticosteroid as adjunctive therapy in severe Pneumocystis carinii pneumonia: a prospective, placebo-controlled trial. Am. Rev. Respir. Dis., 139, A250, 1989.

    Google Scholar 

  278. Bozzette, S. A. and Morton, S. C. Reconsidering the use of adjunctive corticosteroids in Pneumocystis pneumonia? J. Acquir. Immune Defic. Syndr. Human Retrovirol., 8, 348, 1995.

    Google Scholar 

  279. Harris, J. E. Improved short-term survival of AIDS patients initially diagnosed with Pneumocystis carinii pneumonia 1984 through 1987. J. Am. Med. Assoc., 263, 397, 1990.

    Google Scholar 

  280. Friedman, Y., Franklin, C., Rackow, E. C., and Weil, M. H. Improved survival in patients with AIDS, Pneumocystis carinii pneumonia, and severe respiratory failure. Chest, 96, 862, 1989.

    Google Scholar 

  281. Marolda, J., Pace, B., Bonforte, R. J., Kotin, N., and Kattan, M. Outcome of mechanical ventilation in children with acquired immunodeficiency syndrome. Pediatr. Pulmonol., 7, 230, 1989.

    Article  PubMed  CAS  Google Scholar 

  282. Bye, M. R., Berstein, L. J., Glaser, J., and Kleid, D. Pneumocystis carinii pneumonia in young children with AIDS. Pediatr. Pulmonol., 9, 251, 1990.

    Article  PubMed  CAS  Google Scholar 

  283. Notterman, D. A., Greenwald, B. M., Di Maio-Hunter, A., Wilkinson, J. D., Krasinski, K., and Borkowsky, W. Outcome after assisted ventilation in children with acquired immunodeficiency syndrome. Crit. Care Med., 18, 18, 1990.

    Article  PubMed  CAS  Google Scholar 

  284. Vernon, D. D., Holzman, B. H., Lewis, P., Scott, G. B., Birriel, J. A., and Scott, M. B. Respiratory failure in children with acquired immunodeficiency syndrome and acquired immunodeficiency syndrome-related complex. Pediatrics, 82, 223, 1988.

    PubMed  CAS  Google Scholar 

  285. Sleasman, J. W., Hemenway, C., Klein, A. S., and Barrett, D. J. Corticosteroids improve survival of children with AIDS and Pneumocystis carinii pneumonia. Am. J. Dis. Child., 147, 30, 1993.

    PubMed  CAS  Google Scholar 

  286. Barone, S. R., Aiuto, L. T., and Krilov, L. R. Increased survival of young infants with Pneumocystis carinii pneumonia and acute respiratory failure with early steroid administration. Clin. Infect. Dis., 19, 212, 1994.

    Article  PubMed  CAS  Google Scholar 

  287. Tilles, S. A. Practical issues in the management of hypersensitivity reactions: sulfonamides. South. Med. J., 94, 817824, 2001.

    Google Scholar 

  288. Waskin, H., Stehr-Green, J. K., Helmick, C. G., and Sattler, F. R. Risk factors for hypoglycemia associated with pentamidine therapy for Pneumocystis pneumonia. J. Am. Med. Assoc., 260, 345, 1988.

    Article  CAS  Google Scholar 

  289. McSharry, R. J., Kirsch, C. M., Jensen, W. A., and Kagawa, F. T. Prophylaxis of aerosolized pentamidine-induced bronchospasm: a symptom-based approach. Am. J. Med. Sci., 306, 20, 1993.

    Article  PubMed  CAS  Google Scholar 

  290. Renzi, P. M., Corbeil, C., Chasse, M., Braidy, J., and Matar, N. Bilateral pneumothoraces hasten mortality in AIDS patients receiving secondary prophylaxis with aerosolized pentamidine: association with a lower Dco prior to receiving aerosolized pentamidine. Chest, 102, 491, 1992.

    Article  PubMed  CAS  Google Scholar 

  291. Comtois, R., Pouliot, J., Gervais, A., Vinet, B., and Lemieux, C. High pentamidine levels associated with hypoglycemia and azotemia in a patient with Pneumocystis carinii pneumonia. Diagn. Microbiol. Infect. Dis., 15, 523, 1992.

    Article  PubMed  CAS  Google Scholar 

  292. Comtois, R., Pouliot, J., Vinet, B., Gervais, A., and Lemieux, C. Higher pentamidine levels in AIDS patients with hypoglycemia and azotemia during treatment of Pneumocystis carinii pneumonia. Am. Rev. Respir. Dis., 146, 740, 1992.

    PubMed  CAS  Google Scholar 

  293. Jones, R. S. Jr., Collier-Brown, C., and Suh, B. Localized cutaneous reaction to intravenous pentamidine. Clin. Infect. Dis., 15, 561, 1992.

    Article  PubMed  Google Scholar 

  294. Klatt, E. C. Pathology of pentamidine-induced pancreatitis. Arch. Pathol. Lab. Med., 116, 162, 1992.

    PubMed  CAS  Google Scholar 

  295. Pouwels, A., Eliaszewicz, M., Larrey, D., et al. Pentamidine-induced acute pancreatitis in a patient with AIDS. J. Clin. Gastroenterol., 12, 457, 1990.

    Article  Google Scholar 

  296. Murphy, R. L., Noskin, G. A., and Ehrenpreis, E. D. Acute pancreatitis associated with aerosolized pentamidine. Am. J. Med., 88 (5N), 53N, 1990.

    Article  PubMed  CAS  Google Scholar 

  297. Balslev, U., Berild, D., and Nielsen, T. L., Cardiac arrest during treatment of Pneumocystis carinii pneumonia with intravenous pentamidine isethionate. Scand. J. Infect. Dis., 24, 111, 1992.

    Article  PubMed  CAS  Google Scholar 

  298. Quadrel, M. A., Atkin, S. H., and Jaker, M. A. Delayed cardiotoxicity during treatment with intravenous pentamidine: two case reports and a review of the literature. Am. Heart J., 123, 1377, 1992.

    Article  PubMed  CAS  Google Scholar 

  299. Balslev, U. and Nielsen, T. L. Adverse effects associated with intravenous pentamidine isethionate as treatment of Pneumocystis carinii pneumonia. Dan. Med. Bull., 39, 366, 1992.

    PubMed  CAS  Google Scholar 

  300. Mani, S., Kocheril, A. G., and Andriole, V. T. Case report: pentamidine and polymorphic ventricular tachycardia revisited. Am. J. Med. Sci., 305, 236, 1993.

    Article  PubMed  CAS  Google Scholar 

  301. Cortese, L. M., Gasser, R. A. Jr., Bjornson, D. C., Dacey, M. J., and Oster, C. N. Prolonged recurrence of pentamidineinduced torsades de pointes. Ann. Pharmacother., 26, 1365, 1992.

    PubMed  CAS  Google Scholar 

  302. Warton, J. M., Demopulos, P. A., and Goldschlager, N. Torsades de pointes during administration of pentamidine isethionate. Am. J. Med., 83, 571, 1987

    Article  Google Scholar 

  303. Harel, Y., Scott, W. A., Szeinberg, A., and Barzilay, Z. Pentamidine-induced torsades de pointes. Pediatr. Infect. Dis. J., 12, 692, 1993.

    PubMed  CAS  Google Scholar 

  304. Green, P. T., Reents, S., Harman, F., and Curtis, A. B. Pentamidine-induced torsades de pointes in a renal transplant recipient with Pneumocystis carinii pneumonia. South. Med. J., 83, 481, 1990.

    Article  PubMed  CAS  Google Scholar 

  305. Mitchell, P., Dodek, P., Lawson, L., Kiess, M., and Russell, J. Torsades de pointes during intravenous pentamidine isethionate therapy. Can. Med. Assoc. J., 140, 173, 1989.

    CAS  Google Scholar 

  306. Hancock, E. W. Possible torsade in a patient with AIDS. Hosp. Pract., 25, 132, 1990.

    CAS  Google Scholar 

  307. Engrav, M. B., Coodley, G., and Magnusson, A. R. Torsades de pointes after inhaled pentamidine. Ann. Emerg. Med., 21, 1404, 1992.

    Google Scholar 

  308. Vukmir, R. B. Torsades de pointes: a review. Am. J. Emerg. Med., 9, 250, 1991.

    Article  PubMed  CAS  Google Scholar 

  309. Stein, K. M., Haronian, H., Mensah, G. A., Acosta, A., Jacobs, J., and Kligfield, P. Ventricular tachycardia and torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Am. J. Cardiol., 66, 888, 1990.

    Article  PubMed  CAS  Google Scholar 

  310. Miller, H. C. Cardiac arrest after intravenous pentamidine in an infant. Pediatr. Infect. Dis. J., 12, 694, 1993.

    Article  PubMed  CAS  Google Scholar 

  311. Tzivoni, D., Keren, A., Cohen, A. M., et al. Magnesium therapy for torsades de pointes. Am. J. Cardiol., 53, 528, 1984.

    Article  PubMed  CAS  Google Scholar 

  312. Sasyniuk, B. I., Valois, M., and Toy, W. Recent advances in understanding the mechanisms of drug-induced torsades de pointes arrhythmias. Am. J. Cardiol., 64, 29J, 1989.

    Google Scholar 

  313. Pais, J. R., Cazorla, C., Novo, E., and Viana, A. Massive haemorrhage from rupture of a pancreatic pseudocyst after pentamidine-associated pancreatitis. Eur. J. Med., 1, 251, 1992.

    PubMed  CAS  Google Scholar 

  314. Mandrell, B. N. and McCormick, J. N. Dapsone-induced methemoglobinemia in pediatric oncology patients: case examples. J. Pediatr. Oncol. Nurs., 18, 224–228, 2001.

    Article  PubMed  CAS  Google Scholar 

  315. DeGowin, R. L., Eppes, B., Powell, R. D., and Carson, P. E. The haemolytic effects of diphenylsulfone (DDS) in normal subjects and in those with glucose-6-phosphate-dehydrogenase deficiency. Bull. WHO, 35, 165, 1966.

    PubMed  CAS  Google Scholar 

  316. Metroka, C. E., Lewis, N. J., and Jacobus, D. P. Desensitization to dapsone in HIV-positive patients. J. Am. Med. Assoc., 267, 512, 1992.

    Article  CAS  Google Scholar 

  317. Freund, Y. R., Dousman, L., Riccio, E. S., Sato, B., MacGregor, J. T., and Mohagheghpour, N. Immunohematotoxicity studies with combinations of dapsone. Int. Immunopharmacol., 1, 2131–2141, 2001.

    Article  PubMed  CAS  Google Scholar 

  318. Kluge, R. M., Spaulding, D. M., and Spain, A. J. Combination of pentamidine and trimethoprim-sulfamethoxazole in the therapy of Pneumocystis carinii pneumonia in rats. Antimicrob. Agents Chemother., 13, 975, 1978.

    Article  CAS  Google Scholar 

  319. Hughes, W. T., McNabb, P. C., Makres, T. D., and Feldman, S. Efficacy of trimethoprim and sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis. Antimicrob. Agents Chemother., 5, 289, 1974.

    Article  PubMed  CAS  Google Scholar 

  320. Hughes, W. T. and Smith, B. L. Efficacy of diaminodiphenylsulfone and other drugs in murine Pneumocystis carinii pneumonitis. Antimicrob. Agents Chemother., 26, 436, 1984.

    Article  PubMed  CAS  Google Scholar 

  321. Frenkel, J. K., Good, J. T., and Shultz, J. A. Latent Pneumocystis infection of rats, relapse and chemotherapy. Lab. Invest., 15, 1559, 1966.

    PubMed  CAS  Google Scholar 

  322. Queener, S. F., Bartlett, M. S., Durkin, M. M., Jay, M. A., and Smith, J. W. Activity of clindamycin with primaquine toward Pneumocystis carinii in vitro and in vivo. Proc. 27th Intersci. Conf. Antimicrob. Agents Chemother., American Society for Microbiology, Washington, DC, abstract 574, 1987.

    Google Scholar 

  323. Hughes, W. T. and Killmar, J. T. Synergistic anti-Pneumocystis carinii effects of erythromycin and sulfisoxazole. J. Acquir. Immune Defic. Syndr., 4, 523, 1991.

    Google Scholar 

  324. Walzer, P. D., Foy, J., Steele, P., and White, M. Synergistic combinations of Ro 11–8958 and other dihydrofolate reductase inhibitors with sulfamethoxazole and dapsone for therapy of experimental pneumocystosis. Antimicrob. Agents Chemother., 37, 1436, 1993.

    Article  PubMed  CAS  Google Scholar 

  325. U.S. Public Health Service Task Force on anti-pneumocystis prophylaxis in patients with human immunodeficiency virus infection: recommendation for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus. J. Acquir. Immune Defic. Syndr., 6, 46, 1993.

    Google Scholar 

  326. Hardy, W. D., Feinberg, J., Finkelstein, D. M., et al. A controlled trial of trimethoprim-sulfamethoxazole or aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome (AIDS clinical trial group protocol 021). N. Engl. J. Med., 327, 1842, 1992.

    Article  PubMed  CAS  Google Scholar 

  327. Arico, M., Molinari, E., Bacchella, L., DeAmici, M., Raiteri, E., and Burgio, G. R. Prospective randomized comparison of toxicity of two prophylactic regimens of cotrimoxazole in leukemic children. Pediatr. Hematol. Oncol., 9, 35, 1992.

    Article  PubMed  CAS  Google Scholar 

  328. Badri, M., Ehrlich, R., Wood, R., and Maartens, G. Initiating co-trimoxazole prophylaxis in HIV-infected patients in Africa: an evaluation of the provisional WHO/UNAIDS recommendation. AIDS, 15, 1143–1148, 2001.

    Article  PubMed  CAS  Google Scholar 

  329. Stearn, B. F. and Polis, M. A. Prophylaxis of opportunistic infections in persons with HIV infection. Cleve. Clin. J. Med., 61, 187, 1994.

    PubMed  CAS  Google Scholar 

  330. Nielsen, T. L., Jensen, B. N., Nelsing, S., et al. Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients: the efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim. Dan. Med. Bull., 40, 503, 1993.

    PubMed  CAS  Google Scholar 

  331. Smulders, Y. M., Spoelstra-de Man, A. M., Slaats, E. H., Weigel, H. M., Stehouwer, C. D., and Jos Frissen P. H. Trimethoprim-sulphamethoxazole as primary Pneumocystis carinii prophylaxis does not increase serum homocysteine levels in HIV-positive subjects. Eur. J. Intern. Med., 12, 363–365, 2001.

    Article  PubMed  CAS  Google Scholar 

  332. Gifford, A. L., McPhee, S. J., and Fordham, D. Preventive care among HIV-positive patients in a general medicine practice. Am. J. Prey. Med., 10, 5, 1994.

    CAS  Google Scholar 

  333. Longini, I. M. Jr., Clark, W. S., and Karon, J. M. Effect of routine use of therapy in slowing the clinical course of human immunodeficiency virus (HIV) infection in a population-based cohort. Am. J. Epidemiol., 137, 1229, 1993.

    PubMed  Google Scholar 

  334. Chaisson, R. E., Keruly, J., Richman, D. D., and Moore, R. D. Pneumocystis prophylaxis and survival in patients with advanced human immunodeficiency virus infection treated with zidovudine. Arch. Intern. Med., 152, 2009, 1992.

    Google Scholar 

  335. Graham, N. M., Zeger, S. L., Park, L. P., et al. The effects on survival of early treatment of human immunodeficiency virus infection. N. Engl. J. Med., 326, 1037, 1992.

    Article  PubMed  CAS  Google Scholar 

  336. Mazur, H. Prophylaxis and therapy for Pneumocystis pneumonia: where are we? Infect. Agents Dis., 1, 270, 1992.

    Google Scholar 

  337. Dworkin, M. S., Williamson, J., Jones, J. L., Kaplan, J. E. Adult and Adolescent Spectrum of HIV Disease Project. Clin. Infect. Dis., 33, 393–398, 2001.

    Article  PubMed  CAS  Google Scholar 

  338. Kovacs, J. A., Gill, V. J., Meshnick, S., and Masur, H. New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia. J. Am. Med. Assoc., 286, 2450–2460, 2001.

    Article  CAS  Google Scholar 

  339. Trikalinos, T. A. and Ioannidis, J. P. Discontinuation of Pneumocystis carinii prophylaxis in patients infected with human immunodeficiency virus: a meta-analysis and decision analysis. Clin. Infect. Dis., 33, 1901–1909, 2001.

    Article  PubMed  CAS  Google Scholar 

  340. Ivez, N. J., Gazzard, B. G., and Esterbrook, P. J. The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART) in a London clinic. J. Infect., 42, 134–139, 2001.

    Article  Google Scholar 

  341. Urschel, S., Schuster, T., Dunsch, D., Wintergerst, U., Hofstetter, R., and Belohradsky, B. H. Discontinuation of primary Pneumocystis carinii prophylaxis after reconstitution of CD4 cell counts in HIV-infected children. AIDS, 15, 1589–1591, 2001.

    Article  PubMed  CAS  Google Scholar 

  342. Koletar, S. L., Heald, A. E., Finkelstein, D., et al. The ACTG 888 Study Team, A prospective study of discontinuing primary and secondary Pneumocystis carinii pneumonia prophylaxis after CD4 cell count increase to 200 x 106 /1. AIDS, 15, 1509–1515, 2001.

    Article  PubMed  CAS  Google Scholar 

  343. Le Moal, G., Breux, J. P., and Roblot, F. Discontinuing prophylaxis against Pneumocystis carinii pneumonia. N. Engl. J. Med., 344, 1639–1641, 2001.

    Article  PubMed  Google Scholar 

  344. U.S. Public Health Service (USPHS) and Infectious Diseases Society of America (IDSA). 1999 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. Infect Dis. Obstet. Gynecol., 8, 5–74, 2000.

    Google Scholar 

  345. Furrer, H., Egger, M., Opravil, M., et al. Discontinuation of primary prophylaxis against Pneumocystis carinii pneumonia in HIV-1-infected adults treated with combination antiretroviral therapy. N. Engl. J. Med., 340, 1301–1306, 1999.

    Article  PubMed  CAS  Google Scholar 

  346. Weverling, G. J., Mocroft, A., Lederberger, B., et al. Discontinuation of Pneumocystis carinii pneumonia prophylaxis after start of highly active antiretroviral therapy in HIV-1 infection. Lancet, 353, 1293–1298, 1999.

    Article  PubMed  CAS  Google Scholar 

  347. Schneider, M. M. E., Borlefs, J. C. C., Stolk, R. P., Jaspers, C. A. J. J., and Hoepelman, A. I. M. Discontinuation of Pneumocystis carinii pneumonia prophylaxis in HIV-1 infected patients treated with highly active retroactive therapy. Lancet, 353, 201–203, 1999.

    Article  PubMed  CAS  Google Scholar 

  348. Dworkin, M., Hanson, D., Jones, J., Kaplan, J., and the Adult/Adolescent Spectrum of HIV Disease Project (ASD). The risk for Pneumocystis carinii pneumonia (PCP) and disseminated non-tuberculous mycobacteriosis (dMb) after an antiretroviral therapy (ART) associated increase in the CD’ T-lymphocyte count. 6th Conf Retroviruse Opport. Infect., abstract no. 692, 1999.

    Google Scholar 

  349. Lopez, J. C., Pena, J. M., Miro, J. M., Podzamczer, D., and the GESIDA 04/98 Study Group. Discontinuation of PCP prophylaxis (PRO) is safe in HIV-infected patients (PTS) with immunological recovery with HAART. Preliminary results of an open, randomized and multicenter clinical trial (GESIDA 04/98). 6th Conf. Retroviruse Opport. Infect., abstract no. LB7, 1999.

    Google Scholar 

  350. Lim, L., Street, A. C., and Lewin, S. R. Pneumocystis carinii pneumonia after cessation of secondary prophylaxis in a patient on highly active antiretroviral therapy with a CD4 cell count greater than 200/mm3. AIDS, 15, 1912–1913, 2001.

    Article  PubMed  CAS  Google Scholar 

  351. Wislez, M., Bergot, E., Antoine, M., et al. Acute respiratory failure following HAART introduction in patients treated for Pneumocystis carinii pneumonia. Am. J. Respir. Crit. Care Med., 164, 847–851, 2001.

    PubMed  CAS  Google Scholar 

  352. Gonzalez-Castillo, J., Blanco, F., Soriano, V., et al. Opportunistic episodes in patients infected with the human immunodeficiency virus during the first 6 months of HAART. Med. Clin. (Barc.), 117, 81–84, 2001.

    CAS  Google Scholar 

  353. Hauser, P. M., Sudre, P., Nahimana, A., Francioli, P. The Study Group, Clin. Infect. Dis., Prophylaxis failure is associated with a specific Pneumocystis carinii genotype. Clin. Infect. Dis., 33, 1080–1082, 2001.

    Article  PubMed  CAS  Google Scholar 

  354. Hamilton, J. D., Hartigan, P. M., Simberkoff, M. S., et al. A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection: results of the Veteran Affairs Cooperative Study. N. Engl. J. Med., 326, 437, 1992.

    Article  PubMed  CAS  Google Scholar 

  355. Hirschel, B. Early zidovudine and survival in HIV infection. N. Engl. J. Med., 327, 814, 1992.

    Article  PubMed  CAS  Google Scholar 

  356. Hartigan, P. M., Hamilton, J. D., and Simberkoff, M. S. Early zidovudine and survival in HIV patients. N. Engl. J. Med., 327, 815, 1992.

    Google Scholar 

  357. Gail, M. H. and Mark, S. D. Early zidovudine and survival in HIV infection. N. Engl. J. Med., 327, 815, 1992.

    PubMed  CAS  Google Scholar 

  358. Asch, S. M., Gifford, A. L., Bozzette, S. A., et al. Underuse of primary Mycobacterium avium complex and Pneumocystis carinii prophylaxis in the United States. J. Acquir. Immune Defic. Syndr., 28, 340–344, 2001.

    PubMed  CAS  Google Scholar 

  359. Castagnola, E., Zarri, D., Caprino, D., Losurdo, G., and Micalizzi, C. Cotrimoxazole prophylaxis of Pneumocystis carinii infection during the treatment of childhood acute lymphoblastic leukemia–beware non compliance in older children and adolescents. Support Care Cancer, 9, 552–553, 2001.

    Article  PubMed  CAS  Google Scholar 

  360. MacGregor, R. R., Morgan, A. S., Graziani, A. L., et al. Efficacy and tolerance of intermittent versus daily cotrimoxazole for PCP prophylaxis in HIV-positive patients. Am. J. Med., 92, 227, 1992.

    Article  PubMed  CAS  Google Scholar 

  361. Leoung, G. S., Stanford, J. F., Giordano, M. F., et al. American Foundation for AIDS Research (amfAR) Community-Based Clinical Trials Network. J. Infect. Dis., 184, 992–997, 2001.

    Article  PubMed  CAS  Google Scholar 

  362. Metroka, C. E., Jacobus, D. P., and Lewis, N. J. Successful chemoprophylaxis for Pneumocystis with dapsone or bactrim. Proc. 5th Int. Conf. AIDS, Montreal, abstract TB04, 1989.

    Google Scholar 

  363. Kemper, C. A., Tucker, R. M., Lang, O. S., et al. Low-dose dapsone prophylaxis of Pneumocystis carinii pneumonia in AIDS and AIDS-related complex. AIDS, 4, 1145, 1990.

    Article  PubMed  CAS  Google Scholar 

  364. Hughes, W. T., Kennedy, W., Dugdale, M., et al. Prevention of Pneumocystis carinii pneumonitis in AIDS patients with weekly dapsone. Lancet, 336, 1066, 1990.

    Article  PubMed  CAS  Google Scholar 

  365. Benedetti-Bardet, C., Guy, C., Boudignat, O., Regnier-Zerbib, A., 011agnier, M. Centres Regionaux de Pharmacovigilance, Adverse effects of disulone: results of the France pharmacovigilance inquiry, Regional centers of Pharmacovigilance. Therapie, 56, 295–299, 2001.

    PubMed  CAS  Google Scholar 

  366. Blum, R. N., Miller, L. A., Gaggini, L. C., and Cohn, D. L. Comparative trial of dapsone versus trimethoprim/sulfamethoxazole for primary prophylaxis of Pneumocystis carinii pneumonia. J. Acquir. Immune Defic. Syndr., 5, 341, 1992.

    PubMed  CAS  Google Scholar 

  367. Podzamczer, D., Santin, M., Jimenez, J., Casanova, A., Bolao, F., and Guidol, G. P. Thrice-weekly cotrimoxazole is better than weekly dapsone-pyrimethamine for the primary prevention of Pneumocystis carinii pneumonia in HIV-infected patients. AIDS, 7, 501, 1993.

    Article  PubMed  CAS  Google Scholar 

  368. Girard, P. M., Landman, R., Gaudebout, C., et al. Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. N. Engl. J. Med., 328, 1514, 1993.

    Article  PubMed  CAS  Google Scholar 

  369. Koppen, S., Grunewald, T., Jautzke, G., Gottschalk, J., Pohle, A. D., and Ruf, B. Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. Clin. Invest., 70, 508, 1992.

    Article  CAS  Google Scholar 

  370. Jensen, B. N., Nielsen, T. L., Backer, V., et al. Aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: a controlled, randomized trial. J. Acquir. Immune Defic. Syndr., 6, 472, 1993.

    PubMed  CAS  Google Scholar 

  371. Ong, E. L., Dunbar, E. M., and Mandai, B. K. Efficacy and effects on pulmonary function tests of weekly 600 mg aerosol pentamidine as prophylaxis against Pneumocystis carinii pneumonia. Infection, 20, 136, 1992.

    Article  PubMed  CAS  Google Scholar 

  372. Tullis, E., Yu, D. G., Rawji, M., Rachlis, A., Hyland, R., and Chan, C. K. The long-term effects of aerosol pentamidine on pulmonary function: the Toronto Aerosolized Pentamidine Study (TAPS) Group. Clin. Invest. Med., 15, 42, 1992.

    PubMed  CAS  Google Scholar 

  373. O’Sullivan, B. P. and Spaulding, R. The use of aerosolized pentamidine for prophylaxis of Pneumocystis carinii pneumonia in children with leukemia. Pediatr. Pulmonol., 18, 228, 1994.

    Article  PubMed  Google Scholar 

  374. Güngör, T., Funk, M., Linde, R., et al. Combined therapy in human immunodeficiency virus-infected children: a 4-year experience. Eur. J. Pediatr., 152, 650, 1993.

    Article  PubMed  Google Scholar 

  375. Rigaud, M., Pollack, H., Leibovitz, E., et al. Efficacy of primary chemoprophylaxis against Pneumocystis carinii pneumonia during the first year of life in infants affected with human immunodeficiency virus type 1. J. Pediatr., 125, 476, 1994.

    Article  PubMed  CAS  Google Scholar 

  376. Mallolas, J., Zamora, L., Gatell, J. M., et al. Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine. AIDS, 7, 59, 1993.

    Article  PubMed  CAS  Google Scholar 

  377. Gutteridge, W. E. 556C80, an antimalarial hydroxynaphthoquinone with broad spectrum: experimental activity against opportunistic parasitic infections of AIDS patients. J. Protozool., 38, 1418, 1991.

    Google Scholar 

  378. Hudson, A. T., Dickins, M., Ginger, C. D., et al. 566C80: a potent broad spectrum anti-infective agent with activity against malaria and opportunistic infections in AIDS patients. Drugs Exptl. Clin. Res., 17, 427, 1991.

    CAS  Google Scholar 

  379. Hughes, W. T., Gray, V. L., Gutteridge, W. E., Latter, V. S., and Pudney, M. Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonits. Antimicrob. Agents Chemother., 34, 225, 1990.

    Article  PubMed  CAS  Google Scholar 

  380. Meyers, B., Borrego, F., and Papanicolaou, G. Pneumocystis carinii pneumonia prophylaxis with atovaquone in trimethoprim-sulfamethoxazole-intolerant orthotopic liver transplant patients: a preliminary study. Liver Transpl., 7, 750–751, 2001.

    Article  PubMed  CAS  Google Scholar 

  381. Schroder, H., Agger, K. E., Rosthoj, S., Carlsen, N. T., and Schmiegelow, K. Antibacterial prophylaxis with trimethoprim-sulfamethoxazole during induction treatment for acute lymphoblastic leukemia. Dan. Med. Bull., 48, 275–277, 2001.

    PubMed  CAS  Google Scholar 

  382. Fisher, R. G., Nageswaran, S., Valentine, M. E., and McKinney, R. E., Jr. Successful prophylaxis against Pneumocystis carinii pneumonia in HIV-infected children using smaller than recommended dosages of trimethoprimsulfamethoxazole. AIDS Patient Care, 15, 263–269, 2001.

    Article  CAS  Google Scholar 

  383. Slivka, A., Wen, P. Y., Shea, W. M., and Loeffler, J. S. Pneumocystis carinii pneumonia during steroid taper in patients with primary brain tumors. Am. J. Med., 94, 216, 1993.

    Article  PubMed  CAS  Google Scholar 

  384. Seymour, J. F., Grigg, A. P., Szer, J., and Fox, R. M. Fludarabine and mitoxanthrone: effective and well-tolerated salvage therapy in relapsed indolent lymphoproliferative disorders. Ann. Oncol., 12, 1455–1460, 2001.

    Article  PubMed  CAS  Google Scholar 

  385. Murphy, J. L., Kano, H. L., Chenaille, P. J., and Makker, S. P. Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis. Pediatr. Nephrol., 7, 444, 1993.

    Article  PubMed  CAS  Google Scholar 

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Georgiev, V.S. (2003). Pneumocystis carinii. In: Opportunistic Infections. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-296-8_35

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