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Handbook of Diagnostic Endocrinology pp 131–155Cite as

Thyroid Nodules and Thyroid Cancer

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Thyroid nodules are a common problem in clinical practice. The majority are benign lesions, predominantly follicular adenomas, although other common causes of benign lesions include cysts, multinodular goiters, colloid goiters, benign Hürthle cell neoplasms, and thyroiditis (1,2).However, some thyroid nodules may, in fact, represent thyroid cancer. The frequency of thyroid cancer in patients presenting with a solitary thyroid nodule has been estimated to be around 5% (2), but the overall prevalence of cancer in all patients with solitary nodules has been estimated to be 0.1–0.2% (3). Because thyroid nodules are so common, but, in general, only malignant nodules or benign ones large enough to cause compressive symptoms require operation, a cost-effective approach to the evaluation of thyroid nodules is important to minimize the number of unnecessary operations.

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Authors
  1. M. Regina Castro MD
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  2. Hossein Gharib MD, FACE, FACP
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Editors and Affiliations

  1. Reproductive Endocrine Unit, Division of Endocrinology, Massachusetts General Hospital, Boston, MA, USA

    Janet E. Hall MD

  2. Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    Lynnette K. Nieman MD

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Castro, M.R., Gharib, H. (2003). Thyroid Nodules and Thyroid Cancer. In: Hall, J.E., Nieman, L.K. (eds) Handbook of Diagnostic Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-293-7_7

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