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Interaction of Copper-Binding Proteins from Enterococcus hirae

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Handbook of Copper Pharmacology and Toxicology

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Abstract

Copper is imported into prokaryotic cells by CPx-type ATPases. CPx-type ATPases have the transmembrane characteristics typical of P-type ATPases involved in the translocation of many ions. A conserved Cys-Pro-X (X = C or H) sequence within the transmembrane channel and a variable number of distinct amino-terminal domains define the CPx classification (1). The cytoplasmic subdomains of the CPx-ATPases have a MxCxxC or M/HxxMDHS/GxM metal-binding site (x = any amino acid). Intracellular copper is utilized in the activation of enzymes, such as cytochrome-c oxidase, superoxide dismutase, and lysyl oxidase. Copper also has the potential to cause cellular damage because of its redox properties. To overcome this dichotomy, the cell regulates copper levels and prevents toxicity with overlapping mechanisms: sequestration, export, and inhibition of entry.

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Author information

Authors and Affiliations

  1. National Research Centre for Environmental Toxicology, University of Queensland, Brisbane, Australia

    Paul A. Cobine, Christopher E. Jones & Wasantha A. Wickramasinghe

  2. Department of Clinical Pharmacology, University of Berne, Berne, Switzerland

    Marc Solioz

  3. Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA, USA

    Charles T. Dameron

Authors
  1. Paul A. Cobine
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  2. Christopher E. Jones
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  3. Wasantha A. Wickramasinghe
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  4. Marc Solioz
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  5. Charles T. Dameron
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Editors and Affiliations

  1. The National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA

    Edward J. Massaro

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© 2002 Springer Science+Business Media New York

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Cobine, P.A., Jones, C.E., Wickramasinghe, W.A., Solioz, M., Dameron, C.T. (2002). Interaction of Copper-Binding Proteins from Enterococcus hirae . In: Massaro, E.J. (eds) Handbook of Copper Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-288-3_9

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  • DOI: https://doi.org/10.1007/978-1-59259-288-3_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-266-7

  • Online ISBN: 978-1-59259-288-3

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