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Copper-Rich Metallothionein Polymers During the Development of Fulminant Hepatitis in LEC Rats

Effect of D-Penicillamine

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Handbook of Copper Pharmacology and Toxicology

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Abstract

The progressive accumulation of copper in hepatocytes of humans and animals may lead to hepatocellular necrosis (1–3). In Wilson’s disease, an inherited disorder of copper metabolism in humans, the excretion of copper into bile is impaired. The phenotype of the disease is caused by a mutation of the ATP7B gene leading to a nonfunctioning gene product, a copper-transporting P-type ATPase (4).

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Authors
  1. Dominik Klein
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  2. Josef Lichtmannegger
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  3. Karl H. Summer
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Editor information

Editors and Affiliations

  1. The National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA

    Edward J. Massaro

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© 2002 Springer Science+Business Media New York

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Klein, D., Lichtmannegger, J., Summer, K.H. (2002). Copper-Rich Metallothionein Polymers During the Development of Fulminant Hepatitis in LEC Rats. In: Massaro, E.J. (eds) Handbook of Copper Pharmacology and Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-288-3_28

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  • DOI: https://doi.org/10.1007/978-1-59259-288-3_28

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-266-7

  • Online ISBN: 978-1-59259-288-3

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