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Case Study of Neonates Born to Mothers Undergoing Buprenorphine Maintenance Treatment

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Buprenorphine Therapy of Opiate Addiction

Part of the book series: Forensic Science and Medicine ((FSM))

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Abstract

In 2000 in France there were over 60,000 ex-drug addicts undergoing high-dose buprenorphine maintenance, to whom must be added those who illicitly use this drug after buying it in the street. It is thus probable that a nonnegligible number of expectant mothers can be found among these buprenorphine users. The literature is poor on the effects of this drug in the fetus (1,2), as well as the effects of the brutal cessation of exposure at birth. The results of animal studies, reported in the introductive chapter (Chapter 9), showed the absence of teratogenic and embryotoxic effects in the animal species in which it was tested.

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References

  1. Boobis AR, Burley D, Margerison Davies D, Davies DS, Harrison PI, Orme ME, Park BK, Goldberg LI. Buprenorphine. In: Therapeutic drugs, vol. 1, Dollery C, ed., Kent, UK, Churchill Livingstone, 1991.

    Google Scholar 

  2. Committee on Drugs of the American Academy of Pediatrics. Neonatal drug withdrawal. Pediatrics 1998; 101: 1079–88.

    Google Scholar 

  3. Marquet P, Chevrel J, Lavignasse P, Merle L, Lachâtre G. Buprenorphine withdrawal syndrome in a newborn. Clin Pharmacol Ther 1997; 62: 569–71.

    Article  PubMed  CAS  Google Scholar 

  4. Jernite M, Viville B, Escande B, Brettes JP, Messer J. Grossesse et buprénorphine. À propos de 24 cas. Arch Pediatr 1999; 6: 1179–89.

    Article  PubMed  CAS  Google Scholar 

  5. Marquet P, Lavignasse P, Chevrel J, Merle L, Lachâtre G. Exposition au Subutex in utero et syndrome de manque du nouveau-né. Toxicorama 1999; 11: 17–24.

    Google Scholar 

  6. Marquet P. High-dose buprenorphine use in pregnant women and consequences for their newborn. In: Proceedings of the 52nd Annual Meeting of the American Academy of Forensic Sciences, Reno, NV, February 21–24, 2000.

    Google Scholar 

  7. Finnegan LP, Weiner SM. Drug withdrawal in the neonate. In: Neonatal intensive care. Merenstein GB, Gardner SL, eds., New York: Mosby Year Book, 1993.

    Google Scholar 

  8. Hoja H, Marquet P, Verneuil B, Lotfi H, Dupuy J-L, Dreyfuss M-F, Lachâtre G. Dosage de buprénorphine et de norbuprénorphine dans l’urine et le sérum par chromatographie liquide couplée à la spectrométrie de masse avec ionisation de type électrospray. Analusis 1996; 24: 104–7.

    CAS  Google Scholar 

  9. Hoja H, Marquet P, Verneuil B, Lotfi H, Dupuy J-L, Lachâtre G. Determination of buprenorphine and norbuprenorphine in whole blood samples by liquid chromatography mass spectrometry. J Anal Toxicol 1997; 21: 160–5.

    PubMed  CAS  Google Scholar 

  10. Kintz P, Cirimele V, Pépin G, Marquet P, Deveaux M, Mura P. Identification et dosage des cannabinoides dans le sang total. Toxicorama 1996; 8 (2): 8–10.

    Google Scholar 

  11. Gaillard Y, Pépin G, Marquet P, Kintz P, Deveaux M, Mura P. Identification et dosage de benzoylecgonine, cocaïne, méthylecgonine-ester, codéine, morphine et 6-acétylmorphine dans le sang total. Toxicorama 1996; 8: 17–22.

    Google Scholar 

  12. Marquet P, Lachâtre G, Kintz P, Pépin G, Deveaux M, Mura P. Identification et dosage des principales drogues amphétaminiques dans le sang total par chromatographie en phase gazeuse couplée à la spectrométrie de masse (CPG-SM). Toxicorama 1996; 8 (2): 23–8.

    Google Scholar 

  13. Cirimele V, Kintz P, Tracqui A, Mangin P. Comparaison des techniques d’extraction de la cocaïne et des opiacés dans les cheveux. Toxicorama 1994; 6 (1): 1–10.

    Google Scholar 

  14. Jarvis M-A-E, Schnoll S-H. Methadone treatment during pregnancy. J Psychoactive Drugs 1994; 26: 155–6.

    Article  PubMed  CAS  Google Scholar 

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© 2002 Humana Press Inc., Totowa, NJ

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Marquet, P., Lavignasse, P., Gaulier, JM., Lachâtre, G. (2002). Case Study of Neonates Born to Mothers Undergoing Buprenorphine Maintenance Treatment. In: Kintz, P., Marquet, P. (eds) Buprenorphine Therapy of Opiate Addiction. Forensic Science and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-282-1_10

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  • DOI: https://doi.org/10.1007/978-1-59259-282-1_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9713-7

  • Online ISBN: 978-1-59259-282-1

  • eBook Packages: Springer Book Archive

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