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Molecular Markers of Bone Turnover

Basic and Analytical Aspects

  • Chapter
Osteoporosis

Part of the book series: Contemporary Endocrinology ((COE))

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Summary

The development of new markers of bone metabolism has greatly enriched the spectrum of serum and urine analytes used in the assessment of skeletal pathologies. Both markers of bone formation and of bone resorption are today widely used in experimental and clinical situations to assess bone turnover, rates of bone loss, future fracture risk and therapeutic efficacy. It should be borne in mind, however, that many of the compounds used as markers of bone turnover may reflect, at least to a certain degree, both bone formation and bone resorption. Furthermore, most of these markers are present in tissues other than bone and may therefore be influenced by nonskeletal processes as well. Thirdly, changes in biochemical markers of bone turnover are usually not disease specific, but reflect overall alterations in skeletal metabolism independent from the underlying cause. Therefore, results of bone marker measurements should always be interpreted against the background of their basic science.

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Authors
  1. Berthold Fohr MD
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  2. Henning W. Woitge MD
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  3. Markus J. Seibel MD
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Editors and Affiliations

  1. Oregon Health & Science University, Portland, OR, USA

    Eric S. Orwoll MD  & Michael Bliziotes MD  & 

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Fohr, B., Woitge, H.W., Seibel, M.J. (2003). Molecular Markers of Bone Turnover. In: Orwoll, E.S., Bliziotes, M. (eds) Osteoporosis. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-278-4_8

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  • DOI: https://doi.org/10.1007/978-1-59259-278-4_8

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