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Osteoporosis pp 375–391Cite as

Androgens and Skeletal Homeostasis

Potential Clinical Implications of Animal Data

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Males deprived of androgen action, due to a lack of functional androgen receptors, have a female and not male phenotype (1,2), indicating that the development of the male phenotype depends on androgen action. The skeletal male phenotype is characterized by stronger bones than in females, primarily because male bones have greater size and not because they contain more mineral for similar size (3,4). It would seem logical, therefore, to assume that androgen action is particularly important for gender differences in bone size. Theoretically, androgen action may affect male skeletal homeostasis in utero, during the neonatal period, as well as before and after puberty. Females, on the other hand, do not secrete sex steroids before early puberty. Therefore, it is unlikely that sex steroids affect skeletal homeostasis before early puberty in the female.

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Authors
  1. Dirk Vanderschueren MD, PhD
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  2. Liesbeth Vandenput PhD
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  3. Johannes V. Swinnen PhD
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  4. Steven Boonen MD, PhD
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  5. Roger Bouillon MD, PhD
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  1. Oregon Health & Science University, Portland, OR, USA

    Eric S. Orwoll MD  & Michael Bliziotes MD  & 

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Vanderschueren, D., Vandenput, L., Swinnen, J.V., Boonen, S., Bouillon, R. (2003). Androgens and Skeletal Homeostasis. In: Orwoll, E.S., Bliziotes, M. (eds) Osteoporosis. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-278-4_18

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