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The Physiology and Cell Biology of Calcium Transport in Relation to the Development of Osteoporosis

  • Chapter
Osteoporosis

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

The vital role that calcium plays as a second messenger in cell signaling processes highlights its importance in a wide range of cellular activities and its fundamental importance to the sustenance of health. In addition, calcium has a specific role in the conduction of action potential along nerves and in the coupling of excitation and contraction in striated and cardiac muscle. These concepts are mentioned in order to acknowledge the importance of calcium in many physiological processes, but the principle focus of this chapter will be on the mechanisms regulating extracellular calcium levels and the ways in which they may affect bone function. In the short term, extracellular calcium balance is far more important to the survival of the individual than total body calcium stores. Since the skeleton contains most of the total body calcium (1–2 kg), it is this compartment that compensates for any reduction in extracellular calcium and it does so at the expense of bone mineral accretion. Consequently, it is the tension between the requirements of separate body compartments that sets the scene for the importance of calcium nutrition in the prevention and treatment of age related osteoporosis.

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Authors
  1. Richard L. Prince MD
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  2. Paul Glendenning PhD
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Editors and Affiliations

  1. Oregon Health & Science University, Portland, OR, USA

    Eric S. Orwoll MD  & Michael Bliziotes MD  & 

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Prince, R.L., Glendenning, P. (2003). The Physiology and Cell Biology of Calcium Transport in Relation to the Development of Osteoporosis. In: Orwoll, E.S., Bliziotes, M. (eds) Osteoporosis. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-278-4_12

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  • DOI: https://doi.org/10.1007/978-1-59259-278-4_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-260-5

  • Online ISBN: 978-1-59259-278-4

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