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Challenging Cases in Endocrinology pp 155–183Cite as

Pheochromocytoma

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

A 51-yr-old woman with neurofibromatosis was seen in the emergency room for symptoms of sinus congestion, productive cough, nausea with emesis, and malaise. She appeared flushed and was found to be profoundly orthostatic by both pulse and blood pressure. Her symptoms, physical exam, and sinus computed tomography (CT) films were all consistent with a diagnosis of sinusitis, and she was therefore admitted for intravenous hydration and antibiotics.

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References

  1. Keiser HR. Pheochromocytoma and related tumors. In: De Groot L, ed. Endocrinology. W.B. Saunders, New York, 1995, pp. 1853–1877.

    Google Scholar 

  2. Espersen T, Dahl-Iversen E. The clinical picture and treatment of tumors of the suprarenal. Acta Chir Scand 1946; 94: 271–290.

    PubMed  CAS  Google Scholar 

  3. Gifford R, Kvale W, Maher F. Clinical features, diagnosis, and treatment of pheochromocytoma: a review of 76 cases. Mayo Clinic Proc 1964; 39: 281–302.

    Google Scholar 

  4. De Courcy JL, De Courcy CB. Pheochromocytomas and the General Practitioner. Barclay Newman, Cincinatti, OH, 1952, p. 163.

    Google Scholar 

  5. Landsberg L, Young J. Catecholamines and the adrenal medulla. In: Foster D, Wilson J, eds. Williams Textbook of Endocrinology, WB Saunders, Philadelphia, PA, 1998, pp. 665–728.

    Google Scholar 

  6. Manger WM, Gifford RW. Clinical and Experimental Pheochromocytoma. Blackwell Science, New York, 1996, p. 570.

    Google Scholar 

  7. Landsberg L. The sympathoadrenal system. In: Bagdade JD, ed. The Yearbook of Endocrinology. Mosby Year Book, St. Louis, MO, 1996, pp. 178, 179.

    Google Scholar 

  8. Aranow H Jr. Pheochromocytoma. In: Bean WB, ed. Monographs in Medicine. Series 1. Williams and Wilkins, Baltimore, MD, 1952, pp. 179–224.

    Google Scholar 

  9. Robinson R. Tumours that Secrete Catecholamines: Their Detection and Clinical Chemistry. John Wiley, Chichester, 1980, p. 65.

    Google Scholar 

  10. Landsberg L, Young JB. Pheochromocytoma. In: Braunwald E, ed. Principles of Internal Medicine. McGraw-Hill, New York, 2001, pp. 2105–2109.

    Google Scholar 

  11. de Leeuw PW, Waltman FL, Birkenhager WH. Noncardiogenic pulmonary edema as the sole manifestation of pheochromocytoma. Hypertension 1986; 8: 810–812.

    Article  PubMed  Google Scholar 

  12. Gan TJ, Miller RF, Webb AR, Russell RC. Phaeochromocytoma presenting as acute hyperamylasaemia and multiple organ failure. Can J Anaesth 1994; 41: 244–247.

    Article  PubMed  CAS  Google Scholar 

  13. Joshi R, Manni A. Pheochromocytoma manifested as noncardiogenic pulmonary edema. South Med J 1993; 86: 826–828.

    Article  PubMed  CAS  Google Scholar 

  14. Okada Y, Suchi M, Takeyama H, Hodgson ME, Kato T, Manabe T. Noncardiogenic pulmonary edema as the chief manifestation of a pheochromocytoma: a case report of MEN 2A with pedigree analysis of the RET proto-oncogene. Tohoku J Exp Med 1999; 188: 177–187.

    Article  PubMed  CAS  Google Scholar 

  15. Lorz W, Cottier C, Imhof E, Gyr N. Multiple organ failure and coma as initial presentation of pheochromocytoma in a patient with multiple endocrine neoplasia (MEN) type II A. Intensive Care Med 1993; 19: 235–238.

    Article  PubMed  CAS  Google Scholar 

  16. van der Kleij FG. Adult respiratory distress syndrome due to pheochromocytoma as the initial presentation of multiple endocrine neoplasia type IIA syndrome [letter]. Am J Med 1999; 107: 401.

    PubMed  Google Scholar 

  17. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 151988. A 26-year-old woman with cardiomyopathy, multiple strokes, and an adrenal mass. N Engl J Med 1988; 318: 970–981.

    Article  Google Scholar 

  18. Berk JL, Hagen JF, Koo R, et al. Pulmonary insufficiency caused by epinephrine. Ann Surg 1973; 178: 423–435.

    Article  PubMed  CAS  Google Scholar 

  19. Newell KA, Prinz RA, Pickleman J, et al. Pheochromocytoma multisystem crisis. A surgical emergency. Arch Surg 1988; 123: 956–959.

    Article  PubMed  CAS  Google Scholar 

  20. Mok CC, Ip TP, So CC. Phaeochromocytoma with adult respiratory distress syndrome mimicking septicaemic shock. Med J Aust 1997; 166: 634–635.

    PubMed  CAS  Google Scholar 

  21. Page LB, Raker JW, Berberick FR. Pheochromocytoma with predominant epinephrine secretion. Am J Med 1969; 47: 648–652.

    Article  PubMed  CAS  Google Scholar 

  22. Fred HL, Allred DP, Garber HE, et al. Pheochromocytoma masquerading as overwhelming infection. Am Heart J 1967; 73: 149–154.

    Article  PubMed  CAS  Google Scholar 

  23. Ford J, Rosenberg F, Chan N. Pheochromocytoma manifesting with shock presents a clinical paradox: a case report. CMAJ 1997; 157: 923–925.

    PubMed  CAS  Google Scholar 

  24. Gordon DL, Atamian SD, Brooks MH, et al. Fever in pheochromocytoma. Arch Intern Med 1992; 152: 1269–1272.

    Article  PubMed  CAS  Google Scholar 

  25. Perrier NA, van Heerden JA, Wilson DJ, Warner MA. Malignant pheochromocytoma masquerading as acute pancreatitis-a rare but potentially lethal occurrence. Mayo Clin Proc 1994; 69: 366–370.

    Article  PubMed  CAS  Google Scholar 

  26. Ross EJ, Griffith DN. The clinical presentation of phaeochromocytoma. Q J Med 1989; 71: 485–496.

    PubMed  CAS  Google Scholar 

  27. Engelman K, Zelis R, Waldmann T, Mason DT, Sjoerdsma AM. Mechanisms of orthostatic hypotension in pheochromocytoma. Circulation 1968; 38 (Suppl 6): 1–72.

    Google Scholar 

  28. Fisher BM, MacPhee GJ, Davies DL, McPherson SG, Brown IL, Goldberg A. A case of watery diarrhoea syndrome due to an adrenal phaeochromocytoma secreting vasoactive intestinal polypeptide with coincidental autoimmune thyroid disease. Acta Endocrinol (Copenh) 1987; 114: 340–344.

    CAS  Google Scholar 

  29. Sackel SG, Manson JE, Harawi SJ, Burakoff R. Watery diarrhea syndrome due to an adrenal pheochromocytoma secreting vasoactive intestinal polypeptide. Dig Dis Sci 1985; 30: 1201–1207.

    Article  PubMed  CAS  Google Scholar 

  30. Wallace MR, Marchuk DA, Andersen LB, et al. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NFl patients. Science 1990; 249: 181–186.

    Article  PubMed  CAS  Google Scholar 

  31. Li Y, O’Connell P, Breidenbach HH, et al. Genomic organization of the neurofibromatosis 1 gene (NF1). Genomics 1995; 25: 9–18.

    Article  PubMed  CAS  Google Scholar 

  32. Gutmann DH, Geist RT, Rose K, Wallin G, Moley JF. Loss of neurofibromatosis type I (NF1) gene expression in pheochromocytomas from patients without NF1. Genes Chromosomes Cancer 1995; 13: 104–109.

    Article  PubMed  CAS  Google Scholar 

  33. Xu W, Mulligan LM, Ponder MA, et al. Loss of NF1 alleles in phaeochromocytomas from patients with type I neurofibromatosis. Genes Chromosomes Cancer 1992; 4: 337–342.

    Article  PubMed  CAS  Google Scholar 

  34. Colman SD, Wallace MR. Neurofibromatosis type 1. Eur J Cancer 1994; 13: 1974–1981.

    Article  Google Scholar 

  35. Kalff V, Shapiro B, Lloyd R, et al. The spectrum of pheochromocytoma in hypertensive patients with neurofibromatosis. Arch Intern Med 1982; 142: 2092–2098.

    Article  PubMed  CAS  Google Scholar 

  36. Gupta KK. Letter: Phaeochromocytoma and myocardial infarction. Lancet 1975; 1: 281–282.

    Article  CAS  Google Scholar 

  37. Plouin PF, Chatellier G, Delahousse M, et al. [Detection, diagnosis and localization of pheochromocytoma. 77 cases in a population of 21,420 hypertensive patients]. Presse Med 1987; 16: 2211–2215.

    PubMed  CAS  Google Scholar 

  38. Miyajima A, Nakashima J, Baba S, Tachibana M, Nakamura K, Murai M. Clinical experience with incidentally discovered pheochromocytoma. J Urol 1997; 157: 1566–1568.

    Article  PubMed  CAS  Google Scholar 

  39. Gifford R, Kvale W, Maher F. Clinical features, diagnosis, and treatment of pheochromocytoma: a review of 76 cases. Mayo Clinic Proceedings 1964; 39: 281–302.

    PubMed  Google Scholar 

  40. Hartley L, Perry-Keene D. Phaeochromocytoma in Queensland-1970–83. Aust N Z J Surg 1985; 55: 471–475.

    Article  PubMed  CAS  Google Scholar 

  41. Kasperlik-Zeluska AA, Roslonowska E, Slowinska-Srzednicka J, et al. Incidentally discovered adrenal mass (incidentaloma): investigation and management of 208 patients. Clin Endocrinol (Oxford) 1997; 46: 29–37.

    Article  CAS  Google Scholar 

  42. Minno A, Bennett W, Kvale W. Pheochromocytoma. A study of 15 cases diagnosed at autopsy. N Engl J Med 1954; 251: 959–965.

    Article  PubMed  CAS  Google Scholar 

  43. Modlin IM, Farndon JR, Shepherd A, et al. Phaeochromocytomas in 72 patients: clinical and diagnostic features, treatment and long term results. Br J Surg 1979; 66: 456–465.

    Article  PubMed  CAS  Google Scholar 

  44. Stenstrom G, Svardsudd K. Pheochromocytoma in Sweden 1958–1981. An analysis of the National Cancer Registry Data. Acta Med Scand 1986; 220: 225–232.

    Article  PubMed  CAS  Google Scholar 

  45. Goldstein RE, O’Neill JA Jr, Holcomb GW III, et al. Clinical experience over 48 years with pheochromocytoma. Ann Surg 1999;229:755–764; discussion 764–766.

    Google Scholar 

  46. Krane NK. Clinically unsuspected pheochromocytomas. Experience at Henry Ford Hospital and a review of the literature. Arch Intern Med 1986; 146: 54–57.

    Article  PubMed  CAS  Google Scholar 

  47. Sutton DM, Hauser R, Kulapongs P, Bachmann F. Intravascular coagulation in abruptio placentae. Am J Obstet Gynecol 1971; 109: 604–614.

    PubMed  CAS  Google Scholar 

  48. Landsberg L, Young J. Catecholamines and the adrenal medulla. In: Foster D, Wilson J, eds. Williams Textbook of Endocrinology, WB Saunders, Philadelphia, PA, 1998, pp. 665–728.

    Google Scholar 

  49. Cross DA, Meyer JS. Postoperative deaths due to unsuspected pheochromocytoma. South Med J 1977; 70: 1320–1321.

    Article  PubMed  CAS  Google Scholar 

  50. Sutton MG, Sheps SG, Lie JT. Prevalence of clinically unsuspected pheochromocytoma. Review of a 50-year autopsy series. Mayo Clin Proc 1981; 56: 354–360.

    PubMed  CAS  Google Scholar 

  51. Barzon L, Scaroni C, Sonino N, et al. Incidentally discovered adrenal tumors: endocrine and scintigraphic correlates. J Clin Endocrinol Metab 1998; 83: 55–62.

    Article  PubMed  CAS  Google Scholar 

  52. Young WF, Jr. Management approaches to adrenal incidentalomas. A view from Rochester, Minnesota. Endocrinol Metab Clin North Am 2000; 29: 159–185.

    Article  PubMed  Google Scholar 

  53. Angeli A, Osella G, Ali A, Terzolo M. Adrenal incidentaloma: an overview of clinical and epidemiological data from the National Italian Study Group. Horm Res 1997; 47: 279–283.

    Article  PubMed  CAS  Google Scholar 

  54. Kloos RT, Gross MD, Francis IR, Korobkin M, Shapiro B. Incidentally discovered adrenal masses. Endocr Rev 1995; 16: 460–484.

    PubMed  CAS  Google Scholar 

  55. Ross NS, Aron DC. Hormonal evaluation of the patient with an incidentally discovered adrenal mass. N Engl J Med 1990; 323: 1401–1405.

    Article  PubMed  CAS  Google Scholar 

  56. Daly PA, Landsberg L. Phaeochromocytoma: diagnosis and management. Baillieres Clin Endocrinol Metab 1992; 6: 143–166.

    Article  PubMed  CAS  Google Scholar 

  57. Belldegrun A, Hussain S, Seltzer SE, Loughlin KR, Gittes RF, Richie JP. Incidentally discovered mass of the adrenal gland. Surg Gynecol Obstet 1986; 163: 203–208.

    PubMed  CAS  Google Scholar 

  58. Hussain S, Belldegrun A, Seltzer SE, Richie JP, Abrams HL. CT diagnosis of adrenal abnormalities in patients with primary non-adrenal malignancies. Eur J Radiol 1986; 6: 127–131.

    PubMed  CAS  Google Scholar 

  59. Doppman JL, Reinig JW, Dwyer AJ, et al. Differentiation of adrenal masses by magnetic resonance imaging. Surgery 1987; 102: 1018–1026.

    PubMed  CAS  Google Scholar 

  60. Boland GW, Lee MJ. Magnetic resonance imaging of the adrenal gland. Crit Rev Diagn Imaging 1995; 36: 115–174.

    PubMed  CAS  Google Scholar 

  61. Reinig JW, Doppman JL, Dwyer AJ, Frank J. MRI of indeterminate adrenal masses. AJR Am J Roentgenol 1986; 147: 493–496.

    Article  PubMed  CAS  Google Scholar 

  62. van Gils A, Falke T, van Erkel A, van de Velde C, Pauwels E. Non-invasive imaging of functioning paragangliomas (including phaeochromocytomas). Frontiers in European Radiology 1990; 7: 1–38.

    Article  Google Scholar 

  63. Maurea S, Cuocolo A, Reynolds JC, et al. Iodine-131-metaiodobenzylguanidine scintigraphy in preoperative and postoperative evaluation of paragangliomas: comparison with CT and MRI. J Nucl Med 1993; 34: 173–179.

    PubMed  CAS  Google Scholar 

  64. van Gils AP, Falke TH, van Erkel AR, et al. MR imaging and MIBG scintigraphy of pheochromocytomas and extraadrenal functioning paragangliomas. Radiographics 1991; 11: 37–57.

    PubMed  Google Scholar 

  65. Candel AG, Gattuso P, Reyes CV, Prinz RA, Castelli MJ. Fine-needle aspiration biopsy of adrenal masses in patients with extraadrenal malignancy. Surgery 1993;114:1132–1136; discussion 1136–1137.

    Google Scholar 

  66. Casola G, Nicolet V, vanSonnenberg E, et al. Unsuspected pheochromocytoma: risk of blood-pressure alterations during percutaneous adrenal biopsy. Radiology 1986; 159: 733–735.

    PubMed  CAS  Google Scholar 

  67. Lambert MA, Hirschowitz L, Russell RC. Fine needle aspiration biopsy: a cautionary tale. Br J Surg 1985; 72: 364.

    Article  PubMed  CAS  Google Scholar 

  68. McCorkell SJ, Niles NL. Fine-needle aspiration of catecholamine-producing adrenal masses: a possibly fatal mistake. AJR Am J Roentgenol 1985; 145: 113–134.

    Article  PubMed  CAS  Google Scholar 

  69. Schenker JG, Chowers I. Pheochromocytoma and pregnancy. Review of 89 cases. Obstet Gynecol Sury 1971; 26: 739–747.

    Article  CAS  Google Scholar 

  70. Stenstrom G, Swolin K. Pheochromocytoma in pregnancy. Experience of treatment with phenoxybenzamine in three patients. Acta Obstet Gynecol Scand 1985; 64: 357–361.

    Article  PubMed  CAS  Google Scholar 

  71. Harper MA, Murnaghan GA, Kennedy L, Hadden DR, Atkinson AB. Phaeochromocytoma in pregnancy. Five cases and a review of the literature. Br J Obstet Gynaecol 1989; 96: 594–606.

    Article  PubMed  CAS  Google Scholar 

  72. Keely E. Endocrine causes of hypertension in pregnancy-when to start looking for zebras. Semin Perinatol 1998; 22: 471–484.

    Article  PubMed  CAS  Google Scholar 

  73. Manger WM, Gifford RW. Clinical and Experimental Pheochromocytoma. Blackwell Science, New York, 1996, p. 570.

    Google Scholar 

  74. Wilber JF, Turtle JR, Crane NA. Inhibition of insulin secretion by a phaeochromocytoma. Lancet 1966; 2: 733.

    Article  PubMed  CAS  Google Scholar 

  75. Isles CG, Johnson JK. Phaeochromocytoma and diabetes mellitus: further evidence that alpha 2 receptors inhibit insulin release in man. Clin Endocrinol (Oxford) 1983; 18: 37–41.

    Article  CAS  Google Scholar 

  76. Rosen SG, Clutter WE, Shah SD, Miller JP, Bier DM, Cryer PE. Direct alpha-adrenergic stimulation of hepatic glucose production in human subjects. Am J Physiol 1983; 245: E616 - E626.

    PubMed  CAS  Google Scholar 

  77. Spergel G, Bleicher SJ, Ertel NH. Carbohydrate and fat metabolism in patients with pheochromocytoma. N Engl J Med 1968; 278: 803–809.

    Article  PubMed  CAS  Google Scholar 

  78. Stenstrom G, Sjostrom L, Smith U. Diabetes mellitus in phaeochromocytoma. Fasting blood glucose levels before and after surgery in 60 patients with phaeochromocytoma. Acta Endocrinol (Copenh) 1984; 106: 511–515.

    CAS  Google Scholar 

  79. Balestrieri PG, Spandrio S, Romanelli G, Giustina G. Diabetes mellitus as presenting feature in extra-adrenal pheochromocytoma: report of a case. Acta Diabetol Lat 1990; 27: 261–265.

    Article  PubMed  CAS  Google Scholar 

  80. Schenker JG, Granat M. Phaeochromocytoma and pregnancy-an updated appraisal. Aust N Z J Obstet Gynaecol 1982; 22: 1–10.

    Article  PubMed  CAS  Google Scholar 

  81. Zuspan FP. Catecholamines. Their role in pregnancy and the development of pregnancy-induced hypertension. J Reprod Med 1979; 23: 143–150.

    PubMed  CAS  Google Scholar 

  82. Easterling TR, Carlson K, Benedetti TJ, Mancuso JJ. Hemodynamics associated with the diagnosis and treatment of pheochromocytoma in pregnancy. Am J Perinatol 1992; 9: 464–466.

    Article  PubMed  CAS  Google Scholar 

  83. el-Minawi MF, Paulino E, Cuesta M, Ceballos J. Pheochromocytoma masquerading as pre-eclamptic toxemia. Current concepts of diagnosis and treatment. Am J Obstet Gynecol 1971; 109: 389–395.

    PubMed  CAS  Google Scholar 

  84. Hendee AE, Martin RD, Waters WC. Hypertension in pregnancy: toxemia or pheochromocytoma? Am J Obstet Gynecol 1969; 105: 64–72.

    PubMed  CAS  Google Scholar 

  85. Zuspan FP. Urinary excretion of epinephrine and norepinephrine during pregnancy. J Clin Endocrinol Metab 1970; 30: 357–360.

    Article  PubMed  CAS  Google Scholar 

  86. Goodall M, Diddle AW. Epinephrine and norepinephrine in pregnancy. A comparative study of the adrenal gland and catechol output in different species of animals and man. Am J Obstet Gynecol 1971; 111: 896–904.

    PubMed  CAS  Google Scholar 

  87. Kimura N, Miura Y, Nagatsu I, Nagura H. Catecholamine synthesizing enzymes in 70 cases of functioning and non-functioning phaeochromocytoma and extra-adrenal paraganglioma. Virchows Arch A Pathol Anat Histopathol 1992; 421: 25–32.

    Article  PubMed  CAS  Google Scholar 

  88. Evinger MJ, Towle AC, Park DH, Lee P, Joh TH. Glucocorticoids stimulate transcription of the rat phenylethanolamine N-methyltransferase (PNMT) gene in vivo and in vitro. Cell Mol Neurobiol 1992; 12: 193–215.

    Article  PubMed  CAS  Google Scholar 

  89. Funahashi H, Imai T, Tanaka Y, et al. Discrepancy between PNMT presence and relative lack of adrenaline production in extra-adrenal pheochromocytoma. J Surg Oncol 1994; 57: 196–200.

    Article  PubMed  CAS  Google Scholar 

  90. Greenberg M, Moawad AH, Wieties BM, et al. Extraadrenal pheochromocytoma: detection during pregnancy using MR imaging. Radiology 1986; 161: 475–476.

    PubMed  CAS  Google Scholar 

  91. Udelsman R, Fishman EK. Radiology of the adrenal. Endocrinol Metab Clin North Am 2000; 29: 27–42.

    Article  PubMed  CAS  Google Scholar 

  92. Breuer H. The metabolism of the natural estrogens. Vitamins and Hormones 1962; 20: 285.

    Article  CAS  Google Scholar 

  93. Dahia PL, Hayashida CY, Strunz C, Abelin N, Toledo SP. Low cord blood levels of catecholamine from a newborn of a pheochromocytoma patient. Eur J Endocrinol 1994; 130: 217–219.

    Article  PubMed  CAS  Google Scholar 

  94. Landsberg L. Pheochromocytoma complicating pregnancy [comment]. Eur J Endocrinol 1994; 130: 215216.

    Google Scholar 

  95. Landsberg L, Young J. Catecholamines and the Adrenal Medulla. In: Foster D, Wilson J, eds. Williams Textbook of Endocrinology, WB Saunders, Philadelphia, PA, 1998, pp. 665–728.

    Google Scholar 

  96. Bravo EL. Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. Endocr Rev 1994; 15: 356–368.

    PubMed  CAS  Google Scholar 

  97. Freier DT, Thompson NW. Pheochromocytoma and pregnancy: the epitome of high risk. Surgery 1993; 114: 1148–1152.

    PubMed  CAS  Google Scholar 

  98. Fudge TL, McKinnon WM, Geary WL. Current surgical management of pheochromocytoma during pregnancy. Arch Surg 1980; 115: 1224–1225.

    Article  PubMed  CAS  Google Scholar 

  99. Burgess GE. Alpha blockade and surgical intervention of pheochromocytoma in pregnancy. Obstet Gynecol 1979; 53: 266–270.

    PubMed  Google Scholar 

  100. Griffith MI, Felts JH, James FM, Meyers RT, Shealy GM, Woodruff LF Jr. Successful control of pheochromocytoma in pregnancy. JAMA1974; 229: 437–439.

    Google Scholar 

  101. Lyons CW, Colmorgen GH. Medical management of pheochromocytoma in pregnancy. Obstet Gynecol 1988; 72: 450–451.

    PubMed  CAS  Google Scholar 

  102. Simanis J, Amerson JR, Hendee AE, Anton AH. Unresectable pheochromocytoma in pregnancy. Pharmacology and biochemistry. Am J Med 1972; 53: 381–385.

    Article  PubMed  CAS  Google Scholar 

  103. Venuto R, Burstein P, Schneider R. Pheochromocytoma: antepartum diagnosis and management with tumor resection in the puerperium. Am J Obstet Gynecol 1984; 150: 431–432.

    PubMed  CAS  Google Scholar 

  104. Sukenik S, Biale Y, Ben-Aderet N, Khodadadi J, Levi D, Stern J. Successful control of pheochromocytoma in pregnancy. Case report. Eur J Obstet Gynecol Reprod Biol 1979; 9: 249–251.

    Article  PubMed  CAS  Google Scholar 

  105. Oliver MD, Brownjohn AM, Vinall PS. Medical management of phaeochromocytoma in pregnancy. Aust N Z J Obstet Gynaecol 1990; 30: 268–271.

    Article  PubMed  CAS  Google Scholar 

  106. Mastboom JL. [Treatment of pheochromocytoma during pregnancy]. Geburtshilfe Frauenheilkd 1966; 26: 568–571.

    PubMed  CAS  Google Scholar 

  107. Chukwuemeka AC, Paton AM, Gebbie DA, Ayim EN, Dhall DP. Phaeochromocytoma in pregnancy. East Afr Med J 1974; 51: 496–499.

    PubMed  CAS  Google Scholar 

  108. Batts JA Jr, Tchilinguirian NG, Passmore J. Pheochromocytoma in pregnancy: a case report and review of the pathophysiology. Am J Obstet Gynecol 1974; 118: 576–577.

    PubMed  Google Scholar 

  109. Pestelek B, Kapor M. Pheochromocytoma and abruptio placentae. Am J Obstet Gynecol 1963; 85: 538–540.

    PubMed  CAS  Google Scholar 

  110. Pritchard JA, Mason R, Corley M, Pritchard S. Genesis of severe placental abruption. Am J Obstet Gynecol 1970; 108: 22–27.

    PubMed  CAS  Google Scholar 

  111. Naeye RL, Harkness WL, Utts J. Abruptio placentae and perinatal death: a prospective study. Am J Obstet Gynecol 1977; 128: 740–746.

    PubMed  CAS  Google Scholar 

  112. Kramer MS, Usher RH, Pollack R, Boyd M, Usher S. Etiologic determinants of abruptio placentae. Obstet Gynecol 1997; 89: 221–226.

    Article  PubMed  CAS  Google Scholar 

  113. Ananth CV, Smulian JC, Vintzileos AM. Incidence of placental abruption in relation to cigarette smoking and hypertensive disorders during pregnancy: a meta-analysis of observational studies. Obstet Gynecol 1999; 93: 622–628.

    Article  PubMed  CAS  Google Scholar 

  114. Sutton DM, Hauser R, Kulapongs P, Bachmann F. Intravascular coagulation in abruptio placentae. Am J Obstet Gynecol 1971; 109: 604–614.

    PubMed  CAS  Google Scholar 

  115. Sipple J. The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 1961; 31: 163–166.

    Article  Google Scholar 

  116. Gage] R. Multiple Endocrine Neoplasia. In: Foster D, Wilson J, eds. Williams Textbook of Endocrinology. WB Saunders, Philadelphia, PA, 1998, pp. 1627–1649.

    Google Scholar 

  117. Gagel RF, Tashjian AH Jr, Cummings T, et al. The clinical outcome of prospective screening for multiple endocrine neoplasia type 2a. An 18-year experience. N Engl J Med 1988; 318: 478–484.

    Article  PubMed  CAS  Google Scholar 

  118. Vasen HF, Nieuwenhuijzen Kruseman AC, Berke] H, et al. Multiple endocrine neoplasia syndrome type 2: the value of screening and central registration. A study of 15 kindreds in The Netherlands. Am J Med 1987; 83: 847–852.

    Article  PubMed  CAS  Google Scholar 

  119. Howe JR, Norton JA, Wells SA Jr. Prevalence of pheochromocytoma and hyperparathyroidism in multiple endocrine neoplasia type 2A: results of long-term follow-up. Surgery 1993; 114: 1070–1077.

    PubMed  CAS  Google Scholar 

  120. Carney JA, Sizemore GW, Sheps SG. Adrenal medullary disease in multiple endocrine neoplasia, type 2: pheochromocytoma and its precursors. Am J Clin Pathol 1976; 66: 279–290.

    PubMed  CAS  Google Scholar 

  121. Keiser HR, Beaven MA, Doppman J, Wells S Jr, Buja LM. Sipple’s syndrome: medullary thyroid carcinoma, pheochromocytoma, and parathyroid disease. Studies in a large family. NIH conference. Ann Intern Med 1973; 78: 561–579.

    PubMed  CAS  Google Scholar 

  122. Modigliani E, Vasen HM, Raue K, et al. Pheochromocytoma in multiple endocrine neoplasia type 2: European study. The Euromen Study Group. J Int Med 1995; 238: 363–367.

    Article  CAS  Google Scholar 

  123. Pomares FJ, Canas R, Rodriguez JM, Hernandez AM, Parrilla P, TebarFJ. Differences between sporadic and multiple endocrine neoplasia type 2A phaeochromocytoma. Clin Endocrinol (Oxf) 1998; 48: 195200.

    Google Scholar 

  124. Calmettes C, Rosenberg-Gourgin M, Caron J, Feingold N. Pheochromocytoma: a frequent indicator for MEN 2. Henry Ford Hosp Med J 1992; 40: 276–277.

    PubMed  CAS  Google Scholar 

  125. Santoro M, Melillo RM, Carlomagno F, et al. Molecular biology of the MEN2 gene. J Intern Med 1998; 243: 505–508.

    Article  PubMed  CAS  Google Scholar 

  126. Eng C. RET proto-oncogene in the development of human cancer. J Clin Oncol 1999; 17: 380–393.

    PubMed  CAS  Google Scholar 

  127. Gage] RF, Cote GJ, Martins Bugalho MJ, et al. Clinical use of molecular information in the management of multiple endocrine neoplasia type 2A. J Intern Med 1995; 238: 333–341.

    Article  PubMed  CAS  Google Scholar 

  128. Lips CJ, Landsvater RM, Hoppener JW, et al. Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A [see comments]. N Engl J Med 1994; 331: 828–835.

    Article  PubMed  CAS  Google Scholar 

  129. Mulligan LM, Eng C, Healey CS, et al. Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC. Nat Genet 1994; 6: 70–74.

    Article  PubMed  CAS  Google Scholar 

  130. Eng C, Clayton D, Schuffenecker I, et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA1996; 276: 1575–1579.

    Google Scholar 

  131. Frank-Raue K, Hoppner W, Frilling A, et al. Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group. J Clin Endocrinol Metab 1996; 81: 1780–1783.

    Article  PubMed  CAS  Google Scholar 

  132. Frank-Raue K, Kratt T, Hoppner W, Buhr H, Ziegler R, Raue F. Diagnosis and management of pheochromocytomas in patients with multiple endocrine neoplasia type 2-relevance of specific mutations in the RET proto-oncogene. Eur J Endocrinol 1996; 135: 222–225.

    Article  PubMed  CAS  Google Scholar 

  133. Schuffenecker I, Billaud M, Calender A, et al. RET proto-oncogene mutations in French MEN 2A and FMTC families. Hum Mol Genet 1994; 3: 1939–1943.

    Article  PubMed  CAS  Google Scholar 

  134. Ponder BA. The phenotypes associated with ret mutations in the multiple endocrine neoplasia type 2 syndrome. Cancer Res 1999;59:1736s-1741s; discussion 1742s.

    Google Scholar 

  135. Vistelle R, Grulet H, Gibold C, et al. High permanent plasma adrenaline levels: a marker of adrenal medullary disease in medullary thyroid carcinoma. Clin Endocrinol (Oxf) 1991; 34: 133–138.

    Article  CAS  Google Scholar 

  136. Hamilton BP, Landsberg L, Levine RJ. Measurement of urinary epinephrine in screening for pheochromocytoma in multiple endocrine neoplasia type II. Am J Med 1978; 65: 1027–1032.

    Article  PubMed  CAS  Google Scholar 

  137. Eisenhofer G, Lenders JW, Linehan WM, Walther MM, Goldstein DS, Keiser HR. Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. N Engl J Med 1999; 340: 1872–1879.

    Article  PubMed  CAS  Google Scholar 

  138. Beldjord C, Desclaux-Arramond F, Raffin-Sanson M, et al. The RET protooncogene in sporadic pheochromocytomas: frequent MEN 2-like mutations and new molecular defects [see comments]. J Clin Endocrinol Metab 1995; 80: 2063–2068.

    Article  PubMed  CAS  Google Scholar 

  139. Zedenius J, Wallin G, Hamberger B, Nordenskjold M, Weber G, Larsson C. Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s. Hum Mol Genet 1994; 3: 1259–1262.

    Article  PubMed  CAS  Google Scholar 

  140. Brauch H, Hoeppner W, Jahnig H, et al. Sporadic pheochromocytomas are rarely associated with germ-line mutations in the vhl tumor suppressor gene or the ret protooncogene. J Clin Endocrinol Metab 1997; 82: 4101–4104.

    Article  PubMed  CAS  Google Scholar 

  141. Bar M, Friedman E, Jakobovitz O, et al. Sporadic phaeochromocytomas are rarely associated with germ-line mutations in the von Hippel-Lindau and RET genes. Clin Endocrinol (Oxf) 1997; 47: 707–712.

    Article  CAS  Google Scholar 

  142. Eng C, Crossey PA, Mulligan LM, et al. Mutations in the RET proto-oncogene and the von HippelLindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas. J Med Genet 1995; 32: 934–937.

    Article  PubMed  CAS  Google Scholar 

  143. Lindor NM, Honchel R, Khosla S, Thibodeau SN. Mutations in the RET protooncogene in sporadic pheochromocytomas. J Clin Endocrinol Metab 1995; 80: 627–629.

    Article  PubMed  CAS  Google Scholar 

  144. Hofstra RM, Stelwagen T, Stulp RP, et al. Extensive mutation scanning of RET in sporadic medullary thyroid carcinoma and of RET and VHL in sporadic pheochromocytoma reveals involvement of these genes in only a minority of cases. J Clin Endocrinol Metab 1996; 81: 2881–2884.

    Article  PubMed  CAS  Google Scholar 

  145. Lairmore TC, Ball DW, Baylin SB, Wells SA Jr. Management of pheochromocytomas in patients with multiple endocrine neoplasia type 2 syndromes. Ann Surg 1993;217:595–601; discussion 601–603.

    Google Scholar 

  146. Jansson S, Tisell LE, Fjalling M, Lindberg S, Jacobsson L, Zachrisson BF. Early diagnosis of and surgical strategy for adrenal medullary disease in MEN II gene carriers. Surgery 1988; 103: 11–18.

    PubMed  CAS  Google Scholar 

  147. Lips KJ, Van der Sluys Veer J, Struyvenberg A, et al. Bilateral occurrence of pheochromocytoma in patients with the multiple endocrine neoplasia syndrome type 2A (Sipple’ s syndrome). Am J Med 1981; 70: 1051–1060.

    Article  PubMed  CAS  Google Scholar 

  148. Tibblin S, Dymling JF, Ingemansson S, Telenius-Berg M. Unilateral versus bilateral adrenalectomy in multiple endocrine neoplasia IIA. World J Surg 1983; 7: 201–208.

    Article  PubMed  CAS  Google Scholar 

  149. de Graaf JS, Dullaart RP, Zwierstra RP. Complications after bilateral adrenalectomy for phaeochromocytoma in multiple endocrine neoplasia type 2—a plea to conserve adrenal function. Eur J Surg 1999; 165: 843–846.

    Article  PubMed  Google Scholar 

  150. Jadoul M, Leo JR, Berends MJ, et al. Pheochromocytoma-induced hypertensive encephalopathy revealing MEN-IIa syndrome in a 13-year old boy. Implications for screening procedures and surgery. Horm Metab Res Suppl 1989; 21: 46–49.

    PubMed  CAS  Google Scholar 

  151. Casanova S, Rosenberg-Bourgin M, Farkas D, et al. Phaeochromocytoma in multiple endocrine neoplasia type 2 A: survey of 100 cases. Clin Endocrinol (Oxf) 1993; 38: 531–537.

    Article  CAS  Google Scholar 

  152. Engelman K. Principles in the diagnosis of pheochromocytoma. Bull N Y Acad Med 1969; 45: 851–858.

    PubMed  CAS  Google Scholar 

  153. Landsberg L, Young J. Catecholamines and the adrenal medulla. In: Foster D, Wilson J, eds. Williams Textbook of Endocrinology, WB Saunders, Philadelphia, PA, 1998, pp. 665–728.

    Google Scholar 

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Authors
  1. Mary P. Gillam MD
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  2. Lewis Landsberg MD
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Editors and Affiliations

  1. Center for Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, IL, USA

    Mark E. Molitch MD

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Gillam, M.P., Landsberg, L. (2002). Pheochromocytoma. In: Molitch, M.E. (eds) Challenging Cases in Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-277-7_9

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  • DOI: https://doi.org/10.1007/978-1-59259-277-7_9

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