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Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

A 38-yr-old woman was referred to our institution for evaluation of hypoglycemia. Over the past year, she had experienced frequent episodes of hunger, leg tremors, and dizziness occurring up to eight times per day. These symptoms resolved within 15–45 min following the ingestion of food. Symptoms occurred at any time of the day and appeared to be unrelated to food ingestion. Snacks eaten every 2 h did not improve or help prevent symptoms. She had not experienced confusion or loss of consciousness. Self-monitored blood glucose levels up to 15 times per day during symptoms were associated with “low” glucose levels, the lowest value being 52 mg/dL. Her highest blood glucose value was approximately 200 mg/dL, taken shortly after a meal, but she could not recall whether she had symptoms at that time. There was no record of venipuncture plasma glucose values while symptomatic.

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References

  1. American Diabetes Association. Consensus statement on self-monitoring of blood glucose. Diabetes Care 1987; 10: 95–99.

    Google Scholar 

  2. Service FJ. Hypoglycemic disorders. N Engl J Med 1995; 32: 1 144–1152.

    Google Scholar 

  3. O’Brien T, O’Brien PC, Service FJ. Insulin surrogates in insulinoma. J Clin Endocrinol Metab 1993; 77: 449–451.

    Google Scholar 

  4. Service FJ. Diagnostic approach to adults with hypoglycemic disorders. In: Endocrinology and Metabolism Clinics of North America 1999;28(3):519–532.

    Google Scholar 

  5. Towler DA, Havlin CE, Craft S, et al. Mechanism of awareness of hypoglycemia. Diabetes 1993;42:1791— 1798.

    Google Scholar 

  6. Service FJ, Dale AJD, Elveback LR, et al. Insulinoma: clinical and diagnostic features of 60 consecutive cases. Mayo Clinic Proc 1976; 51: 417–429.

    CAS  Google Scholar 

  7. Merimee TJ, Fineberg S. Homeostasis during fasting. Hormone substrate differences between men and women. J Clin Endocrinol Metab 1973; 37: 698–702.

    Google Scholar 

  8. Connor H, Scarpello JHB. An insulinoma with reactive hypoglycaemia. Postgrad Med J 1979; 55: 735738.

    Google Scholar 

  9. Lev-Ran A, Andresen RW. The diagnosis of postprandial hypoglycemia. Diabetes 1981; 30: 996–999.

    Article  PubMed  CAS  Google Scholar 

  10. Doppman JL, Miller DL, Chang R, et al. Insulinoma localization with selective intraarterial injection of calcium. Radiology 1991; 178: 327–241. (Erratum, Radiology 1993;187:880).

    Google Scholar 

  11. Service FJ, Natt N, Thompson GB, et al. Noninsulinoma pancreatogenous hypoglycemia. A novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in kir6.2 and SUR 1 genes. J Clin Endocrinol Metab 1999; 84: 1582–1589.

    Article  PubMed  CAS  Google Scholar 

  12. Thompson GB, Service FJ, Natt N, et al. Noninsulinoma pancreatogenous hypoglycemia syndrome: an update in 10 surgically treated patients. Surgery 2000; 128: 937–944.

    Article  PubMed  CAS  Google Scholar 

  13. Karnauchow PN. Nesidioblastosis in adults without insular hyperfunction. Am J Clin Path 1981; 78: 51 1513.

    Google Scholar 

  14. Dunne MJ, Kane C, Shepherd RM, et al. Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor. N Engl J Med 1997; 336: 703–706.

    Article  PubMed  CAS  Google Scholar 

  15. Klonoff DC, Barrett MJ, Nolte MS, et al. Hypoglycemia following inadvertent and factitious sulphonylurea overdosages. Diabetes Care 1995; 18: 563–567.

    Article  PubMed  CAS  Google Scholar 

  16. Roy M, Roy A. Factitious hypoglycemia: an 11-year follow-up. Psychosomatics 1995; 36: 64–65.

    Article  PubMed  CAS  Google Scholar 

  17. Thompson GB, Service F1, van Heerden JA, et al. Reoperative insulinomas, 1927 to 1992: an institutional experience. Surgery 1993; 114: 1196–206.

    PubMed  CAS  Google Scholar 

  18. Stark DD, Moss AA, Goldberg HI, et al. Computed tomography and nuclear magnetic resonance imaging of pancreatic islet cell tumors. Surgery 1993; 94: 1024–1027.

    Google Scholar 

  19. Fedorak IJ, Ko TC, Gordon D. Localization of islet cell tumors of the pancreas: a review of current techniques. Surgery 1993; 113: 242–249.

    PubMed  CAS  Google Scholar 

  20. Jian-Cun Huai, Zhengzhou Henan, Wel Zhang, et al. Localization and surgical treatment of pancreatic insulinomas guided by intraoperative ultrasound. Am J Surgery 1997; 175: 18–21

    Article  Google Scholar 

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© 2002 Springer Science+Business Media New York

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Natt, N., Service, F.J. (2002). Hypoglycemia. In: Molitch, M.E. (eds) Challenging Cases in Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-277-7_18

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  • DOI: https://doi.org/10.1007/978-1-59259-277-7_18

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-249-0

  • Online ISBN: 978-1-59259-277-7

  • eBook Packages: Springer Book Archive

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