Abstract
A 62-yr-old woman presented in the outpatient clinic with a serum calcium of 10.6 mg/dL (normal, 8.9–10.1 mg/dL) and phosphate of 2.8 mg/dL (normal, 2.5–4.5 mg/dL). Her serum total alkaline phosphatase was 160 U/L (normal, 108–282 U/L), and serum creatinine 0.8 mg/dL (normal, 0.6–0.9 mg/dL). Her whole-molecule parathyroid hormone (PTH) by immunochemiluminometric assay (ICMA) was increased at 5.5 pmol/L (normal 1.05.2 pmol/L). Her 24-h urine calcium was 260 mg (normal, 20–275 mg), with 24-h urine creatinine 1100 mg. The calculated calcium to creatinine clearance ratio (24-h urine calcium × serum creatinine/24-h urine creatinine × serum total calcium) was 0.018, consistent with a diagnosis of primary hyperparathyroidism.
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Clarke, B.L., Khosla, S. (2002). Hypercalcemia and Hyperparathyroidism. In: Molitch, M.E. (eds) Challenging Cases in Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-277-7_10
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DOI: https://doi.org/10.1007/978-1-59259-277-7_10
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