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Pituitary Tumors

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

A 27-yr-old woman initially presented to the emergency room in 1988 at age 16 with increasing headaches and decreased visual acuity and was found to have a visual field defect. She also had primary amenorrhea. A computed tomography (CT) scan showed a 2 × 3-cm suprasellar mass and she was admitted to the neurosurgery service. She was operated on for what was thought then to be a craniopharyngioma. Her examination at that time showed a modestly obese young girl of normal height with Tanner Stage IV breast and pubic hair development. Preoperative laboratory results that were not available at the time of the surgery showed a serum PRL of 1270 ng/mL, a cortisol of 6.6 µg/dL, a T4 of 4.8 µg/dL, a growth hormone (GH) of 1.4 ng/mL, a luteinizing hormone (LH) of 3.8 mIU/mL, and a follicle-stimulating hormone (FSH) of 17.4 mIU/mL. Postoperatively, her PRL was 415 ng/mL and she was referred to the endocrine service where testing showed panhypopituitarism. A postoperative MRI showed little change in the tumor size. She was begun on 1-thyroxine, prednisone, and bromocriptine.

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References

  1. Partington MD, Davis DH, Laws ER Jr, Scheithauer BW. Pituitary adenomas in childhood and adolescence. Results of transsphenoidal surgery. J Neurosurg 1994; 80: 209–216.

    Article  PubMed  CAS  Google Scholar 

  2. Mindermann T, Wilson CB. Pediatric pituitary adenomas. Neurosurgery 1995; 36: 259–269.

    Article  PubMed  CAS  Google Scholar 

  3. Artese R, D’ Osvaldo DH, Molocznik I, et al. Pituitary tumors in adolescent patients. Neurol Res 1998; 20: 415–417.

    PubMed  CAS  Google Scholar 

  4. Colao AM, Loche S, Cappa M, et al. Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up. J Clin Endocrinol Metab 1998; 83: 2777–2780.

    Article  PubMed  CAS  Google Scholar 

  5. Molitch ME. Prolactinoma. In: Melmed S, ed. The Pituitary. 2nd ed. Blackwell Scientific, Boston, MA, in press.

    Google Scholar 

  6. Laws ER Jr, Thapar K. Pituitary surgery. Endocrinol Metab Clin North Am 1999; 28: 119–131.

    Article  PubMed  Google Scholar 

  7. Ciric I, Ragin A, Baumgartner C, Pierce D. Complications of transsphenoidal surgery: results of a national survey, review of the literature, and personal experience. Neurosurgery 1997; 40: 225–236.

    Article  PubMed  CAS  Google Scholar 

  8. Vermesh M, Fossum GT, Kletzky OA. Vaginal bromocriptine: pharmacology and effect on serum prolactin in normal women. Obstet Gynecol 1988; 72: 693–698.

    PubMed  CAS  Google Scholar 

  9. Katz E, Schran HF, Adashi EY. Successful treatment of a prolactin-producing pituitary macroadenoma with intravaginal bromocriptine mesylate: a novel approach to intolerance of oral therapy. Obstet Gynecol 1989; 73: 517–520.

    PubMed  CAS  Google Scholar 

  10. Freda PU, Andreadis CI, Khandji G, et al. Long-term treatment of prolactin-secreting macroadenomas with pergolide. J Clin Endocrinol Metab 2000; 85: 8–13.

    Article  PubMed  CAS  Google Scholar 

  11. DiSalle E, Ornati G, Giudici D. A comparison of the in vivo and in vitro duration of prolactin lowering effect in rats of FCE 21336, pergolide and bromocriptine. J Endocrinol Invest 1984; 7 (Suppl l): 32.

    Google Scholar 

  12. Strolin BM, Doster P, Barone D, Efthymiopoulos C, Peretti G, Roncucci R. In vivo interaction of CAB with rat brain dopamine receptors labelled with 3H-N-n-propylinorapomorphine. Eur J Pharmacol 1990; 187: 399–408.

    Article  Google Scholar 

  13. Andreotti AC, Pianezzola E, Persiani S, et al. Pharmacokinetics, pharmacodynamics, and tolerability of cabergoline, a prolactin-lowering drug after administration of increasing oral doses (0.5, 1.0, and 1.5 milligrams) in healthy male volunteers. J Clin Endocrinol Metab 1995; 80: 841.

    Article  PubMed  CAS  Google Scholar 

  14. Webster J, Piscitelli G, Polli A, Ferrari CI, Ismail I, Scanlon MF for the Cabergoline Comparative Study Group. N Engl J Med 1994; 331: 904–909.

    Article  PubMed  CAS  Google Scholar 

  15. Motta T, Colombo N, de Vincentiis S, D’Alberton A, Marchini M. Vaginal cabergoline in the treatment of hyperprolactinemic patients intolerant to oral dopaminergics. Fertil Steril 1996; 65: 440–442.

    PubMed  CAS  Google Scholar 

  16. Biller BMK, Molitch ME, Vance ML, Cannistraro KB, Davis KR, Simons JA, SchoefelderJR, Klibanski A. Treatment of prolactin-secreting macroadenomas with the once-weekly dopamine agonist cabergoline. J Clin Endocrinol Metab 1996; 81: 2338–2343.

    Article  PubMed  CAS  Google Scholar 

  17. Delgrange E, Maiter D, Donckier J. Effects of the dopamine agonist cabergoline in patients with prolactinoma intolerant or resistant to bromocriptine. Eur J Endocrinol 1996; 134: 454–456.

    Article  PubMed  CAS  Google Scholar 

  18. Colao A, DeSarno A, Landi ML, et al. Long-term and low-dose treatment with cabergoline induces macroprolactinoma shrinkage. J Clin Endocrinol Metab 1997; 82: 3574–3579.

    Article  PubMed  CAS  Google Scholar 

  19. Ferrari CI, Abs R, Bevan JS, et al. Treatment of macroprolactinoma with cabergoline: a study of 85 patients. Clin Endocrinol 1997; 46: 409–413.

    Article  CAS  Google Scholar 

  20. Colao A, DiSarno A, Sarnacchiaro S, Ferone D, DiRenzo G, Annunziato L, Merola B, Lombardi G. Prolactinomas resistant to standard dopamine-agonists respond to chronic cabergoline treatment. J Clin Endocrinol Metab 1997; 82: 876–883.

    Article  PubMed  CAS  Google Scholar 

  21. Inzelberg R, Nisipeanu P, Rabey JM, et al. Double-blind comparison of cabergoline and bromocriptine in Parkinson’s disease patients with motor fluctuations. Neurology 1996; 47: 785–788.

    Article  PubMed  CAS  Google Scholar 

  22. Shull JD, Gorski J. Regulation of prolactin gene transcription in vivo: Interactions between estrogen, pimozide, and ergocryptine. Molec Pharmacol 1989; 37: 215–221.

    Google Scholar 

  23. Molitch ME. Management of prolactinomas during pregnancy. J Reprod Med 1999; 44 (Suppl): 1121–1126.

    PubMed  CAS  Google Scholar 

  24. Corenblum B, Donovan L. The safety of physiological estrogen plus progestin replacement therapy and with oral contraceptive therapy in women with pathological hyperprolactinemia. Fertil Steril 1993; 59: 671–673.

    PubMed  CAS  Google Scholar 

  25. Testa G, Vegetti W, Motta T, et al. Two-year treatment with oral contraceptives in hyperprolactinemic patients. Contraception 1998; 58: 69–73.

    Article  PubMed  CAS  Google Scholar 

  26. Melmed S, Ho K, Klibanski A, et al. Recent advances in pathogenesis, diagnosis and management of acromegaly. J Clin Endocrinol Metab 1995; 80: 3395–3402.

    Article  PubMed  CAS  Google Scholar 

  27. Ezzat S, Forster MJ, Berchtold P, et al. Acromegaly: clinical and biochemical features in 500 patients. Medicine 1994; 73: 233–240.

    Article  PubMed  CAS  Google Scholar 

  28. Molitch ME. Clinical manifestations of acromegaly. Endocrinol Metab Clin North Am 1992; 21: 597–614.

    PubMed  CAS  Google Scholar 

  29. Chang-DeMoranville BM, Jackson IMD. Diagnosis and endocrine testing in acromegaly. Endocrinol Metab Clin North Am 1992; 21: 649–668.

    PubMed  CAS  Google Scholar 

  30. Klein I, Levey GS. Unusual manifestations of hypothyroidism. Arch Intern Med 1984; 144: 123–128.

    Article  PubMed  CAS  Google Scholar 

  31. Samaan NA. Hypoglycemia secondary to endocrine deficiencies. Endocrinol Metab Clin North Am 1989; 18: 145–154.

    PubMed  CAS  Google Scholar 

  32. Faglia G, Arosio M, Bazzoni M. Ectopic acromegaly. Endocrinol Metab Clin North Am 1992; 21: 575–596.

    PubMed  CAS  Google Scholar 

  33. Beuschlein F, Strasburger CJ, Siegerstetter V, et al. Acromegaly caused by secretion of growth hormone by a non-Hodgkin’s lymphoma. N Engl J Med 2000; 342: 1871–1876.

    Article  PubMed  CAS  Google Scholar 

  34. Flier JS, Moller DE, Moses AC, et al. Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab 1993; 76: 1533–1541.

    Article  PubMed  CAS  Google Scholar 

  35. Krook AS, Kumar I, Laing AJM, et al. Molecular scanning of the insulin receptor gene in syndromes of insulin resistance. Diabetes 1994; 43: 357–368.

    Article  PubMed  CAS  Google Scholar 

  36. Kumar S, Durrington PM, O’Rahilly S, et al. Severe insulin resistance, diabetes mellitus, hypertriglyceridemia and pseudoacromegaly. J Clin Endocrinol Metab 1996; 81: 3465–3468.

    Article  PubMed  CAS  Google Scholar 

  37. Dib K, Whitehead JP, Humphreys Pi, et al. Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance. J Clin Invest 1998; 101: 1111–1120.

    Article  PubMed  CAS  Google Scholar 

  38. Chapman IM, Hartman ML, Straume M, et al. Enhanced sensitivity growth hormone (GH) chemiluminescence assay reveals lower post-glucose nadir GH concentrations in men than women. J Clin Endocrinol Metab 1994; 78: 1312–1319.

    Article  PubMed  CAS  Google Scholar 

  39. Dimaraki EV, Jaffe CA, DeMott-Frieberg R, et al. Micromegaly: Active acromegaly with normal GH levels. Implications for diagnostic and follow-up criteria. Abstract P3–658, 81st Ann Meet Endocrine Soc, San Diego, CA, 1999.

    Google Scholar 

  40. Bartalena L. Recent achievements in studies on thyroid hormone binding proteins. Endocr Rev 1990; 11: 47–63.

    Article  PubMed  CAS  Google Scholar 

  41. Klee GG, Hay ID. Biochemical testing of thyroid function. Endocrinol Metab Clin North Am 1997; 26: 763–775.

    Article  PubMed  CAS  Google Scholar 

  42. McDermott MT, Ridgway CE. Central hyperthyroidism. Endocrinol Metab Clin North Am 1998; 27: 187–203.

    Article  PubMed  CAS  Google Scholar 

  43. Refetoff S. Clinical and genetic aspects of resistance to thyroid hormone. The Endocrinologist 1992; 2: 261–271.

    Article  Google Scholar 

  44. Wynne AG, Gharib H, Scheithauer BW, et al. Hyperthyrodism due to inappropriate secretion of thyrotropin in 10 patients. Am J Med 1992: 92: 15–24.

    Article  PubMed  CAS  Google Scholar 

  45. Beck-Peccoz P, Brucker-Davis F, Persani L, et al. Thyrotropin-secreting pituitary tumors. Endocr Rev 1996; 17: 610–633.

    PubMed  CAS  Google Scholar 

  46. Yovos JG, Falko JM, O’Dorisio TM, et al. Thyrotoxicosis and a thyrotropin secreting pituitary tumor causing unilateral exophtalmos. J Clin Endocrinol Metab 1981; 53: 338–342.

    Article  PubMed  CAS  Google Scholar 

  47. Ober KP. Thyrotoxic periodic paralysis in the United States. Report of 7 cases and review of the literature. Medicine 1992; 71: 109–120.

    Article  PubMed  CAS  Google Scholar 

  48. Nellen H, Mercado M, Villanueva S, et al. Thyrotoxic periodic paralysis in Mexican Mestizo patients: a clinical, biochemical and HLA-serological study. Arch Med Res 1999; 30: 74–76.

    Article  PubMed  CAS  Google Scholar 

  49. Kiso Y, Yoshida K, Kaise K. A case of thyrotropin (TSH) secreting tumor complicated by periodic paralysis. Jpn J Med 1990; 29: 399–404.

    Article  PubMed  CAS  Google Scholar 

  50. McCutcheon IE, Weintraub BD, Oldfield EH. Surgical treatment of thyrotropin secreting pituitary adenomas. J Neurosurg 1990; 73: 674–683.

    Article  PubMed  CAS  Google Scholar 

  51. Smallridge RC. Thyrotropin-secreting pituitary tumors. Endocrinol Metab Clin North Am 1987; 16: 765–792.

    PubMed  CAS  Google Scholar 

  52. Shomali ME, Katznelson L. Medical therapy for gonadotroph and thyrotroph tumors. Endocrinol Metab Clin North Am 1999; 28: 223–240.

    Article  PubMed  CAS  Google Scholar 

  53. Comi RJ, Gesundheit N, Murray L, et al. Response of thyrotropin-secreting pituitary adenomas to a long-acting somatostatin analogue. N Engl J Med 1987; 317: 12–17.

    Article  PubMed  CAS  Google Scholar 

  54. Black PM, Hsu DW, Klibanski A. Hormone production in clinically non-functioning pituitary adenomas. J Neurosurg 1987; 66: 244–250.

    Article  PubMed  CAS  Google Scholar 

  55. Heshmati HM, Turpin G, Kujas M. The immunocytochemical heterogeneity of silent pituitary adenomas. Acta Endocrinol 1988; 118: 533–537.

    PubMed  CAS  Google Scholar 

  56. Zuniga S, Mendoza V, Felix-Espinosa I, et al. A plurihormonal TSH-secreting pituitary microadenoma: report of a case with an atypical clinical presentation and transient response to bromocriptine therapy. Endocr Pathol 1997; 8: 81–86.

    Article  PubMed  Google Scholar 

  57. Molitch ME. Pituitary incidentalomas. Endocrinol Metab Clin North Am 1997; 26: 725–740.

    Article  PubMed  CAS  Google Scholar 

  58. Chong B W, Kucharczyk AW, Singer W, et al. Pituitary gland MR: a comparative study of healthy volunteers and patients with microadenomas. Am J Neuroradiol 1994; 15: 675–679.

    PubMed  CAS  Google Scholar 

  59. Hall WA, Luciano MG, Doppman JL, et al. Pituitary magnetic resonance imaging in normal human volunteers: occult adenomas in the general population. Ann Intern Med 1994; 120: 817–820.

    PubMed  CAS  Google Scholar 

  60. Reincke M, Allolio B, Saeger W, et al. The `incidentaloma’ of the pituitary gland. Is neurosurgery required? JAMA 1990; 263: 2772–2776.

    Article  PubMed  CAS  Google Scholar 

  61. Donovan LE, Corenblum B. The natural history of the pituitary incidentaloma. Arch Intern Med 1995; 153: 181–183.

    Article  Google Scholar 

  62. Nishizawa S, Ohta S, Yokoyama T, Uemura K. Therapeutic strategy for incidentally found pituitary tumors (“pituitary incidentalomas”). Neurosurgery 1998; 43: 1344–1350.

    PubMed  CAS  Google Scholar 

  63. Feldkamp J, Santen R, Harms E, et al. Incidentally discovered pituitary lesions: high frequency of macroadenomas and hormone-secreting adenomas-results of a prospective study. Clin Endocrinol 1999; 51: 109–113.

    Article  CAS  Google Scholar 

  64. Eguchi K, Migita K, Arita K, et al. Natural course and management of incidentally found pituitary lesions. Program of the 6th Int Pituitary Congress, Long Beach, CA, 1999, p. 99.

    Google Scholar 

  65. Arafah AM. Reversible hypopituitarism in patients with large nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 1986; 62: 1173–1179.

    Article  PubMed  CAS  Google Scholar 

  66. Ebersold MJ, Quast LM, Laws ER, Scheithauer B, Randall RV. Long-term results in transsphenoidal removal of nonfunctioning pituitary adenomas. J Neurosurg 1986; 64: 713–719.

    Article  PubMed  CAS  Google Scholar 

  67. Comtois R, Beauregard H, Somma M, et al. The clinical and endocrine outcome to transsphenoidal microsurgery of nonsecreting pituitary adenomas. Cancer 1991; 68: 860–866.

    Article  PubMed  CAS  Google Scholar 

  68. Tominaga A, Uozumi T, Arita K, et al. Anterior pituitary function in patients with nonfunctioning pituitary adenoma: results of longitudinal follow-up. Endocrine J 1995; 42: 421–427.

    Article  CAS  Google Scholar 

  69. King JT Jr, Justice AC, Aron DC. Management of incidental pituitary microadenomas: a cost-effectiveness analysis. J Clin Endocrinol Metab 1997; 82: 3625–3632.

    Article  PubMed  CAS  Google Scholar 

  70. Lillehei KO, Kirschman DL, Kleinschmidt-DeMasters B, Ridgway EC. Reassessment of the role of radiation therapy in the treatment of endocrine-inactive pituitary macroadenomas.Neurosurgery 1998; 43: 432–439.

    CAS  Google Scholar 

  71. Webb SM, Rigla M, Wagner A, Oliver B, Bartumeus F. Recovery of hypopituitarism after neurosurgical treatment of pituitary adenomas. J Clin Endocrinol Metab 1999; 84: 3696–3700.

    Article  PubMed  CAS  Google Scholar 

  72. Molitch ME, Reichlin S. Hypothalamic hyperprolactinemia: neuroendocrine regulation of prolactin secretion in patients with lesions of the hypothalamus and pituitary stalk. In: Macleod RM, Thonier MO, Scapagnini U, eds. Prolactin. Basic and Clinical Correlates. Proc IVth Int Congr Prolactin. Liviana, Padova, Italy, 1985, pp. 709–719.

    Google Scholar 

  73. Bevan JS, Burke CW, Esiri MM, Adams CBT. Misinterpretation of prolactin levels leading to management errors in patients with sellar enlargement. Am J Med 1987; 82: 29–32.

    Article  PubMed  CAS  Google Scholar 

  74. Kruse A, Astrup J, Gyldensted C, Cold GE. Hyperprolactinaemia in patients with pituitary adenomas. The pituitary stalk compression syndrome. Br J Neurosurg 1995; 9: 453–457.

    Article  PubMed  CAS  Google Scholar 

  75. St-Jean E, Blain F, Comtois R. High prolactin levels may be missed by immunoradiometric assay in patients with macroprolactinomas. Clin Endocrinol 1996; 44: 305–309.

    Article  CAS  Google Scholar 

  76. Barkan A, Chandler WF. Giant pituitary prolactinoma with falsely low serum prolactin: the pitfall of the “high-dose hook effect”: case report. Neurosurgery 1998: 9; 13–15.

    Google Scholar 

  77. Ciric I, Ragin A, Baumgartner C, Pierce D. Complications of transsphenoidal surgery: results of a national survey, review of the literature and personal experience. Neurosurgery 197; 40: 225–237.

    Google Scholar 

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Mercado, M., Molitch, M.E. (2002). Pituitary Tumors. In: Molitch, M.E. (eds) Challenging Cases in Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-277-7_1

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  • DOI: https://doi.org/10.1007/978-1-59259-277-7_1

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