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Molecular and Cellular Basis of Inflammation pp 289–307Cite as

Molecular Biology of Autoimmune Arthritis

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Part of the book series: Current Inflammation Research ((CIRES))

Abstract

Rheumatoid arthritis is one of the most common autoimmune diseases of humans. Although this crippling, debilitating disease is generally characterized as a localized inflammation of synovial tissue that often results in the loss of joint function, systemic effects of the autoimmune disease are also clearly present. Despite advances in the understanding of the pathological processes involved in rheumatoid arthritis, its etiology remains a mystery. In this chapter, the authors will consider the current hypotheses put forth to explain the molecular basis for susceptibility to rheumatoid arthritis, and discuss recent information concerning the role of cytokines in modulating the inflammatory response and mechanisms of induction of matrix metalloproteinase (MMP) gene expression, and the role of these enzymes in tissue degradation. In addition, they will examine the role animal models of experimental autoimmune arthritis have played in advancing the authors’ understanding of the autoimmunity of rheumatoid arthritis and its associated pathology. Finally, they will highlight the significance of ongoing studies toward the development of promising therapies for the treatment of rheumatoid arthritis.

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Authors
  1. Edward F. Rosloniec
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  2. Leslie R. Ballou
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  3. Rajendra Raghow
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  4. Karen A. Hasty
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  5. Andrew H. Kang
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Editors and Affiliations

  1. Department of Anesthesia, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Charles N. Serhan

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Peter A. Ward

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Rosloniec, E.F., Ballou, L.R., Raghow, R., Hasty, K.A., Kang, A.H. (1999). Molecular Biology of Autoimmune Arthritis. In: Serhan, C.N., Ward, P.A. (eds) Molecular and Cellular Basis of Inflammation. Current Inflammation Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-253-1_14

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