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Adenosine and Its Receptors During Inflammation

  • Chapter
Molecular and Cellular Basis of Inflammation

Part of the book series: Current Inflammation Research ((CIRES))

Abstract

The number of endogenous mediators of inflammation is large and growing, but the list of endogenous inhibitors of inflammation has remained relatively small. Most investigators are familiar with glucocorticoids, and there is an increasing appreciation of lipid mediators, select cytokines, and endogenous cytokine inhibitors as anti-inflammatory mediators. Adenosine, a purine nucleoside, is another agent that has received increasing interest as an endogenous anti-inflammatory agent. In this chapter the author will discuss the generation of adenosine at inflamed sites, the cell surface receptors for adenosine, which, when occupied, affect inflammatory cell function and the functional effects of adenosine on the various inflammatory cells and the inflammatory process. Finally, the author will discuss the potential pharmacologic uses of adenosine as an anti-inflammatory agent.

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Authors
  1. Bruce N. Cronstein
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Editors and Affiliations

  1. Department of Anesthesia, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Charles N. Serhan

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Peter A. Ward

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Cronstein, B.N. (1999). Adenosine and Its Receptors During Inflammation. In: Serhan, C.N., Ward, P.A. (eds) Molecular and Cellular Basis of Inflammation. Current Inflammation Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-253-1_12

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  • DOI: https://doi.org/10.1007/978-1-59259-253-1_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-089-2

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