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Pathobiology of Neutrophil Interactions with Polarized Columnar Epithelia

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Molecular and Cellular Basis of Inflammation

Part of the book series: Current Inflammation Research ((CIRES))

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Abstract

Luminal spaces in the alimentary tract, airway, and renal tubule are defined by encasing monolayers of polarized columnar epithelia. Such epithelial monolayers, which rest on a basement membrane above connective tissue through which course lymphatics and the microvasculature, serve to protect the underlying tissues from these varied, but harsh, luminal environments. This separating attribute of epithelial monolayers, termed “barrier function,” is maintained in part by apical circumferential tight junctions that adjoin neighboring epithelial cells in gasketlike fashion, thus preventing free diffusion of noxious hydrophilic solutes between neighboring cells (1). While maintaining barrier function, epithelial cells must simultaneously vectorially transport a host of molecules including nutrients, ions, immunoglobulin, and water across the monolayer. Tissue related variations in these transport functions of columnar epithelia largely define the specific functions assigned to various organs including the intestine, stomach, kidney, and so on. Similarly, such epithelia synthesize and secrete products including mucins and, in some areas such as the airway, have surface structures (cilia) that assist in clearing the surface of potential threats.

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Authors
  1. James L. Madara
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Editors and Affiliations

  1. Department of Anesthesia, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Charles N. Serhan

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    Peter A. Ward

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© 1999 Springer Science+Business Media New York

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Madara, J.L. (1999). Pathobiology of Neutrophil Interactions with Polarized Columnar Epithelia. In: Serhan, C.N., Ward, P.A. (eds) Molecular and Cellular Basis of Inflammation. Current Inflammation Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-253-1_11

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  • DOI: https://doi.org/10.1007/978-1-59259-253-1_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-089-2

  • Online ISBN: 978-1-59259-253-1

  • eBook Packages: Springer Book Archive

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