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Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis

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Modern Therapeutics in Rheumatic Diseases

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Abstract

The pathogenesis of rheumatoid arthritis (RA) is complex. It includes the production of many proinflammatory and destructive mediators by inflamed synovial tissue (1). A widely accepted paradigm suggests that tumor necrosis factor a (TNF-a) and interleukin-1 (IL-1) are critical pathogenetic cytokines (2). The rationale supporting anti-TNFoc therapy and the clinical efficacy and safety of two therapeutic compounds, used either in monotherapeutic strategies (3,4) or in combination with methotrexate (MTX) (5,6) , have been described. This chapter will highlight the role of IL-1(3 in the pathogenesis of both synovial inflammation and cartilage matrix degradation in RA. In addition, the effects of inhibiting IL-β-mediated pathogenetic pathways by targeted therapeutic intervention in experimental arthritis models and in RA will be examined.

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  1. Barry Bresnihan
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Editors and Affiliations

  1. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    George C. Tsokos

  2. Walter Reed Army Institute of Research, Silver Spring, MD, USA

    George C. Tsokos

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Bresnihan, B. (2002). Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis. In: Tsokos, G.C. (eds) Modern Therapeutics in Rheumatic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-239-5_7

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  • DOI: https://doi.org/10.1007/978-1-59259-239-5_7

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