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The Role of Nephrectomy and Metastasectomy for Advanced Renal Cell Carcinoma

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Book cover Renal Cell Carcinoma

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Renal cell carcinoma (RCC) accounts for over 85% of all solid kidney tumors and is the third most common genitourinary malignancy after carcinoma of the prostate and bladder. Approximately 28–33,000 new cases of RCC are diagnosed per year in the United States, accounting for 3% of all adult malignancies, with an incidence roughly equal to that of all forms of leukemia combined (1). Over one third of patients with RCC will ultimately die of their disease. Despite the increase in incidentally discovered tumors due to the widespread use of noninvasive radiographic imaging techniques (2–4), 25–30% of patients present with locally advanced or metastatic disease (5). Delay in diagnosis may result from the ability of space occupying lesions of the retroperitoneum to become quite large before causing local symptoms. Additionally, manifestations of RCC are protean and may give rise to a constellation of nonspecific symptoms causing delayed detectionordiscovery ofthe lesionwhile pursuing otherdiagnoses. Finally, microscopic hematuria may go undetected while gross hematuria, which may occur only after the primary lesion has reached considerable size, may be improperly misattributed to other causes.

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Authors
  1. Robert G. Uzzo
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  2. Andrew C. Novick
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Editors and Affiliations

  1. Experimental Therapeutics, Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA

    Ronald M. Bukowski MD (Director) (Director)

  2. Department of Urology, Cleveland Clinic Foundation, Cleveland, OH, USA

    Andrew C. Novick MD (Chairman) (Chairman)

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Uzzo, R.G., Novick, A.C. (2000). The Role of Nephrectomy and Metastasectomy for Advanced Renal Cell Carcinoma. In: Bukowski, R.M., Novick, A.C. (eds) Renal Cell Carcinoma. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-229-6_14

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  • DOI: https://doi.org/10.1007/978-1-59259-229-6_14

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-6401-7

  • Online ISBN: 978-1-59259-229-6

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