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Zinc Deficiency

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Nutrition and Health in Developing Countries

Part of the book series: Nutrition ◊ and ◊ Health ((NH))

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Abstract

Zinc deficiency appears to be a common but overlooked problem in developing countries (1).The unique chemical properties of this transition element confer on zinc an important role in a wide variety of biological processes. Zinc occurs in the divalent state (Zn++) and does not exhibit redox chemistry in living organisms. It has a high affinity for electrons and typically binds to proteins, amino acids, peptides, and nucleotides, permitting both catalytic and structural functions. Intakes of zinc in populations are commonly lower than recommended levels, but adaption mechanisms preclude the development of severe deficiency states. There is increasing evidence, however, that adaption to low zinc intakes is not without consequence. Recent studies have shown that zinc supplementation reduces the morbidity and mortality from common childhood infectious diseases such as diarrhea, acute lower-respiratory infections, and malaria (2). A large and growing literature on zinc and immune function also emphasizes the importance of mild zinc deficiency in reducing resistance to infection (3).

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  1. Roger Shrimpton
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Editors and Affiliations

  1. Department of Ophthalmology, Division of Ocular Immunology, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Richard D. Semba MD, MPH

  2. Helen Keller International — Regional Headquarters, Jakarta, Indonesia

    Martin W. Bloem MD, PhD

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Shrimpton, R. (2001). Zinc Deficiency. In: Semba, R.D., Bloem, M.W. (eds) Nutrition and Health in Developing Countries. Nutrition ◊ and ◊ Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-225-8_12

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  • DOI: https://doi.org/10.1007/978-1-59259-225-8_12

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