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Type I Family Growth Factor Receptors and Their Ligands in Prostate Cancer

  • Chapter
Endocrine Oncology

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Cancer cells characteristically grow in an apparently unregulated manner, and it is reasonable to hypothesize that this is a consequence of some derangement in their natural growth regulatory systems. Many experiments have been carried out to test this hypothesis, and there is much evidence to support the concept. The family of receptors and ligands most manifestly implicated, and in some cases proven, to be involved in cell transformation is the type I family, which consists of four receptors, epidermal growth factor receptor (EGFR), c-erbB-2, c-erbB-3, and c-erbB-4 (also known as HER1–4). A plethora of ligands has been identified, currently totaling nine separate genes, but several of these are produced as very complex sets of splice variants. Indeed, c-erbB-4 has recently also been shown to be subject to splicing to produce four alternative full-length transcripts, and EGFR, c-erbB-2, and c-erbB-3 are all produced as alternatively spliced extra-cellular domain truncated proteins.

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Authors
  1. K. E. Leverton PhD
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  1. Department of Radiation Oncology, University of Michigan Cancer Center, Ann Arbor, MI, USA

    Stephen P. Ethier PhD

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Leverton, K.E., Gullick, W.J. (2000). Type I Family Growth Factor Receptors and Their Ligands in Prostate Cancer. In: Ethier, S.P. (eds) Endocrine Oncology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-223-4_14

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  • DOI: https://doi.org/10.1007/978-1-59259-223-4_14

  • Publisher Name: Humana Press, Totowa, NJ

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