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Fibroblast Growth Factors and Their Receptors in Breast and Prostate Cancer

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Endocrine Oncology

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

The fibroblast growth factor (FGF) family has emerged as perhaps the largest group of polypeptide growth factors to be involved in cellular growth and differentiation. It presently comprises more than 20 published members that share a varying degree of homology, and, with the exception of FGF7 and FGF10, which specifically act on epithelial cells (ECs), have a similar broad mitogenic spectrum, i.e., they promote the proliferation of a variety of cells, including those of mesodermal origin, and are angiogenic. With the exception of FGF8, their genes have similar organization and, in some cases, map to comparable regions on human and mouse chromosomes. Their pattern of expression is very different, ranging from restricted expression in some stages of development, e.g., FGF3, FGF4, and FGF5, to rather ubiquitous expression in a variety of tissues and organs, in the cases of FGF1 and FGF2. They all appear to bind heparin and heparan sulphate proteoglycans (HSPG) in the extracellular matrix, which originally led to their alternative grouping, as the heparin-binding growth factors (1).

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Authors
  1. R. C. Coombes MD, PhD
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  2. S. Marsh FRCS, MD
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  3. J. Gomm PhD
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  4. C. Johnston PhD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Michigan Cancer Center, Ann Arbor, MI, USA

    Stephen P. Ethier PhD

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© 2000 Humana Press Inc., Totowa, NJ

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Coombes, R.C., Marsh, S., Gomm, J., Johnston, C. (2000). Fibroblast Growth Factors and Their Receptors in Breast and Prostate Cancer. In: Ethier, S.P. (eds) Endocrine Oncology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-223-4_12

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  • DOI: https://doi.org/10.1007/978-1-59259-223-4_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9700-7

  • Online ISBN: 978-1-59259-223-4

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