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Regional Chemotherapy pp 87–99Cite as

Lung Perfusion for Treatment of Metastatic Sarcoma to the Lungs

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Part of the book series: Current Clinical Oncology ((CCO))

Abstract

The lung is among the most common sites involved in metastatic disease (1). Approximately 30% of patients with cancer will develop pulmonary metastases at some point in the course of their disease (2), and, more importantly, 20% of these patients will have metastatic disease limited to the lungs only (3). Soft tissue sarcomas (STSs) of an extremity metastasize almost exclusively to this organ (4). It is in this group of patients that pulmonary resection of metastases is most commonly performed, yielding 5-yr survival rates of 25–30% (5). However, a significant portion of these patients are unresectable, and systemic chemotherapy remains the only available option, which, in most patients, has not proven to be effective in prolonging survival or producing a durable response (6). This is may, in part, result from inadequate delivery of the drug to the lungs, when the chemotherapeutic agent is given by the intravenous (iv) route, because of dose-limiting toxicities. In an attempt to increase the therapeutic index of antineoplastic agents in this setting, lung perfusion was developed as an alternate method of delivering chemotherapy to minimize the drug’s systemic effects, and to allow larger doses to be delivered to the tumor.

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Authors
  1. David Liu
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  2. Michael Burt
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  3. Robert J. Ginsberg
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Editor information

Editors and Affiliations

  1. The Cleveland Clinic Taussig Cancer Center, Department of Hematology/Medical Oncology, The Cleveland Clinic Foundation, Cleveland, OH, USA

    Maurie Markman MD (Director, Chairman) (Director, Chairman)

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© 2000 Springer Science+Business Media New York

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Liu, D., Burt, M., Ginsberg, R.J. (2000). Lung Perfusion for Treatment of Metastatic Sarcoma to the Lungs. In: Markman, M. (eds) Regional Chemotherapy. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-219-7_6

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  • DOI: https://doi.org/10.1007/978-1-59259-219-7_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9697-0

  • Online ISBN: 978-1-59259-219-7

  • eBook Packages: Springer Book Archive

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