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Regional Chemotherapy pp 331–337Cite as

Regional Chemotherapy for Treatment and Prophylaxis of Meningeal Lymphoma

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Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Secondary central nervous system lymphoma (SCNSL) refers to lymphoma that initially involves the lymph nodes and, occasionally, extranodal sites, and only subsequently disseminates to the central nervous system (CNS). Many studies have reported the incidence of CNS involvement in patients with non-Hodgkin’ s lymphoma (1–6). Critical review of these early series is limited by the inclusion of all lymphoma histologies, the discrepancies between old and new lymphoma classifications, the lack of modern imaging modalities, the inclusion of patients with epidural involvement, and the inclusion of patients who received a variety of, and often substandard, chemotherapy regimens. In these large series of unselected patients with non-Hodgkin’s lymphoma, approx 5–11% of patients had CNS involvement. Incidence was very low in patients with follicular center, small lymphocytic, and other indolent lymphomas, but incidence was relatively high in patients with diffuse histology, (especially lymphoblastic and Burkitt’ s lymphoma), young age, poor performance status, more advanced-stage disease, and extranodal involvement (1–7).

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Authors
  1. Brad Pohlman
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Editors and Affiliations

  1. The Cleveland Clinic Taussig Cancer Center, Department of Hematology/Medical Oncology, The Cleveland Clinic Foundation, Cleveland, OH, USA

    Maurie Markman MD (Director, Chairman) (Director, Chairman)

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Pohlman, B. (2000). Regional Chemotherapy for Treatment and Prophylaxis of Meningeal Lymphoma. In: Markman, M. (eds) Regional Chemotherapy. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-219-7_21

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  • DOI: https://doi.org/10.1007/978-1-59259-219-7_21

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9697-0

  • Online ISBN: 978-1-59259-219-7

  • eBook Packages: Springer Book Archive

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