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Proximal Events in T-Cell Activation

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Signaling Networks and Cell Cycle Control

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Engagement of the T cell antigen receptor (TCR) triggers complex intracellular signaling cascades, leading to new gene expression, initiation of protein synthesis, induction of effector functions, and clonal expansion. Characterization of the details of TCR-mediated activation has been an intense and fruitful area of investigation in recent years. Such studies have demonstrated the central involvement of protein tyrosine kinases (PTKs) and phosphatases (PTPs) in T cell signaling. Rapid tyrosine phosphorylation mediated by the PTKs leads to multiple events, including molecular translocation to the TCR and PTKs, initiation of protein–protein interactions, enzyme activation, cytoskeletal changes, and translocation of signals to the nucleus. The focus of this review is on the early events of TCR engagement and activation, with particular emphasis on some of the most recent discoveries, adding further light to the sequential steps of T-cell signaling.

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Authors
  1. Joanne Sloan-Lancaster PhD
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  2. Lawrence E. Samelson MD
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Editors and Affiliations

  1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    J. Silvio Gutkind PhD

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© 2000 Humana Press Inc., Totowa, NJ

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Sloan-Lancaster, J., Samelson, L.E. (2000). Proximal Events in T-Cell Activation. In: Gutkind, J.S. (eds) Signaling Networks and Cell Cycle Control. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-218-0_6

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  • DOI: https://doi.org/10.1007/978-1-59259-218-0_6

  • Publisher Name: Humana Press, Totowa, NJ

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