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Integrin Signaling

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Signaling Networks and Cell Cycle Control

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Integrins fulfill a multitude of functions in embryonic cell migration and tissue organization, inflammation, wound repair, tumor cell invasion, and a variety of other biological and pathological processes. Over the past decade, it has become clear that integrins play central roles not only in adhesion and cell migration, but also in the regulation of growth, gene expression, and differentiation. Concepts of integrins have evolved from considering these receptors as simple cell surface binding moieties for extracellular adhesion molecules to the realization that they also serve complex roles as activators or modulators of signal transduction. As summarized in Fig. 1, integrins can stimulate a surprising range of signal transduction pathways. Integrin—ligand interactions trigger or modulate a variety of kinases, lipid signaling pathways, ion fluxes, and gene transcription events, as well as helping to organize the cytoskeleton. This broad repertoire of responses is consistent with the current view that integrins are central mediators of information transfer between cells and the extracellular matrix, and sometimes other cells, both at the physical/structural level and at the level of signal transduction. Research on integrin signaling has been expanding rapidly (a few of the many recent reviews in the area include refs. 1–9).

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Authors
  1. Kenneth M. Yamada MD, PhD
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  2. Erik H. J. Danen PhD
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Editors and Affiliations

  1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    J. Silvio Gutkind PhD

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© 2000 Humana Press Inc., Totowa, NJ

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Yamada, K.M., Danen, E.H.J. (2000). Integrin Signaling. In: Gutkind, J.S. (eds) Signaling Networks and Cell Cycle Control. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-218-0_1

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  • DOI: https://doi.org/10.1007/978-1-59259-218-0_1

  • Publisher Name: Humana Press, Totowa, NJ

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